FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051234108> ?p ?o ?g. }

• W2051234108 endingPage "e88976" @default.
• W2051234108 startingPage "e88976" @default.
• W2051234108 abstract "Hemozoin (Hz) is a heme crystal produced by some blood-feeding organisms, as an efficient way to detoxify heme derived from hemoglobin digestion. In the triatomine insect Rhodnius prolixus, Hz is essentially produced by midgut extracellular phospholipid membranes known as perimicrovillar membranes (PMVM). Here, we investigated the role of commercial glycerophospholipids containing serine, choline and ethanolamine as headgroups and R. prolixus midgut lipids (RML) in heme crystallization. All commercial unsaturated forms of phospholipids, as well as RML, mediated fast and efficient β-hematin formation by means of two kinetically distinct mechanisms: an early and fast component, followed by a late and slow one. The fastest reactions observed were induced by unsaturated forms of phosphatidylethanolamine (uPE) and phosphatidylcholine (uPC), with half-lives of 0.04 and 0.7 minutes, respectively. β-hematin crystal morphologies were strikingly distinct among groups, with uPE producing homogeneous regular brick-shaped crystals. Interestingly, uPC-mediated reactions resulted in two morphologically distinct crystal populations: one less representative group of regular crystals, resembling those induced by uPE, and the other largely represented by crystals with numerous sharp edges and tapered ends. Heme crystallization reactions induced by RML were efficient, with a heme to β-hematin conversion rate higher than 70%, but clearly slower (t1/2 of 9.9–17.7 minutes) than those induced by uPC and uPE. Interestingly, crystals produced by RML were homogeneous in shape and quite similar to those mediated by uPE. Thus, β-hematin formation can be rapidly and efficiently induced by unsaturated glycerophospholipids, particularly uPE and uPC, and may play a role on biological heme crystallization in R. prolixus midgut." @default.
• W2051234108 created "2016-06-24" @default.
• W2051234108 creator A5012580074 @default.
• W2051234108 creator A5025547944 @default.
• W2051234108 creator A5042702055 @default.
• W2051234108 creator A5051041482 @default.
• W2051234108 creator A5059857190 @default.
• W2051234108 creator A5062196069 @default.
• W2051234108 creator A5072304126 @default.
• W2051234108 date "2014-02-26" @default.
• W2051234108 modified "2023-10-18" @default.
• W2051234108 title "Unsaturated Glycerophospholipids Mediate Heme Crystallization: Biological Implications for Hemozoin Formation in the Kissing Bug Rhodnius prolixus" @default.
• W2051234108 cites W118220357 @default.
• W2051234108 cites W1491935126 @default.
• W2051234108 cites W1493715460 @default.
• W2051234108 cites W1504481059 @default.
• W2051234108 cites W1507058255 @default.
• W2051234108 cites W1529510611 @default.
• W2051234108 cites W1540660343 @default.
• W2051234108 cites W1595362376 @default.
• W2051234108 cites W1621479867 @default.
• W2051234108 cites W1655162787 @default.
• W2051234108 cites W1931919521 @default.
• W2051234108 cites W1967260711 @default.
• W2051234108 cites W1973470114 @default.
• W2051234108 cites W1976146170 @default.
• W2051234108 cites W1977399012 @default.
• W2051234108 cites W1979578847 @default.
• W2051234108 cites W1984954439 @default.
• W2051234108 cites W1993213550 @default.
• W2051234108 cites W1994787682 @default.
• W2051234108 cites W1998176459 @default.
• W2051234108 cites W1999937928 @default.
• W2051234108 cites W2002763668 @default.
• W2051234108 cites W2005898614 @default.
• W2051234108 cites W2005979909 @default.
• W2051234108 cites W2006250595 @default.
• W2051234108 cites W2018596911 @default.
• W2051234108 cites W2029761828 @default.
• W2051234108 cites W2033907571 @default.
• W2051234108 cites W2035062424 @default.
• W2051234108 cites W2035707213 @default.
• W2051234108 cites W2036181226 @default.
• W2051234108 cites W2038889556 @default.
• W2051234108 cites W2045439381 @default.
• W2051234108 cites W2048160714 @default.
• W2051234108 cites W2048704317 @default.
• W2051234108 cites W2048817002 @default.
• W2051234108 cites W2049493521 @default.
• W2051234108 cites W2051763876 @default.
• W2051234108 cites W2066569656 @default.
• W2051234108 cites W2088123956 @default.
• W2051234108 cites W2089663794 @default.
• W2051234108 cites W2091524167 @default.
• W2051234108 cites W2093770208 @default.
• W2051234108 cites W2099136192 @default.
• W2051234108 cites W2111815242 @default.
• W2051234108 cites W2111878207 @default.
• W2051234108 cites W2121356018 @default.
• W2051234108 cites W2145500686 @default.
• W2051234108 cites W2153217443 @default.
• W2051234108 cites W2158679181 @default.
• W2051234108 cites W2160278923 @default.
• W2051234108 cites W2168321291 @default.
• W2051234108 cites W2333058604 @default.
• W2051234108 cites W3082816727 @default.
• W2051234108 doi "https://doi.org/10.1371/journal.pone.0088976" @default.
• W2051234108 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3935856" @default.
• W2051234108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24586467" @default.
• W2051234108 hasPublicationYear "2014" @default.
• W2051234108 type Work @default.
• W2051234108 sameAs 2051234108 @default.
• W2051234108 citedByCount "11" @default.
• W2051234108 countsByYear W20512341082016 @default.
• W2051234108 countsByYear W20512341082018 @default.
• W2051234108 countsByYear W20512341082020 @default.
• W2051234108 countsByYear W20512341082021 @default.
• W2051234108 countsByYear W20512341082022 @default.
• W2051234108 countsByYear W20512341082023 @default.
• W2051234108 crossrefType "journal-article" @default.
• W2051234108 hasAuthorship W2051234108A5012580074 @default.
• W2051234108 hasAuthorship W2051234108A5025547944 @default.
• W2051234108 hasAuthorship W2051234108A5042702055 @default.
• W2051234108 hasAuthorship W2051234108A5051041482 @default.
• W2051234108 hasAuthorship W2051234108A5059857190 @default.
• W2051234108 hasAuthorship W2051234108A5062196069 @default.
• W2051234108 hasAuthorship W2051234108A5072304126 @default.
• W2051234108 hasBestOaLocation W20512341081 @default.
• W2051234108 hasConcept C12554922 @default.
• W2051234108 hasConcept C150149183 @default.
• W2051234108 hasConcept C173758957 @default.
• W2051234108 hasConcept C178790620 @default.
• W2051234108 hasConcept C181199279 @default.
• W2051234108 hasConcept C185592680 @default.
• W2051234108 hasConcept C18903297 @default.
• W2051234108 hasConcept C203036418 @default.
• W2051234108 hasConcept C2776028358 @default.
• W2051234108 hasConcept C2776110065 @default.

• next