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- W2051235979 abstract "Members of the PRDM protein family have been shown to play important roles during embryonic development. Previous in vitro and in situ analyses indicated a function of Prdm6 in cells of the vascular system. To reveal physiological functions of Prdm6, we generated conditional Prdm6-deficient mice. Complete deletion of Prdm6 results in embryonic lethality due to cardiovascular defects associated with aberrations in vascular patterning. However, smooth muscle cells could be regularly differentiated from Prdm6-deficient embryonic stem cells and vascular smooth muscle cells were present and proliferated normally in Prdm6-deficient embryos. Conditional deletion of Prdm6 in the smooth muscle cell lineage using a SM22-Cre driver line resulted in perinatal lethality due to hemorrhage in the lungs. We thus identified Prdm6 as a factor that is essential for the physiological control of cardiovascular development." @default.
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- W2051235979 date "2013-11-21" @default.
- W2051235979 modified "2023-10-17" @default.
- W2051235979 title "Prdm6 Is Essential for Cardiovascular Development In Vivo" @default.
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- W2051235979 doi "https://doi.org/10.1371/journal.pone.0081833" @default.
- W2051235979 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3836774" @default.
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- W2051235979 hasPublicationYear "2013" @default.
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