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• W2051236177 abstract "Objective: The objective of this work is to prepare oral dosage systems based on enteric materials in order to verify their possible use as Colon-Specific Drug Delivery Systems (CSDDSs).Methodology: In particular, three different copolymers of methyl-methacrylate (MMA) - acrylic acid (AA) are synthesized with increasing percentage of MMA (from 70% to 73%) and they are used to produce microparticles by the double-emulsion solvent evaporation method. The microparticles, loaded using theophylline as model drug, are then tested for drug release under varying pH to reproduce what happens in the human GI tract.Results: All the investigated systems have shown an effective pH sensitiveness: they show a good gastro-resistance, releasing the model drug only at higher pH, small intestine or colon, depending on the kind of used copolymer.Conclusion: The results confirm the usefulness of both the materials and the methods proposed in this study for colon-specific delivery applications." @default.
• W2051236177 created "2016-06-24" @default.
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• W2051236177 date "2012-10-15" @default.
• W2051236177 modified "2023-10-12" @default.
• W2051236177 title "<i>In vitro</i>dissolution of pH sensitive microparticles for colon-specific drug delivery" @default.
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• W2051236177 doi "https://doi.org/10.3109/10837450.2012.727005" @default.
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