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• W2051236244 abstract "Abstract Background Normal mammary gland contains an extravascular population of B lymphoblasts, precursors of the immunoglobulin plasma cells that play a key role in the passive protection of neonates by secreting immunoglobulins to colostrum and milk. We investigated the presence of chemoattractants in the milk by analysing the chemoattractant activity of various fractions of this secretion. Milk chemoattractants are potentially involved in the recruitment of lymphocytes from the maternal bloodstream in lactating mammary glands. Results The dilution-related lymphoid cell chemoattraction of whey was associated with a < 10 kDa ultrafiltrate. Active fractions were purified by reverse-phase high performance liquid chromatography. Two peptides of 2.7 kDa (DMREANYKNSDKYFHARGNYDAA) and 1 kDa (RPPGLPDKY) were identified as fragments of the SAA protein family, tentatively identified as SAA2. Only the 2.7 kDa synthetic peptide displayed chemotactic activity, at two different optimal concentrations. At the lower concentration (3.7 nM), it attracted B-cell lymphoblasts, whereas at the higher (3.7 μM), it attracted B lymphocytes. Then, the SAA mRNA expression was analysed and we observed more SAA transcripts during lactation than gestation. Conclusion These data are consistent with the SAA 23–45 fragment being involved in preplasma B-cell recruitment to the mammary gland and resultant benefit to the neonate." @default.
• W2051236244 created "2016-06-24" @default.
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• W2051236244 date "2009-01-23" @default.
• W2051236244 modified "2023-10-09" @default.
• W2051236244 title "Identification in milk of a serum amyloid A peptide chemoattractant for B lymphoblasts" @default.
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• W2051236244 doi "https://doi.org/10.1186/1471-2172-10-4" @default.
• W2051236244 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2637234" @default.
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