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- W2051236268 abstract "Activation of human monocytes or human monocytic cell lines by several types of stimuli coordinately induces IL-1β and its antagonist (IL-1Ra) gene expression; alterations in their balance seem to mediate the inflammatory response. Using the human monocytic cell line THP-1, we report that superantigens, such as staphylococcal enterotoxin A (SEA) and Mycoplasma arthritidis-derived superantigen (MAM) induce an increase in the level of IL-1β mRNA without any detectable effect on IL-1Ra mRNA. Unlike MAM-induced IL-1β mRNA, SEA-induced IL-1β mRNA was adequatly translated into protein. Superantigen-induced gene expression is mediated by signalling, via their receptors, the MHC class II molecules. Thus, it appears that this mode of signalling selectively induces the proinflammatory cytokine IL-1β gene expression which, by itself, can have major importance in disease pathology especially in autoimmune diseases." @default.
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- W2051236268 date "1994-06-01" @default.
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- W2051236268 title "Signaling via MHC Class II Molecules Selectively Induces IL-1β over IL-1 Receptor Antagonist Gene Expression" @default.
- W2051236268 doi "https://doi.org/10.1006/bbrc.1994.1779" @default.
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