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- W2051236614 abstract "Several flavonoids and isoflavonoids isolated from Balaton tart cherry were assayed for prostaglandin H endoperoxide synthase (PGHS-1) enzyme or cyclooxygenase isoform-1 (COX-1) activity. Genistein showed the highest COX-1 inhibitory activity among the isoflavonoids studied, with an IC50 value of 80 microM. Kaempferol gave the highest COX-1 inhibitory activity among the flavonoids tested, with an IC50 value of 180 microM. The structure-activity relationships of flavonoids and isoflavonoids revealed that hydroxyl groups at C4', C5 and C7 in isoflavonoids were essential for appreciable COX-1 inhibitory activity. Also, the C2-C3 double bond in flavonoids is important for COX-1 inhibitory activity. However, a hydroxyl group at the position decreased COX-1 inhibitory activity by flavonoids." @default.
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- W2051236614 date "2000-03-01" @default.
- W2051236614 modified "2023-09-27" @default.
- W2051236614 title "Cyclooxygenase active bioflavonoids from Balaton™ tart cherry and their structure activity relationships" @default.
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- W2051236614 doi "https://doi.org/10.1016/s0944-7113(00)80016-1" @default.
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