FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051237017> ?p ?o ?g. }

• W2051237017 endingPage "796" @default.
• W2051237017 startingPage "789" @default.
• W2051237017 abstract "PRSS16 is a serine protease expressed exclusively in cortical thymic epithelial cells (cTEC) of the thymus, suggesting that it plays a role in the processing of peptide antigens during the positive selection of T cells. Moreover, the human PRSS16 gene is encoded in a region near the class I major histocompatibility complex (MHC) that has been linked to type 1 diabetes mellitus susceptibility. The mouse orthologue Prss16 is conserved in genetic structure, sequence, and pattern of expression. To study the role of Prss16 in thymic development, we generated a deletion mutant of Prss16 and characterized T-lymphocyte populations and MHC class II expression on cortical thymic epithelial cells. Prss16-deficient mice develop normally, are fertile, and show normal thymic morphology, cellularity, and anatomy. The total numbers and frequencies of thymocytes and splenic T-cell populations did not differ from those of wild-type controls. Surface expression of MHC class II on cTEC was also similar in homozygous mutant and wild-type animals, and invariant chain degradation was not impaired by deletion of Prss16. These findings suggest that Prss16 is not required for quantitatively normal T-cell development." @default.
• W2051237017 created "2016-06-24" @default.
• W2051237017 creator A5005097038 @default.
• W2051237017 creator A5013188999 @default.
• W2051237017 creator A5029813521 @default.
• W2051237017 creator A5032263172 @default.
• W2051237017 creator A5044139519 @default.
• W2051237017 creator A5090529676 @default.
• W2051237017 date "2005-01-01" @default.
• W2051237017 modified "2023-10-16" @default.
• W2051237017 title "<i>Prss16</i> Is Not Required for T-Cell Development" @default.
• W2051237017 cites W1562198317 @default.
• W2051237017 cites W1605787182 @default.
• W2051237017 cites W1772624742 @default.
• W2051237017 cites W1983974380 @default.
• W2051237017 cites W1992196706 @default.
• W2051237017 cites W2001091352 @default.
• W2051237017 cites W2001513404 @default.
• W2051237017 cites W2007673642 @default.
• W2051237017 cites W2013436886 @default.
• W2051237017 cites W2014904488 @default.
• W2051237017 cites W2016120395 @default.
• W2051237017 cites W2024328494 @default.
• W2051237017 cites W2026129212 @default.
• W2051237017 cites W2026802569 @default.
• W2051237017 cites W2034385099 @default.
• W2051237017 cites W2055480930 @default.
• W2051237017 cites W2057999341 @default.
• W2051237017 cites W2066078821 @default.
• W2051237017 cites W2078566293 @default.
• W2051237017 cites W2080628580 @default.
• W2051237017 cites W2081492605 @default.
• W2051237017 cites W2089110736 @default.
• W2051237017 cites W2090354220 @default.
• W2051237017 cites W2097200313 @default.
• W2051237017 cites W2103173252 @default.
• W2051237017 cites W2122852190 @default.
• W2051237017 cites W2136552649 @default.
• W2051237017 cites W2139980032 @default.
• W2051237017 cites W2145221431 @default.
• W2051237017 cites W2164530670 @default.
• W2051237017 cites W2166876020 @default.
• W2051237017 cites W2167102170 @default.
• W2051237017 cites W2564152524 @default.
• W2051237017 cites W4232560691 @default.
• W2051237017 doi "https://doi.org/10.1128/mcb.25.2.789-796.2005" @default.
• W2051237017 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/543420" @default.
• W2051237017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15632078" @default.
• W2051237017 hasPublicationYear "2005" @default.
• W2051237017 type Work @default.
• W2051237017 sameAs 2051237017 @default.
• W2051237017 citedByCount "11" @default.
• W2051237017 countsByYear W20512370172012 @default.
• W2051237017 countsByYear W20512370172013 @default.
• W2051237017 countsByYear W20512370172018 @default.
• W2051237017 crossrefType "journal-article" @default.
• W2051237017 hasAuthorship W2051237017A5005097038 @default.
• W2051237017 hasAuthorship W2051237017A5013188999 @default.
• W2051237017 hasAuthorship W2051237017A5029813521 @default.
• W2051237017 hasAuthorship W2051237017A5032263172 @default.
• W2051237017 hasAuthorship W2051237017A5044139519 @default.
• W2051237017 hasAuthorship W2051237017A5090529676 @default.
• W2051237017 hasBestOaLocation W20512370172 @default.
• W2051237017 hasConcept C104317684 @default.
• W2051237017 hasConcept C143065580 @default.
• W2051237017 hasConcept C153911025 @default.
• W2051237017 hasConcept C170627219 @default.
• W2051237017 hasConcept C203014093 @default.
• W2051237017 hasConcept C207936829 @default.
• W2051237017 hasConcept C2776090121 @default.
• W2051237017 hasConcept C54355233 @default.
• W2051237017 hasConcept C86803240 @default.
• W2051237017 hasConcept C8891405 @default.
• W2051237017 hasConcept C95444343 @default.
• W2051237017 hasConceptScore W2051237017C104317684 @default.
• W2051237017 hasConceptScore W2051237017C143065580 @default.
• W2051237017 hasConceptScore W2051237017C153911025 @default.
• W2051237017 hasConceptScore W2051237017C170627219 @default.
• W2051237017 hasConceptScore W2051237017C203014093 @default.
• W2051237017 hasConceptScore W2051237017C207936829 @default.
• W2051237017 hasConceptScore W2051237017C2776090121 @default.
• W2051237017 hasConceptScore W2051237017C54355233 @default.
• W2051237017 hasConceptScore W2051237017C86803240 @default.
• W2051237017 hasConceptScore W2051237017C8891405 @default.
• W2051237017 hasConceptScore W2051237017C95444343 @default.
• W2051237017 hasIssue "2" @default.
• W2051237017 hasLocation W20512370171 @default.
• W2051237017 hasLocation W20512370172 @default.
• W2051237017 hasLocation W20512370173 @default.
• W2051237017 hasLocation W20512370174 @default.
• W2051237017 hasOpenAccess W2051237017 @default.
• W2051237017 hasPrimaryLocation W20512370171 @default.
• W2051237017 hasRelatedWork W1927860647 @default.
• W2051237017 hasRelatedWork W1983725845 @default.
• W2051237017 hasRelatedWork W2001548392 @default.
• W2051237017 hasRelatedWork W2009416280 @default.
• W2051237017 hasRelatedWork W2030437891 @default.
• W2051237017 hasRelatedWork W2045757315 @default.

• next