FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051237347> ?p ?o ?g. }

• W2051237347 endingPage "15" @default.
• W2051237347 startingPage "1" @default.
• W2051237347 abstract "Histone phosphorylation and chromatin structure were examined in synchronized CHO Chinese hamster cells during progression through mitosis. Cell population distribution in various phases of mitosis was determined by electron microscopy. Entry into mitosis was seen to occur in two stages: (1) the gathering of chromatin into aggregates of dense chromatin clumps during preprophase, followed by (2) the condensation of these aggregates into chromosome structures during prophase. Exit from mitosis was observed essentially as the reverse process, chromosomes first being disorganized into dense chromatin clumps during telophase, followed by dispersion of these aggregates in early G1. Correlating these structural changes with histone phosphorylation revealed that interphase-type histone H1 phosphorylation (H1I) involving 1–3 phosphates per molecule existed in interphase and during the chromatin aggregation stages of mitosis (preprophase and telophase). Also, no histone H3 phosphorylation occurred during these periods of the cell cycle. It is proposed that H1I phosphorylation may be involved with the submicroscopic changes in chromatin organization observed during interphase using molecular probes of chromatin structure. However, during mitosis, histone phosphorylation was correlated with microscopic chromatin structural changes. During the second stage of mitosis (prophase, metaphase, and anaphase), when chromosome structures were fully condensed, virtually all histone H1 existed as superphosphorylated molecules (H1M) containing 3–6 phosphates, and all histone H3 molecules were phosphorylated. Exit of cells from anaphase correlated closely with the dephosphorylation of H3 to unphosphorylated H3 and with the dephosphorylation of H1M to subphosphorylated H1 containing 0–3 phosphates. Further dephosphorylation of subphosphorylated H1I to unphosphorylated H1 occurred as these cells left telophase and entered G1. These experiments demonstrated that H1M superphosphorylation and H3 phosphorylation are strictly mitotic events which occur only when chromosomes are fully condensed. The absence of Colcemid in some of these experiments eliminates the possibility that H1M and H3 phosphorylations are artifacts of the Colcemid treatment. It is proposed that histones H1 and H3 may impose a restriction on chromatin structure which prevents chromosome condensation during interphase and that the H1M and H3 phosphorylations remove this restriction during mitosis." @default.
• W2051237347 created "2016-06-24" @default.
• W2051237347 creator A5060046174 @default.
• W2051237347 creator A5060627446 @default.
• W2051237347 creator A5078937757 @default.
• W2051237347 creator A5086712795 @default.
• W2051237347 creator A5091484920 @default.
• W2051237347 date "1978-03-01" @default.
• W2051237347 modified "2023-10-17" @default.
• W2051237347 title "Histone Phosphorylation and Chromatin Structure during Mitosis in Chinese Hamster Cells" @default.
• W2051237347 cites W1482723536 @default.
• W2051237347 cites W1540521703 @default.
• W2051237347 cites W1547908140 @default.
• W2051237347 cites W1555044868 @default.
• W2051237347 cites W1559378392 @default.
• W2051237347 cites W1570759257 @default.
• W2051237347 cites W1574385690 @default.
• W2051237347 cites W1963493061 @default.
• W2051237347 cites W1965219854 @default.
• W2051237347 cites W1966503216 @default.
• W2051237347 cites W1984339582 @default.
• W2051237347 cites W1985527733 @default.
• W2051237347 cites W1995527354 @default.
• W2051237347 cites W1996266432 @default.
• W2051237347 cites W1996555564 @default.
• W2051237347 cites W2002223314 @default.
• W2051237347 cites W2006431144 @default.
• W2051237347 cites W2013447794 @default.
• W2051237347 cites W2017077715 @default.
• W2051237347 cites W2018626566 @default.
• W2051237347 cites W2028895755 @default.
• W2051237347 cites W2028938083 @default.
• W2051237347 cites W2033299243 @default.
• W2051237347 cites W2033917594 @default.
• W2051237347 cites W2040044705 @default.
• W2051237347 cites W2047482758 @default.
• W2051237347 cites W2057850047 @default.
• W2051237347 cites W2059722081 @default.
• W2051237347 cites W2069469862 @default.
• W2051237347 cites W2090947724 @default.
• W2051237347 cites W2109401564 @default.
• W2051237347 cites W2115659567 @default.
• W2051237347 cites W2124754523 @default.
• W2051237347 cites W2131400267 @default.
• W2051237347 cites W2143224884 @default.
• W2051237347 cites W2176858216 @default.
• W2051237347 cites W2196306349 @default.
• W2051237347 cites W2316838174 @default.
• W2051237347 cites W2322149866 @default.
• W2051237347 cites W252178604 @default.
• W2051237347 cites W4235591502 @default.
• W2051237347 doi "https://doi.org/10.1111/j.1432-1033.1978.tb12135.x" @default.
• W2051237347 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/206429" @default.
• W2051237347 hasPublicationYear "1978" @default.
• W2051237347 type Work @default.
• W2051237347 sameAs 2051237347 @default.
• W2051237347 citedByCount "506" @default.
• W2051237347 countsByYear W20512373472012 @default.
• W2051237347 countsByYear W20512373472013 @default.
• W2051237347 countsByYear W20512373472014 @default.
• W2051237347 countsByYear W20512373472015 @default.
• W2051237347 countsByYear W20512373472016 @default.
• W2051237347 countsByYear W20512373472017 @default.
• W2051237347 countsByYear W20512373472018 @default.
• W2051237347 countsByYear W20512373472019 @default.
• W2051237347 countsByYear W20512373472020 @default.
• W2051237347 countsByYear W20512373472021 @default.
• W2051237347 countsByYear W20512373472022 @default.
• W2051237347 countsByYear W20512373472023 @default.
• W2051237347 crossrefType "journal-article" @default.
• W2051237347 hasAuthorship W2051237347A5060046174 @default.
• W2051237347 hasAuthorship W2051237347A5060627446 @default.
• W2051237347 hasAuthorship W2051237347A5078937757 @default.
• W2051237347 hasAuthorship W2051237347A5086712795 @default.
• W2051237347 hasAuthorship W2051237347A5091484920 @default.
• W2051237347 hasConcept C185592680 @default.
• W2051237347 hasConcept C2777755551 @default.
• W2051237347 hasConcept C54355233 @default.
• W2051237347 hasConcept C552990157 @default.
• W2051237347 hasConcept C56428682 @default.
• W2051237347 hasConcept C64927066 @default.
• W2051237347 hasConcept C83640560 @default.
• W2051237347 hasConcept C86803240 @default.
• W2051237347 hasConcept C93304396 @default.
• W2051237347 hasConcept C95444343 @default.
• W2051237347 hasConceptScore W2051237347C185592680 @default.
• W2051237347 hasConceptScore W2051237347C2777755551 @default.
• W2051237347 hasConceptScore W2051237347C54355233 @default.
• W2051237347 hasConceptScore W2051237347C552990157 @default.
• W2051237347 hasConceptScore W2051237347C56428682 @default.
• W2051237347 hasConceptScore W2051237347C64927066 @default.
• W2051237347 hasConceptScore W2051237347C83640560 @default.
• W2051237347 hasConceptScore W2051237347C86803240 @default.
• W2051237347 hasConceptScore W2051237347C93304396 @default.
• W2051237347 hasConceptScore W2051237347C95444343 @default.
• W2051237347 hasIssue "1" @default.
• W2051237347 hasLocation W20512373471 @default.
• W2051237347 hasLocation W20512373472 @default.

• next