FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051237456> ?p ?o ?g. }

• W2051237456 endingPage "406" @default.
• W2051237456 startingPage "402" @default.
• W2051237456 abstract "<b>Background:</b> We previously described hepatitis reactivation in two carriers of the hepatitis C virus (HCV) genotype 2c. <b>Aim:</b> To assess the relationship between HCV genotypes and risk of hepatitis reactivation, we studied the course of aminotransferases in patients infected with the two relevant genotypes in Italy. <b>Patients:</b> A cohort of 100 patients with genotype 2c chronic hepatitis and 106 with genotype 1b were subjected to surveillance. <b>Methods:</b> Hepatitis reactivation was defined as an alanine aminotransferase (ALT) value ⩾400 IU/l or a maximum/minimum ALT ratio value of ⩾8. <b>Results:</b> Over a period of 71 (24–144) months, one or more flares of ALT (201–2200 IU/l, 6–90 months’ duration) occurred in 31 patients with genotype 2c and in eight patients with genotype 1b (rates of flares: 55.6 per 1000 person years for genotype 2c <i>v</i> 15.0 for genotype 1b; p = 0.001). On repeat biopsy, hepatic fibrosis increased by more than 2 points in 10/16 patients examined either during or after an ALT flare compared with 7/36 flare free patients (63% <i>v</i> 19%; p = 0.003). Hepatitis flares were significantly associated with genotype 2c (odds ratio 6.48 (95% confidence interval 2.57–16.35)) but not with sex, age, modality or duration of infection, baseline ALT values or histological severity of hepatitis, hepatitis other than HCV, or reinfection. <b>Conclusions:</b> Genotype 2c carriers are at high risk of hepatitis reactivation, suggesting that virus genetic heterogeneity is important in the natural history of HCV, questioning the linearity of hepatic fibrosis progression during hepatitis C." @default.
• W2051237456 created "2016-06-24" @default.
• W2051237456 creator A5069656843 @default.
• W2051237456 date "2005-03-01" @default.
• W2051237456 modified "2023-10-17" @default.
• W2051237456 title "Hepatitis C reactivation in patients with chronic infection with genotypes 1b and 2c: a retrospective cohort study of 206 untreated patients" @default.
• W2051237456 cites W1479854981 @default.
• W2051237456 cites W1776783859 @default.
• W2051237456 cites W1980660411 @default.
• W2051237456 cites W1981900811 @default.
• W2051237456 cites W1985840221 @default.
• W2051237456 cites W1997368021 @default.
• W2051237456 cites W2001973858 @default.
• W2051237456 cites W2008662751 @default.
• W2051237456 cites W2013716066 @default.
• W2051237456 cites W2016441976 @default.
• W2051237456 cites W2021831138 @default.
• W2051237456 cites W2025615173 @default.
• W2051237456 cites W2031636658 @default.
• W2051237456 cites W2033992157 @default.
• W2051237456 cites W2047208492 @default.
• W2051237456 cites W2047568894 @default.
• W2051237456 cites W2058128629 @default.
• W2051237456 cites W2075293916 @default.
• W2051237456 cites W2076945923 @default.
• W2051237456 cites W2092181863 @default.
• W2051237456 cites W2097246425 @default.
• W2051237456 cites W2102693570 @default.
• W2051237456 cites W2102785869 @default.
• W2051237456 cites W2107826554 @default.
• W2051237456 cites W2119266617 @default.
• W2051237456 cites W2119612879 @default.
• W2051237456 cites W2132290252 @default.
• W2051237456 cites W2140123670 @default.
• W2051237456 cites W2149999920 @default.
• W2051237456 cites W2165558168 @default.
• W2051237456 cites W2168543151 @default.
• W2051237456 cites W2313300349 @default.
• W2051237456 cites W2315619302 @default.
• W2051237456 cites W2327525734 @default.
• W2051237456 cites W2333452860 @default.
• W2051237456 cites W2517346518 @default.
• W2051237456 cites W4229827290 @default.
• W2051237456 doi "https://doi.org/10.1136/gut.2004.048009" @default.
• W2051237456 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1774395" @default.
• W2051237456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15710990" @default.
• W2051237456 hasPublicationYear "2005" @default.
• W2051237456 type Work @default.
• W2051237456 sameAs 2051237456 @default.
• W2051237456 citedByCount "65" @default.
• W2051237456 countsByYear W20512374562012 @default.
• W2051237456 countsByYear W20512374562013 @default.
• W2051237456 countsByYear W20512374562014 @default.
• W2051237456 countsByYear W20512374562015 @default.
• W2051237456 countsByYear W20512374562016 @default.
• W2051237456 countsByYear W20512374562017 @default.
• W2051237456 countsByYear W20512374562019 @default.
• W2051237456 countsByYear W20512374562020 @default.
• W2051237456 countsByYear W20512374562021 @default.
• W2051237456 countsByYear W20512374562023 @default.
• W2051237456 crossrefType "journal-article" @default.
• W2051237456 hasAuthorship W2051237456A5069656843 @default.
• W2051237456 hasBestOaLocation W20512374561 @default.
• W2051237456 hasConcept C104317684 @default.
• W2051237456 hasConcept C126322002 @default.
• W2051237456 hasConcept C135763542 @default.
• W2051237456 hasConcept C156957248 @default.
• W2051237456 hasConcept C159047783 @default.
• W2051237456 hasConcept C203014093 @default.
• W2051237456 hasConcept C2522874641 @default.
• W2051237456 hasConcept C2775934546 @default.
• W2051237456 hasConcept C2776029263 @default.
• W2051237456 hasConcept C2776408679 @default.
• W2051237456 hasConcept C2776455275 @default.
• W2051237456 hasConcept C2777382497 @default.
• W2051237456 hasConcept C2777766500 @default.
• W2051237456 hasConcept C2778606649 @default.
• W2051237456 hasConcept C2780593183 @default.
• W2051237456 hasConcept C2781463415 @default.
• W2051237456 hasConcept C55493867 @default.
• W2051237456 hasConcept C71924100 @default.
• W2051237456 hasConcept C72563966 @default.
• W2051237456 hasConcept C86803240 @default.
• W2051237456 hasConcept C90924648 @default.
• W2051237456 hasConceptScore W2051237456C104317684 @default.
• W2051237456 hasConceptScore W2051237456C126322002 @default.
• W2051237456 hasConceptScore W2051237456C135763542 @default.
• W2051237456 hasConceptScore W2051237456C156957248 @default.
• W2051237456 hasConceptScore W2051237456C159047783 @default.
• W2051237456 hasConceptScore W2051237456C203014093 @default.
• W2051237456 hasConceptScore W2051237456C2522874641 @default.
• W2051237456 hasConceptScore W2051237456C2775934546 @default.
• W2051237456 hasConceptScore W2051237456C2776029263 @default.
• W2051237456 hasConceptScore W2051237456C2776408679 @default.
• W2051237456 hasConceptScore W2051237456C2776455275 @default.
• W2051237456 hasConceptScore W2051237456C2777382497 @default.
• W2051237456 hasConceptScore W2051237456C2777766500 @default.
• W2051237456 hasConceptScore W2051237456C2778606649 @default.

• next