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• W2051237860 abstract "No AccessJournal of UrologyInvestigative urology1 Feb 2006Partial Bladder Outlet Obstruction Induces Urethral Smooth Muscle Hypertrophy and Decreased Force Generation Joseph A. Hypolite, Shaohua Chang, Yongmu Zheng, Michael E. DiSanto, Stephen A. Zderic, Alan J. Wein, and Samuel Chacko Joseph A. HypoliteJoseph A. Hypolite More articles by this author , Shaohua ChangShaohua Chang More articles by this author , Yongmu ZhengYongmu Zheng More articles by this author , Michael E. DiSantoMichael E. DiSanto More articles by this author , Stephen A. ZdericStephen A. Zderic More articles by this author , Alan J. WeinAlan J. Wein More articles by this author , and Samuel ChackoSamuel Chacko More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)00138-2AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: PBOO leads to increased urinary frequency, decreased void volume, hypertrophy of the detrusor SM, and alterations in contractile and regulatory proteins. This study was done to determine whether PBOO induced increases in urinary frequency and detrusor SM hypertrophy are associated with an alteration in the contractility and expression of myosin isoforms in urethral SM. Materials and Methods: PBOO was surgically induced in male New Zealand White rabbits, and sham operated rabbits served as controls. After surgery, rabbits were kept 12 days, and prior to sacrifice, urine output and voiding frequency were monitored by keeping the animals in metabolic cages for 24 hours. Animals with increased urinary frequency (mean ± SEM 43 ± 12 voids per 24 hours) and sham operated rabbits (6 ± 3 voids per 24 hours) were used for this study. Morphology of the urethra was studied using light and immunofluorescence microscopy. The expression of myosin isoforms was analyzed at the mRNA and protein levels by RT-PCR and Western blotting. Results: The urethral wall and SM of PBOO rabbits showed hypertrophy. The force produced by the longitudinal muscle strips of PBOO animals in response to phenylephrine, KCl, or electrical field stimulation was decreased 50%, 37% and 40%, respectively. Immunofluorescence microscopy revealed a decrease in nerve density. RT-PCR and Western blotting showed a decrease in the expression of myosin isoform SM-B with a concomitant increase in SM-A at the mRNA and protein levels. Conclusions: Our data show hypertrophy of the urethral wall and SM, and alterations in contraction, innervation, and myosin isoforms in PBOO induced detrusor hypertrophy. References 1 : Neuroanatomical changes in the rat bladder after bladder outlet obstruction. Br J Urol1998; 82: 895. Crossref, Medline, Google Scholar 2 : Effect of bladder outlet obstruction on the morphology, physiology, and pharmacology of the bladder. Prostate Suppl1990; 3: 9. Google Scholar 3 : Urinary bladder of rat: fine structure of normal and hypertrophic musculature. Cell Tissue Res1990; 262: 67. Google Scholar 4 : Functional effects of in vitro obstruction on the rabbit urinary bladder. J Urol1986; 135: 847. Link, Google Scholar 5 : Hypertrophy changes the muscarinic receptor subtype mediating bladder contraction from M3 toward M2. Am J Physiol Regul Integr Comp Physiol2003; 285: R701. Google Scholar 6 : Voiding function: relevant anatomy, physiology, and pharmacology. In: Adult and Pediatric Urology. Edited by . Chicago: Year Book Medical Publishers1987: 800. chapt. 27. Google Scholar 7 : Voiding function: relevant anatomy, physiology, and pharmacology. In: Adult and Pediatric Urology. Edited by . Philadelphia: Mosby Year Book1991: 933. vol. 1, chapt. 28. Google Scholar 8 : Regional variation in myosin isoforms and phosphorylation at the resting tone in urinary bladder smooth muscle. Am J Physiol Cell Physiol2001; 280: C254. Google Scholar 9 : Alteration in expression of myosin isoforms in detrusor smooth muscle following bladder obstruction. Am J Physiol Cell Physiol2003; 285: C1397. Google Scholar 10 : Cholinergic, adrenergic and purinergic response of sequential strips of rabbit urinary bladder. J Pharmacol Exp Ther1980; 212: 536. Google Scholar 11 : NH2-terminal-inserted myosin II heavy chain is expressed in smooth muscle of small muscular arteries. Am J Physiol1997; 272: C1532. Google Scholar 12 : Estrogen modulates the expression of contractile proteins in the detrusor smooth muscle. J Urol1999; 161: 41. abstract 147. Google Scholar 13 : A new theory of micturition and urinary continence based on histomorphological studies. 4. The musculus dilator urethrae: force of micturition. Urol Int1994; 52: 189. Google Scholar 14 : Pathophysiology of outlet obstruction. In: The Bladder. Edited by . New York: Churchill Livingstone1995: 91. chapt. 5. Google Scholar 15 : The neuronal response to bladder outlet obstruction, a role for NGF. Adv Exp Med Biol1995; 385: 41. Google Scholar 16 : Decrease in the autonomic innervation of human detrusor muscle in outflow obstruction. J Urol1986; 136: 501. Link, Google Scholar 17 : An insert of seven amino acids confers functional differences between smooth muscle myosins from the intestines and vasculature. J Biol Chem1993; 268: 12848. Google Scholar 18 : Loss of SM-B myosin affects muscle shortening velocity and maximal force development. Nat Cell Biol2001; 3: 1025. Google Scholar Division of Urology and Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania© 2006 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 2February 2006Page: 777-782 Advertisement Copyright & Permissions© 2006 by American Urological AssociationKeywordsbladder neck obstructionrabbitsurethramusclebladdersmoothMetricsAuthor Information Joseph A. Hypolite More articles by this author Shaohua Chang More articles by this author Yongmu Zheng More articles by this author Michael E. DiSanto More articles by this author Stephen A. Zderic More articles by this author Alan J. Wein More articles by this author Samuel Chacko More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2051237860 title "Partial Bladder Outlet Obstruction Induces Urethral Smooth Muscle Hypertrophy and Decreased Force Generation" @default.
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