Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051238224> ?p ?o ?g. }
- W2051238224 endingPage "205" @default.
- W2051238224 startingPage "198" @default.
- W2051238224 abstract "Matrix metalloproteinases (MMPs) are proteolytic enzymes capable of degrading the structural support network for normal and malignant cells, promoting neoplastic cell invasion and metastasis. Tissue inhibitors of metalloproteinases (TIMPs) maintain connective tissue integrity by modulating MMP activity. Formalin-fixed paraffin-embedded tissue sections from 138 prostatic adenocarcinomas (PACs) were immunostained by a combined automated/manual method using monoclonal antibodies against MMP2 and TIMP2. Immunoreactivity was semiquantitatively scored based on stain intensity and distribution, and results were correlated with Gleason grade, pathologic stage, ploidy status, and disease recurrence. One hundred five of 138 (76%) and 113/138 (82%) PACs expressed MMP2 and TIMP2, respectively. Co-expression was observed in 94/138 (68%) of PACs (P =.01), correlated with advanced tumor stage (P =.05), and tended to be associated with disease recurrent cases (P =.07). TIMP2 expression individually correlated with advanced tumor stage (P =.04) and reached near significance with disease recurrence (P =.06). MMP2 expression was also more frequent in recurrent PACs, although this value did not reach statistical significance (P =.07). However, on multivariate analysis, only pathologic stage (P =.009) and ploidy status (P =.03) independently predicted disease recurrence. In conclusion, MMP2 and TIMP2 are co-expressed in a majority of PACs and correlate with prognostic variables. Interestingly, contrary to the previously documented anti-tumor effects of TIMPs, TIMP2 expression appears to have a tumor-promoting role in PACs and warrants further investigation." @default.
- W2051238224 created "2016-06-24" @default.
- W2051238224 creator A5002976957 @default.
- W2051238224 creator A5010153046 @default.
- W2051238224 creator A5032955549 @default.
- W2051238224 creator A5048976108 @default.
- W2051238224 creator A5084290551 @default.
- W2051238224 creator A5088559019 @default.
- W2051238224 date "2003-03-01" @default.
- W2051238224 modified "2023-10-01" @default.
- W2051238224 title "Prognostic Significance of Matrix Metalloproteinase 2 and Tissue Inhibitor of Metalloproteinase 2 Expression in Prostate Cancer" @default.
- W2051238224 cites W190590421 @default.
- W2051238224 cites W1966489616 @default.
- W2051238224 cites W1969688281 @default.
- W2051238224 cites W1972290870 @default.
- W2051238224 cites W1977208190 @default.
- W2051238224 cites W1978231657 @default.
- W2051238224 cites W19826679 @default.
- W2051238224 cites W1983609115 @default.
- W2051238224 cites W1988784463 @default.
- W2051238224 cites W2004849302 @default.
- W2051238224 cites W2010666975 @default.
- W2051238224 cites W2011120797 @default.
- W2051238224 cites W2020866554 @default.
- W2051238224 cites W2023897032 @default.
- W2051238224 cites W2025590649 @default.
- W2051238224 cites W2031006775 @default.
- W2051238224 cites W2034812193 @default.
- W2051238224 cites W2035548685 @default.
- W2051238224 cites W2040348117 @default.
- W2051238224 cites W2048013581 @default.
- W2051238224 cites W2050350916 @default.
- W2051238224 cites W2051347744 @default.
- W2051238224 cites W2059910197 @default.
- W2051238224 cites W2060719968 @default.
- W2051238224 cites W2060848035 @default.
- W2051238224 cites W2061707780 @default.
- W2051238224 cites W2063960633 @default.
- W2051238224 cites W2065493263 @default.
- W2051238224 cites W2067244053 @default.
- W2051238224 cites W2070004726 @default.
- W2051238224 cites W2072985853 @default.
- W2051238224 cites W2073246990 @default.
- W2051238224 cites W2075542566 @default.
- W2051238224 cites W2076718353 @default.
- W2051238224 cites W2080208733 @default.
- W2051238224 cites W2081918353 @default.
- W2051238224 cites W2083070422 @default.
- W2051238224 cites W2088172329 @default.
- W2051238224 cites W2088479573 @default.
- W2051238224 cites W2089223202 @default.
- W2051238224 cites W2091469332 @default.
- W2051238224 cites W2092834073 @default.
- W2051238224 cites W2122682237 @default.
- W2051238224 cites W2126666513 @default.
- W2051238224 cites W2188357563 @default.
- W2051238224 cites W2248001437 @default.
- W2051238224 cites W3026060259 @default.
- W2051238224 cites W4245042014 @default.
- W2051238224 cites W4250908540 @default.
- W2051238224 doi "https://doi.org/10.1097/01.mp.0000056984.62360.6c" @default.
- W2051238224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12640098" @default.
- W2051238224 hasPublicationYear "2003" @default.
- W2051238224 type Work @default.
- W2051238224 sameAs 2051238224 @default.
- W2051238224 citedByCount "82" @default.
- W2051238224 countsByYear W20512382242012 @default.
- W2051238224 countsByYear W20512382242013 @default.
- W2051238224 countsByYear W20512382242014 @default.
- W2051238224 countsByYear W20512382242015 @default.
- W2051238224 countsByYear W20512382242016 @default.
- W2051238224 countsByYear W20512382242017 @default.
- W2051238224 countsByYear W20512382242018 @default.
- W2051238224 countsByYear W20512382242019 @default.
- W2051238224 countsByYear W20512382242020 @default.
- W2051238224 countsByYear W20512382242021 @default.
- W2051238224 countsByYear W20512382242022 @default.
- W2051238224 crossrefType "journal-article" @default.
- W2051238224 hasAuthorship W2051238224A5002976957 @default.
- W2051238224 hasAuthorship W2051238224A5010153046 @default.
- W2051238224 hasAuthorship W2051238224A5032955549 @default.
- W2051238224 hasAuthorship W2051238224A5048976108 @default.
- W2051238224 hasAuthorship W2051238224A5084290551 @default.
- W2051238224 hasAuthorship W2051238224A5088559019 @default.
- W2051238224 hasBestOaLocation W20512382241 @default.
- W2051238224 hasConcept C109523444 @default.
- W2051238224 hasConcept C121608353 @default.
- W2051238224 hasConcept C126322002 @default.
- W2051238224 hasConcept C142724271 @default.
- W2051238224 hasConcept C146357865 @default.
- W2051238224 hasConcept C151730666 @default.
- W2051238224 hasConcept C204232928 @default.
- W2051238224 hasConcept C2775965246 @default.
- W2051238224 hasConcept C2779013556 @default.
- W2051238224 hasConcept C2780192828 @default.
- W2051238224 hasConcept C2780699576 @default.
- W2051238224 hasConcept C55728118 @default.
- W2051238224 hasConcept C63363279 @default.