FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051238467> ?p ?o ?g. }

• W2051238467 endingPage "212" @default.
• W2051238467 startingPage "207" @default.
• W2051238467 abstract "Saponins comprise a class of plant natural products that incorporate a lipophilic terpenoid core, to which is appended one or more carbohydrate residues. They are amphiphilic molecules and often exhibit toxic biological profiles, likely as a result of their roles as vital components in protective coatings to defend against phytopathogen infection and insect predation. The most notable of adjuvant-active saponins investigated for vaccine development come from the Chilean Soapbark Tree, Quillaja saponaria (i.e., QS). More than 30 years ago, semi-purified extracts (i.e., Quil A) from the cortex of Quillaja saponaria were found to be highly effective as adjuvants in veterinary vaccines. However, due to significant and variable toxicity effects, Quil A was not deemed appropriate for human vaccines. More refined purification methods have led to multiple fractions which are derived from the original plant extract. As such, QS-21 to date appears to be one of the more scientifically interesting and robust adjuvants in use in vaccinology. The role of QS-21 as an adjuvant for use in a variety of cancer vaccine trials and its comparison to other adjuvants is discussed in this review. Keywords: QS-21, adjuvant, vaccines, prostate cancer, immunogenicity, Cancer, Saponins, Prostate Specific Antigen, lipophilic terpenoid core, vaccinology" @default.
• W2051238467 created "2016-06-24" @default.
• W2051238467 creator A5039147214 @default.
• W2051238467 creator A5064147142 @default.
• W2051238467 date "2011-08-01" @default.
• W2051238467 modified "2023-10-14" @default.
• W2051238467 title "Enhancing Immunogenicity of Cancer Vaccines: QS-21 as an Immune Adjuvant" @default.
• W2051238467 cites W1561792475 @default.
• W2051238467 cites W1588713113 @default.
• W2051238467 cites W1610624614 @default.
• W2051238467 cites W1922307675 @default.
• W2051238467 cites W1971276124 @default.
• W2051238467 cites W1975040987 @default.
• W2051238467 cites W1975812348 @default.
• W2051238467 cites W1977690879 @default.
• W2051238467 cites W1983801561 @default.
• W2051238467 cites W1993632294 @default.
• W2051238467 cites W1994466260 @default.
• W2051238467 cites W2000659418 @default.
• W2051238467 cites W2003761800 @default.
• W2051238467 cites W2009034390 @default.
• W2051238467 cites W2009897979 @default.
• W2051238467 cites W2018208145 @default.
• W2051238467 cites W2018679102 @default.
• W2051238467 cites W2032947856 @default.
• W2051238467 cites W2046191057 @default.
• W2051238467 cites W2048175618 @default.
• W2051238467 cites W2054008872 @default.
• W2051238467 cites W2054681042 @default.
• W2051238467 cites W2085165735 @default.
• W2051238467 cites W2092161504 @default.
• W2051238467 cites W2103080556 @default.
• W2051238467 cites W2104696219 @default.
• W2051238467 cites W2112813954 @default.
• W2051238467 cites W2123501358 @default.
• W2051238467 cites W2128507275 @default.
• W2051238467 cites W2135172646 @default.
• W2051238467 cites W2135445993 @default.
• W2051238467 cites W2138607365 @default.
• W2051238467 cites W2319540709 @default.
• W2051238467 cites W2323813593 @default.
• W2051238467 cites W2411334039 @default.
• W2051238467 cites W2415797677 @default.
• W2051238467 cites W2473374310 @default.
• W2051238467 doi "https://doi.org/10.2174/157488511796391988" @default.
• W2051238467 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4248601" @default.
• W2051238467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25473385" @default.
• W2051238467 hasPublicationYear "2011" @default.
• W2051238467 type Work @default.
• W2051238467 sameAs 2051238467 @default.
• W2051238467 citedByCount "16" @default.
• W2051238467 countsByYear W20512384672013 @default.
• W2051238467 countsByYear W20512384672014 @default.
• W2051238467 countsByYear W20512384672015 @default.
• W2051238467 countsByYear W20512384672016 @default.
• W2051238467 countsByYear W20512384672018 @default.
• W2051238467 countsByYear W20512384672019 @default.
• W2051238467 countsByYear W20512384672020 @default.
• W2051238467 countsByYear W20512384672022 @default.
• W2051238467 countsByYear W20512384672023 @default.
• W2051238467 crossrefType "journal-article" @default.
• W2051238467 hasAuthorship W2051238467A5039147214 @default.
• W2051238467 hasAuthorship W2051238467A5064147142 @default.
• W2051238467 hasBestOaLocation W20512384672 @default.
• W2051238467 hasConcept C147483822 @default.
• W2051238467 hasConcept C203014093 @default.
• W2051238467 hasConcept C206103511 @default.
• W2051238467 hasConcept C2777863537 @default.
• W2051238467 hasConcept C2780868878 @default.
• W2051238467 hasConcept C3020289777 @default.
• W2051238467 hasConcept C55493867 @default.
• W2051238467 hasConcept C556039675 @default.
• W2051238467 hasConcept C71924100 @default.
• W2051238467 hasConcept C86803240 @default.
• W2051238467 hasConcept C8891405 @default.
• W2051238467 hasConcept C98274493 @default.
• W2051238467 hasConceptScore W2051238467C147483822 @default.
• W2051238467 hasConceptScore W2051238467C203014093 @default.
• W2051238467 hasConceptScore W2051238467C206103511 @default.
• W2051238467 hasConceptScore W2051238467C2777863537 @default.
• W2051238467 hasConceptScore W2051238467C2780868878 @default.
• W2051238467 hasConceptScore W2051238467C3020289777 @default.
• W2051238467 hasConceptScore W2051238467C55493867 @default.
• W2051238467 hasConceptScore W2051238467C556039675 @default.
• W2051238467 hasConceptScore W2051238467C71924100 @default.
• W2051238467 hasConceptScore W2051238467C86803240 @default.
• W2051238467 hasConceptScore W2051238467C8891405 @default.
• W2051238467 hasConceptScore W2051238467C98274493 @default.
• W2051238467 hasIssue "3" @default.
• W2051238467 hasLocation W20512384671 @default.
• W2051238467 hasLocation W20512384672 @default.
• W2051238467 hasLocation W20512384673 @default.
• W2051238467 hasLocation W20512384674 @default.
• W2051238467 hasOpenAccess W2051238467 @default.
• W2051238467 hasPrimaryLocation W20512384671 @default.
• W2051238467 hasRelatedWork W1481917790 @default.
• W2051238467 hasRelatedWork W1519040467 @default.
• W2051238467 hasRelatedWork W2062138252 @default.

• next