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- W2051238515 abstract "Polyethylenimines are cationic polymers with potential as delivery vectors in gene therapy and with proven antimicrobial activity. However, the antiviral activity of polyethylenimines has not been addressed in detail thus far. We have studied the inhibitory effects of a linear 25-kDa polyethylenimine on infections with human papillomaviruses and human cytomegaloviruses. Preincubation of cells with polyethylenimine blocked primary attachment of both viruses to cells, resulting in a significant reduction of infection. In addition, the dissemination of human cytomegalovirus in culture cells was efficiently reduced by recurrent administration of polyethylenimine. Polyethylenimine concentrations required for inhibition of human papillomavirus and cytomegalovirus did not cause any cytotoxic effects. Polyethylenimines and their derivatives may thus be attractive molecules for the development of antiviral microbicides." @default.
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- W2051238515 date "2012-01-01" @default.
- W2051238515 modified "2023-09-24" @default.
- W2051238515 title "Polyethylenimine Is a Strong Inhibitor of Human Papillomavirus and Cytomegalovirus Infection" @default.
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- W2051238515 doi "https://doi.org/10.1128/aac.05147-11" @default.
- W2051238515 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3256013" @default.
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