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- W2051238663 abstract "Persistent pulmonary hypertension of the newborn (PPHN), is a syndrome associated with high morbidity and mortality. Mechanical ventilation attempts to maintain a Paco2 < 30 torr and a pH > 7.5 until pulmonary hypertension resolves. To assess whether the disease or its therapy adversely affects neurodevelopmental or cardiorespiratory outcome, 11 infants diagnosed and treated for PPHN were evaluated at a mean age of 31 months. Nine had normal developmental quotients (DQs) and 2 had mildly delayed DQs. Eight children were entirely normal neurologically, 2 had slightly increased lower-extremity tone, and 1 had unilateral hypertonia. All cardiac exams, echocardiograms, and ECGs were normal. Four children had chronic lung disease requiring either daily or intermittent bronchodilator therapy; however, their activity levels were unaffected. These results suggest that subsequent normal development with little significant medical compromise may be expected in this group of critically ill infants." @default.
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- W2051238663 date "1984-07-01" @default.
- W2051238663 modified "2023-10-18" @default.
- W2051238663 title "Long-term follow-up of newborns with persistent pulmonary hypertension" @default.
- W2051238663 doi "https://doi.org/10.1097/00003246-198407000-00007" @default.
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