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- W2051238942 abstract "Summary: Genetic immunization is a novel method for vaccination in which DNA is delivered into the host to drive both cellular and humoral immune responses against its protein product. While genetic immunization can be potent, it requires that one have, in hand, a gene that encodes a protective protein antigen. Therefore, for many diseases, one cannot make a genetic vaccine because no protective antigen is known or no gene for this antigen is available. This lack of candidate antigens and their genes is a considerable bottleneck in developing new vaccines against old infectious agents, new emerging pathogens, and bioweapons. To address this limitation, we developed expression library immunization (ELI) as a high‐throughput technology to discover vaccine candidate genes at will, by using the immune system to screen the entire genome of a pathogen for vaccine candidate. To date, ELI has discovered new vaccine candidates from a diverse set of bacterial, fungal, and parasitic pathogens. In addition, the process of applying ELI to the genome of pathogens allows one to genetically re‐engineer these antigens to convert immunoevasive pathogen proteins into immunostimulatory vaccine antigens. Therefore, ELI is a potent technology to discover new vaccines and also generate genomic vaccines with amplified, multivalent immunostimulatory capacities." @default.
- W2051238942 created "2016-06-24" @default.
- W2051238942 creator A5008322901 @default.
- W2051238942 creator A5028707363 @default.
- W2051238942 creator A5032531656 @default.
- W2051238942 creator A5069789759 @default.
- W2051238942 creator A5073092010 @default.
- W2051238942 date "2004-05-05" @default.
- W2051238942 modified "2023-10-11" @default.
- W2051238942 title "Expression library immunization to discover and improve vaccine antigens" @default.
- W2051238942 cites W1485224098 @default.
- W2051238942 cites W1536760754 @default.
- W2051238942 cites W1570526167 @default.
- W2051238942 cites W1617728256 @default.
- W2051238942 cites W172906062 @default.
- W2051238942 cites W1782287000 @default.
- W2051238942 cites W1797827588 @default.
- W2051238942 cites W1839298807 @default.
- W2051238942 cites W1896024874 @default.
- W2051238942 cites W1914759134 @default.
- W2051238942 cites W1966023886 @default.
- W2051238942 cites W1966270205 @default.
- W2051238942 cites W1966876268 @default.
- W2051238942 cites W1967377083 @default.
- W2051238942 cites W1969918693 @default.
- W2051238942 cites W1970213967 @default.
- W2051238942 cites W1971027698 @default.
- W2051238942 cites W1972891435 @default.
- W2051238942 cites W1975867261 @default.
- W2051238942 cites W1976707492 @default.
- W2051238942 cites W1977344200 @default.
- W2051238942 cites W1981875981 @default.
- W2051238942 cites W1982762606 @default.
- W2051238942 cites W1986822828 @default.
- W2051238942 cites W1987467454 @default.
- W2051238942 cites W1988136894 @default.
- W2051238942 cites W1990004471 @default.
- W2051238942 cites W2000363784 @default.
- W2051238942 cites W2001144732 @default.
- W2051238942 cites W2002022916 @default.
- W2051238942 cites W2002551039 @default.
- W2051238942 cites W2009685908 @default.
- W2051238942 cites W2010281083 @default.
- W2051238942 cites W2013124695 @default.
- W2051238942 cites W2014254835 @default.
- W2051238942 cites W2014487476 @default.
- W2051238942 cites W2014495927 @default.
- W2051238942 cites W2020828649 @default.
- W2051238942 cites W2023358346 @default.
- W2051238942 cites W2027078741 @default.
- W2051238942 cites W2027724567 @default.
- W2051238942 cites W2028609919 @default.
- W2051238942 cites W2033054937 @default.
- W2051238942 cites W2044197227 @default.
- W2051238942 cites W2046776686 @default.
- W2051238942 cites W2049941865 @default.
- W2051238942 cites W2051549401 @default.
- W2051238942 cites W2052984389 @default.
- W2051238942 cites W2056333570 @default.
- W2051238942 cites W2056877436 @default.
- W2051238942 cites W2058326770 @default.
- W2051238942 cites W2062454840 @default.
- W2051238942 cites W2067721805 @default.
- W2051238942 cites W2068132079 @default.
- W2051238942 cites W2070426326 @default.
- W2051238942 cites W2071056869 @default.
- W2051238942 cites W2071492067 @default.
- W2051238942 cites W2071767025 @default.
- W2051238942 cites W2080515993 @default.
- W2051238942 cites W2085542638 @default.
- W2051238942 cites W2085613585 @default.
- W2051238942 cites W2085907970 @default.
- W2051238942 cites W2088908235 @default.
- W2051238942 cites W2089695010 @default.
- W2051238942 cites W2092438678 @default.
- W2051238942 cites W2094724411 @default.
- W2051238942 cites W2095843724 @default.
- W2051238942 cites W2096371952 @default.
- W2051238942 cites W2101581475 @default.
- W2051238942 cites W2104892940 @default.
- W2051238942 cites W2106337333 @default.
- W2051238942 cites W2109347706 @default.
- W2051238942 cites W2110292280 @default.
- W2051238942 cites W2112082168 @default.
- W2051238942 cites W2117929568 @default.
- W2051238942 cites W2119102760 @default.
- W2051238942 cites W2122847734 @default.
- W2051238942 cites W2124607980 @default.
- W2051238942 cites W2131974188 @default.
- W2051238942 cites W2134229975 @default.
- W2051238942 cites W2135169564 @default.
- W2051238942 cites W2140493934 @default.
- W2051238942 cites W2147851449 @default.
- W2051238942 cites W2152546316 @default.
- W2051238942 cites W2158248629 @default.
- W2051238942 cites W2161072107 @default.
- W2051238942 cites W2166336427 @default.
- W2051238942 cites W2178523848 @default.