FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051239639> ?p ?o ?g. }

• W2051239639 endingPage "e85401" @default.
• W2051239639 startingPage "e85401" @default.
• W2051239639 abstract "Schistosomiasis is caused by several worm species of the genus Schistosoma and afflicts up to 600 million people in 74 tropical and sub-tropical countries in the developing world. Present disease control depends on treatment with the only available drug praziquantel. No vaccine exists despite the intense search for molecular candidates and adjuvant formulations over the last three decades. Cysteine peptidases such as papain and Der p 1 are well known environmental allergens that sensitize the immune system driving potent Th2-responses. Recently, we showed that the administration of active papain to mice induced significant protection (P<0.02, 50%) against an experimental challenge infection with Schistosoma mansoni. Since schistosomes express and secrete papain-like cysteine peptidases we reasoned that these could be employed as vaccines with inbuilt adjuvanticity to protect against these parasites. Here we demonstrate that sub-cutaneous injection of functionally active S. mansoni cathepsin B1 (SmCB1), or a cathepsin L from a related parasite Fasciola hepatica (FhCL1), elicits highly significant (P<0.0001) protection (up to 73%) against an experimental challenge worm infection. Protection and reduction in worm egg burden were further increased (up to 83%) when the cysteine peptidases were combined with other S. mansoni vaccine candidates, glyceraldehyde 3-phosphate dehydrogenase (SG3PDH) and peroxiredoxin (PRX-MAP), without the need to add chemical adjuvants. These studies demonstrate the capacity of helminth cysteine peptidases to behave simultaneously as immunogens and adjuvants, and offer an innovative approach towards developing schistosomiasis vaccines." @default.
• W2051239639 created "2016-06-24" @default.
• W2051239639 creator A5007399225 @default.
• W2051239639 creator A5017222582 @default.
• W2051239639 creator A5040944698 @default.
• W2051239639 creator A5048119828 @default.
• W2051239639 creator A5065088515 @default.
• W2051239639 creator A5068306483 @default.
• W2051239639 creator A5068367604 @default.
• W2051239639 date "2014-01-21" @default.
• W2051239639 modified "2023-09-24" @default.
• W2051239639 title "Cysteine Peptidases as Schistosomiasis Vaccines with Inbuilt Adjuvanticity" @default.
• W2051239639 cites W114138574 @default.
• W2051239639 cites W1685974124 @default.
• W2051239639 cites W1965366343 @default.
• W2051239639 cites W1965430190 @default.
• W2051239639 cites W1973272261 @default.
• W2051239639 cites W1973484636 @default.
• W2051239639 cites W1976811600 @default.
• W2051239639 cites W1978378727 @default.
• W2051239639 cites W1982187630 @default.
• W2051239639 cites W1983687616 @default.
• W2051239639 cites W1991327975 @default.
• W2051239639 cites W1994660543 @default.
• W2051239639 cites W2002185329 @default.
• W2051239639 cites W2015928161 @default.
• W2051239639 cites W2019815618 @default.
• W2051239639 cites W2024802321 @default.
• W2051239639 cites W2025268916 @default.
• W2051239639 cites W2028504434 @default.
• W2051239639 cites W2033294362 @default.
• W2051239639 cites W2034013002 @default.
• W2051239639 cites W2037267600 @default.
• W2051239639 cites W2037328598 @default.
• W2051239639 cites W2047142949 @default.
• W2051239639 cites W2049656155 @default.
• W2051239639 cites W2053826122 @default.
• W2051239639 cites W2065705117 @default.
• W2051239639 cites W2071094213 @default.
• W2051239639 cites W2073747182 @default.
• W2051239639 cites W2078682911 @default.
• W2051239639 cites W2078909963 @default.
• W2051239639 cites W2080160266 @default.
• W2051239639 cites W2084153471 @default.
• W2051239639 cites W2084172998 @default.
• W2051239639 cites W2094169801 @default.
• W2051239639 cites W2097311057 @default.
• W2051239639 cites W2097950056 @default.
• W2051239639 cites W2105072635 @default.
• W2051239639 cites W2106262480 @default.
• W2051239639 cites W2109843249 @default.
• W2051239639 cites W2112548910 @default.
• W2051239639 cites W2112748508 @default.
• W2051239639 cites W2130020291 @default.
• W2051239639 cites W2135996116 @default.
• W2051239639 cites W2147746949 @default.
• W2051239639 cites W2148138050 @default.
• W2051239639 cites W2150840749 @default.
• W2051239639 cites W2151468816 @default.
• W2051239639 cites W2152512778 @default.
• W2051239639 cites W2154968994 @default.
• W2051239639 cites W2161045611 @default.
• W2051239639 cites W2171777269 @default.
• W2051239639 cites W2175847273 @default.
• W2051239639 cites W2176753778 @default.
• W2051239639 cites W2395113217 @default.
• W2051239639 cites W2402266690 @default.
• W2051239639 cites W2411848965 @default.
• W2051239639 cites W4229910463 @default.
• W2051239639 cites W84692877 @default.
• W2051239639 doi "https://doi.org/10.1371/journal.pone.0085401" @default.
• W2051239639 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3897446" @default.
• W2051239639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24465551" @default.
• W2051239639 hasPublicationYear "2014" @default.
• W2051239639 type Work @default.
• W2051239639 sameAs 2051239639 @default.
• W2051239639 citedByCount "51" @default.
• W2051239639 countsByYear W20512396392014 @default.
• W2051239639 countsByYear W20512396392015 @default.
• W2051239639 countsByYear W20512396392016 @default.
• W2051239639 countsByYear W20512396392017 @default.
• W2051239639 countsByYear W20512396392018 @default.
• W2051239639 countsByYear W20512396392019 @default.
• W2051239639 countsByYear W20512396392020 @default.
• W2051239639 countsByYear W20512396392021 @default.
• W2051239639 countsByYear W20512396392022 @default.
• W2051239639 countsByYear W20512396392023 @default.
• W2051239639 crossrefType "journal-article" @default.
• W2051239639 hasAuthorship W2051239639A5007399225 @default.
• W2051239639 hasAuthorship W2051239639A5017222582 @default.
• W2051239639 hasAuthorship W2051239639A5040944698 @default.
• W2051239639 hasAuthorship W2051239639A5048119828 @default.
• W2051239639 hasAuthorship W2051239639A5065088515 @default.
• W2051239639 hasAuthorship W2051239639A5068306483 @default.
• W2051239639 hasAuthorship W2051239639A5068367604 @default.
• W2051239639 hasBestOaLocation W20512396391 @default.
• W2051239639 hasConcept C142724271 @default.
• W2051239639 hasConcept C165901193 @default.

• next