FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051240572> ?p ?o ?g. }

• W2051240572 endingPage "185" @default.
• W2051240572 startingPage "184" @default.
• W2051240572 abstract "A 48-year-old man presented with severe pain in the scrotum and right gluteal area. Three days earlier he had noted a small perianal abscess. The patient was a bike rider, smoker, and hypertensive with no alcohol consumption or diabetes and could recall no local trauma. On admission he was febrile (38 °C), tachycardic (115 bpm), and hypotensive (98/66 mmHg). Examination of the genitalia revealed swelling, redness, pain on palpating the right gluteal and perianal areas, crepitations (subcutaneous gas), a foul smell, and dark fluid droplets on the scrotal skin. Laboratory results showed a white blood cell count of 18,740 cells/mL (88% neutrophils); his coagulation, liver and kidney functions were normal. Physical examination and chest X-rays were normal. He was immediately treated with intravenous penicillin, clindamycin, and ofloxacin. A total scrotectomy, with wide resection of the necrotic fascias, tissues, and skin of the right gluteal and inguinal region was performed. The patient deteriorated abruptly developing septic shock; the necrotic and infectious process rapidly advanced through the retroperitoneal space. Despite intensive supportive care and repeated extensive surgical debridement, the patient died 36 h after admission. The resected tissue cultures showed aerobic and anaerobic bacteria. Blood and urine cultures were negative. Pathology showed necrotic skin, subcutaneous tissues, and abscess formation. Blood vessels within the specimen were partially obstructed by fibrin and thrombi. A positive HIV-test result (ELISA) and Western Blot was received after the patient died. Fournier's gangrene (FG) is a necrotizing fasciitis of the genitalia and scrotal region due to a mixed aerobic–anaerobic infection and was first described in 1883.1Roca B. Cunat E. Simon E. HIV infection presenting with Fournier's gangrene.Neth J Med. 1998; 53: 168-171Crossref PubMed Scopus (14) Google Scholar Predisposing illnesses are diabetes (60%), hypertension (55%), obesity, smoking, alcoholism, renal failure, and immunosuppression.2Ayumba B.R. Magoha G.A. Epidemiological aspects of Fournier's gangrene at Kenyatta National Hospital.Nairobi. East Afr Med J. 1998; 75: 586-589PubMed Google Scholar, 3Yeniyol C.O. Suelozgen T. Arslan M. Ayder A.R. Fournier's gangrene: experience with 25 patients and use of Fournier's gangrene severity index score.Urology. 2004; 64: 218-222Abstract Full Text Full Text PDF PubMed Scopus (141) Google Scholar It has rarely been associated with HIV infection,1Roca B. Cunat E. Simon E. HIV infection presenting with Fournier's gangrene.Neth J Med. 1998; 53: 168-171Crossref PubMed Scopus (14) Google Scholar yet the relationship between them is questionable. Ayumba and Magoha2Ayumba B.R. Magoha G.A. Epidemiological aspects of Fournier's gangrene at Kenyatta National Hospital.Nairobi. East Afr Med J. 1998; 75: 586-589PubMed Google Scholar reported HIV as a comorbidity in 4% of FG patients. In addition, Elem and Ranjan4Elem B. Ranjan P. Impact of immunodeficiency virus (HIV) on Fournier's gangrene: observations in Zambia.Ann R Coll Surg Engl. 1995; 77: 283-286PubMed Google Scholar assumed that the presence of HIV infection does not affect the progression of FG. Our patient was a smoker and hypertensive; his HIV status was unknown on admission CD4 and viral-load were not measured. Most patients present later than 48 h after the onset of symptoms2Ayumba B.R. Magoha G.A. Epidemiological aspects of Fournier's gangrene at Kenyatta National Hospital.Nairobi. East Afr Med J. 1998; 75: 586-589PubMed Google Scholar with a fulminant progression causing multi-organ failure and death.1Roca B. Cunat E. Simon E. HIV infection presenting with Fournier's gangrene.Neth J Med. 1998; 53: 168-171Crossref PubMed Scopus (14) Google Scholar, 3Yeniyol C.O. Suelozgen T. Arslan M. Ayder A.R. Fournier's gangrene: experience with 25 patients and use of Fournier's gangrene severity index score.Urology. 2004; 64: 218-222Abstract Full Text Full Text PDF PubMed Scopus (141) Google Scholar Histologic examination of FG suggests an ischemic necrosis, obliterative endarteritis, and thrombosis of pudendal arteries. Hemodynamic stabilization, empiric broad-spectrum antimicrobial therapy, and urgent aggressive surgical debridement remain the hallmarks of treatment.1 Hyperbaric oxygen therapy may decrease the extent of tissue destruction as an adjunctive therapy but could not be a substitute for surgery or antimicrobial therapy.1Roca B. Cunat E. Simon E. HIV infection presenting with Fournier's gangrene.Neth J Med. 1998; 53: 168-171Crossref PubMed Scopus (14) Google Scholar, 3Yeniyol C.O. Suelozgen T. Arslan M. Ayder A.R. Fournier's gangrene: experience with 25 patients and use of Fournier's gangrene severity index score.Urology. 2004; 64: 218-222Abstract Full Text Full Text PDF PubMed Scopus (141) Google Scholar Our hospital does not have this technology, and a transfer was impossible since patient was hemodyanamically unstable and in need of urgent repeated surgeries. A patient's metabolic status, the extent of the disease at presentation, and the need for cystostomy/colostomy are important factors in the prognosis of FG;3Yeniyol C.O. Suelozgen T. Arslan M. Ayder A.R. Fournier's gangrene: experience with 25 patients and use of Fournier's gangrene severity index score.Urology. 2004; 64: 218-222Abstract Full Text Full Text PDF PubMed Scopus (141) Google Scholar global mortality is still high (20–30%).1Roca B. Cunat E. Simon E. HIV infection presenting with Fournier's gangrene.Neth J Med. 1998; 53: 168-171Crossref PubMed Scopus (14) Google Scholar, 2Ayumba B.R. Magoha G.A. Epidemiological aspects of Fournier's gangrene at Kenyatta National Hospital.Nairobi. East Afr Med J. 1998; 75: 586-589PubMed Google Scholar, 3Yeniyol C.O. Suelozgen T. Arslan M. Ayder A.R. Fournier's gangrene: experience with 25 patients and use of Fournier's gangrene severity index score.Urology. 2004; 64: 218-222Abstract Full Text Full Text PDF PubMed Scopus (141) Google Scholar Perineal arterial compression has been demonstrated in long distance cyclists;5Sommer F. Konig D. Graft C. Schwarzer U. Bertram C. Klotz T. et al.Impotence and genital numbness in cyclists.Int J Sports Med. 2001; 22: 410-413Crossref PubMed Scopus (80) Google Scholar our patient was a frequent bike rider. However, the relationship between bike riding and FG has not been established as a risk factor, so far. We speculate that repeated trauma to the perineum with an HIV-positive immunocompromised status could have been factors provoking a local trauma that led to a fatal infection. Conflict of interest: No conflict of interest to declare." @default.
• W2051240572 created "2016-06-24" @default.
• W2051240572 creator A5010142431 @default.
• W2051240572 creator A5015798539 @default.
• W2051240572 creator A5038785232 @default.
• W2051240572 creator A5044057338 @default.
• W2051240572 creator A5057673739 @default.
• W2051240572 creator A5075691382 @default.
• W2051240572 creator A5090268823 @default.
• W2051240572 date "2007-03-01" @default.
• W2051240572 modified "2023-10-13" @default.
• W2051240572 title "Fournier's gangrene as the initial presentation of HIV infection" @default.
• W2051240572 cites W2009789968 @default.
• W2051240572 cites W2084317043 @default.
• W2051240572 cites W2170572627 @default.
• W2051240572 doi "https://doi.org/10.1016/j.ijid.2006.02.007" @default.
• W2051240572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16931089" @default.
• W2051240572 hasPublicationYear "2007" @default.
• W2051240572 type Work @default.
• W2051240572 sameAs 2051240572 @default.
• W2051240572 citedByCount "5" @default.
• W2051240572 countsByYear W20512405722015 @default.
• W2051240572 countsByYear W20512405722016 @default.
• W2051240572 countsByYear W20512405722018 @default.
• W2051240572 countsByYear W20512405722021 @default.
• W2051240572 crossrefType "journal-article" @default.
• W2051240572 hasAuthorship W2051240572A5010142431 @default.
• W2051240572 hasAuthorship W2051240572A5015798539 @default.
• W2051240572 hasAuthorship W2051240572A5038785232 @default.
• W2051240572 hasAuthorship W2051240572A5044057338 @default.
• W2051240572 hasAuthorship W2051240572A5057673739 @default.
• W2051240572 hasAuthorship W2051240572A5075691382 @default.
• W2051240572 hasAuthorship W2051240572A5090268823 @default.
• W2051240572 hasBestOaLocation W20512405721 @default.
• W2051240572 hasConcept C141071460 @default.
• W2051240572 hasConcept C2776282561 @default.
• W2051240572 hasConcept C2776626339 @default.
• W2051240572 hasConcept C2777035434 @default.
• W2051240572 hasConcept C2777217379 @default.
• W2051240572 hasConcept C2777628635 @default.
• W2051240572 hasConcept C2778384902 @default.
• W2051240572 hasConcept C2779491700 @default.
• W2051240572 hasConcept C2780344330 @default.
• W2051240572 hasConcept C2911079008 @default.
• W2051240572 hasConcept C527108885 @default.
• W2051240572 hasConcept C71924100 @default.
• W2051240572 hasConceptScore W2051240572C141071460 @default.
• W2051240572 hasConceptScore W2051240572C2776282561 @default.
• W2051240572 hasConceptScore W2051240572C2776626339 @default.
• W2051240572 hasConceptScore W2051240572C2777035434 @default.
• W2051240572 hasConceptScore W2051240572C2777217379 @default.
• W2051240572 hasConceptScore W2051240572C2777628635 @default.
• W2051240572 hasConceptScore W2051240572C2778384902 @default.
• W2051240572 hasConceptScore W2051240572C2779491700 @default.
• W2051240572 hasConceptScore W2051240572C2780344330 @default.
• W2051240572 hasConceptScore W2051240572C2911079008 @default.
• W2051240572 hasConceptScore W2051240572C527108885 @default.
• W2051240572 hasConceptScore W2051240572C71924100 @default.
• W2051240572 hasIssue "2" @default.
• W2051240572 hasLocation W20512405721 @default.
• W2051240572 hasLocation W20512405722 @default.
• W2051240572 hasOpenAccess W2051240572 @default.
• W2051240572 hasPrimaryLocation W20512405721 @default.
• W2051240572 hasRelatedWork W2030770787 @default.
• W2051240572 hasRelatedWork W2033436209 @default.
• W2051240572 hasRelatedWork W2084980097 @default.
• W2051240572 hasRelatedWork W2086405135 @default.
• W2051240572 hasRelatedWork W2347685043 @default.
• W2051240572 hasRelatedWork W2404108288 @default.
• W2051240572 hasRelatedWork W2411483250 @default.
• W2051240572 hasRelatedWork W2495443309 @default.
• W2051240572 hasRelatedWork W2509356343 @default.
• W2051240572 hasRelatedWork W3144103120 @default.
• W2051240572 hasVolume "11" @default.
• W2051240572 isParatext "false" @default.
• W2051240572 isRetracted "false" @default.
• W2051240572 magId "2051240572" @default.
• W2051240572 workType "article" @default.