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- W2051240944 abstract "The relationship between Ca(2+) influx through voltage-activated Ca(2+) channels, resting intracellular Ca(2+) level (Ca(i)) and Ca(2+)-dependent exocytosis was studied in bovine adrenal chromaffin cells by using patch-clamp, capacitance, and fluorescent measurements. It was established that depolarization-induced exocytosis passed over two steps, both of which linearly depend on Ca(i). At Ca(i) lying below critical point (200-300 nM) the slope of the relationship was 4.43 and at Ca(i) exceeding the critical point the slope was equal to 31.63. The vesicular mechanism describing experimental two-step dependence of exocytosis on intracellular Ca(2+) (Ca(i)) is proposed. According to the model at Ca(i) below critical point only small-sized vesicles fuse with plasma membrane, whereas at higher Ca(i), larger vesicles started to fuse." @default.
- W2051240944 created "2016-06-24" @default.
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- W2051240944 date "2001-11-01" @default.
- W2051240944 modified "2023-09-23" @default.
- W2051240944 title "Different Secretory Vesicles Can Be Involved in Depolarization-Evoked Exocytosis" @default.
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- W2051240944 doi "https://doi.org/10.1006/bbrc.2001.5844" @default.
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