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• W2051242197 abstract "Synonymous mutations do not alter the encoded protein, but they can influence gene expression. To investigate how, we engineered a synthetic library of 154 genes that varied randomly at synonymous sites, but all encoded the same green fluorescent protein (GFP). When expressed in Escherichia coli, GFP protein levels varied 250-fold across the library. GFP messenger RNA (mRNA) levels, mRNA degradation patterns, and bacterial growth rates also varied, but codon bias did not correlate with gene expression. Rather, the stability of mRNA folding near the ribosomal binding site explained more than half the variation in protein levels. In our analysis, mRNA folding and associated rates of translation initiation play a predominant role in shaping expression levels of individual genes, whereas codon bias influences global translation efficiency and cellular fitness." @default.
• W2051242197 created "2016-06-24" @default.
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• W2051242197 date "2009-04-10" @default.
• W2051242197 modified "2023-10-10" @default.
• W2051242197 title "Coding-Sequence Determinants of Gene Expression in <i>Escherichia coli</i>" @default.
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• W2051242197 doi "https://doi.org/10.1126/science.1170160" @default.
• W2051242197 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3902468" @default.
• W2051242197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19359587" @default.
• W2051242197 hasPublicationYear "2009" @default.
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