Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051243140> ?p ?o ?g. }
- W2051243140 endingPage "9" @default.
- W2051243140 startingPage "1" @default.
- W2051243140 abstract "Peroxisome proliferator-activated receptors (PPARs) have lately attracted much attention as therapeutic targets. Previously, PPAR ligands were associated with the treatment of diabetes, hyperlipidemia and cardiovascular diseases, as they modulate the expression of genes regulating glucose and lipid metabolism. Recently, PPAR ligands have been also considered as potential anticancer agents, with relatively low systemic toxicity. The emerging evidence for antiproliferative, proapoptotic, antiinflammatory and potential antimetastatic properties of PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>α</mml:mi></mml:math>ligands prompted us to discuss possible roles of PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>α</mml:mi></mml:math>in tumor suppression. PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>α</mml:mi></mml:math>activation can target cancer cells energy balance by blocking fatty acid synthesis and by promoting fatty acid<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>β</mml:mi></mml:math>-oxidation. In the state of limited nutrient availability, frequently presents in the tumor microenvironment, PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>α</mml:mi></mml:math>cooperates with AMP-dependent protein kinase in: (i) repressing oncogenic Akt activity, (ii) inhibiting cell proliferation, and (iii) forcing glycolysis-dependent cancer cells into “metabolic catastrophe.” Other potential anticancer effects of PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>α</mml:mi></mml:math>include suppression of inflammation, and upregulation of uncoupling proteins (UCPs), which attenuates mitochondrial reactive oxygen species production and cell proliferation. In conclusion, there are strong premises that the low-toxic and well-tolerated PPAR ligands should be considered as new therapeutic agents to fight disseminating cancer, which represents the major challenge for modern medicine and basic research." @default.
- W2051243140 created "2016-06-24" @default.
- W2051243140 creator A5007156585 @default.
- W2051243140 creator A5068495176 @default.
- W2051243140 date "2008-01-01" @default.
- W2051243140 modified "2023-09-25" @default.
- W2051243140 title "Anticancer Properties of PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>α</mml:mi></mml:math>-Effects on Cellular Metabolism and Inflammation" @default.
- W2051243140 cites W1481314844 @default.
- W2051243140 cites W1488739175 @default.
- W2051243140 cites W1506249422 @default.
- W2051243140 cites W1567127662 @default.
- W2051243140 cites W1579890798 @default.
- W2051243140 cites W1591517987 @default.
- W2051243140 cites W1818080689 @default.
- W2051243140 cites W1890869374 @default.
- W2051243140 cites W1942855627 @default.
- W2051243140 cites W1964353872 @default.
- W2051243140 cites W1969384498 @default.
- W2051243140 cites W1969876145 @default.
- W2051243140 cites W1974567967 @default.
- W2051243140 cites W1974678207 @default.
- W2051243140 cites W1975515886 @default.
- W2051243140 cites W1978736810 @default.
- W2051243140 cites W1981101682 @default.
- W2051243140 cites W1989002053 @default.
- W2051243140 cites W1991238715 @default.
- W2051243140 cites W1991914994 @default.
- W2051243140 cites W1999391010 @default.
- W2051243140 cites W2006574739 @default.
- W2051243140 cites W2008523969 @default.
- W2051243140 cites W2012420821 @default.
- W2051243140 cites W2017583197 @default.
- W2051243140 cites W2019789647 @default.
- W2051243140 cites W2021724668 @default.
- W2051243140 cites W2023806016 @default.
- W2051243140 cites W2023819606 @default.
- W2051243140 cites W2027584688 @default.
- W2051243140 cites W2034035188 @default.
- W2051243140 cites W2034872735 @default.
- W2051243140 cites W2039731227 @default.
- W2051243140 cites W2041319301 @default.
- W2051243140 cites W2041618682 @default.
- W2051243140 cites W2045962235 @default.
- W2051243140 cites W2046403598 @default.
- W2051243140 cites W2046998382 @default.
- W2051243140 cites W2047399305 @default.
- W2051243140 cites W2051020893 @default.
- W2051243140 cites W2053859498 @default.
- W2051243140 cites W2054017411 @default.
- W2051243140 cites W2056246818 @default.
- W2051243140 cites W2060041328 @default.
- W2051243140 cites W2062515127 @default.
- W2051243140 cites W2065133286 @default.
- W2051243140 cites W2066465207 @default.
- W2051243140 cites W2066800765 @default.
- W2051243140 cites W2072451938 @default.
- W2051243140 cites W2074297921 @default.
- W2051243140 cites W2074888484 @default.
- W2051243140 cites W2075065864 @default.
- W2051243140 cites W2082853003 @default.
- W2051243140 cites W20888715 @default.
- W2051243140 cites W2094395583 @default.
- W2051243140 cites W2097192370 @default.
- W2051243140 cites W2100433915 @default.
- W2051243140 cites W2101142723 @default.
- W2051243140 cites W2104492370 @default.
- W2051243140 cites W2108212852 @default.
- W2051243140 cites W2117275311 @default.
- W2051243140 cites W2121489914 @default.
- W2051243140 cites W2121727754 @default.
- W2051243140 cites W2123014930 @default.
- W2051243140 cites W2129916963 @default.
- W2051243140 cites W2133000461 @default.
- W2051243140 cites W2136748154 @default.
- W2051243140 cites W2139409926 @default.
- W2051243140 cites W2144147514 @default.
- W2051243140 cites W2145906784 @default.
- W2051243140 cites W2150256240 @default.
- W2051243140 cites W2157101941 @default.
- W2051243140 cites W2157639204 @default.
- W2051243140 cites W2164098551 @default.
- W2051243140 cites W2164300744 @default.
- W2051243140 cites W2169520827 @default.
- W2051243140 cites W2170088667 @default.
- W2051243140 cites W2388163742 @default.
- W2051243140 cites W4246811033 @default.
- W2051243140 cites W4248880909 @default.
- W2051243140 cites W4251516326 @default.
- W2051243140 cites W4319308571 @default.
- W2051243140 doi "https://doi.org/10.1155/2008/930705" @default.
- W2051243140 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2396219" @default.
- W2051243140 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18509489" @default.
- W2051243140 hasPublicationYear "2008" @default.
- W2051243140 type Work @default.
- W2051243140 sameAs 2051243140 @default.
- W2051243140 citedByCount "55" @default.
- W2051243140 countsByYear W20512431402012 @default.
- W2051243140 countsByYear W20512431402013 @default.