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- W2051244685 endingPage "85" @default.
- W2051244685 startingPage "57" @default.
- W2051244685 abstract "The contact system (CAS) is part of the coagulation system, consisting of a group of plasma proteins stimulating inflammation, coagulation, and fibrinolysis when activated. CAS can be triggered by several activating surfaces, and CAS may play a potential role in thrombus formation. Combined oral contraceptives (COCs) are known to increase the risk of venous thromboembolism, and COCs induce various prothrombotic changes in the coagulation system, whereas the effect of COC on CAS has not been thoroughly investigated.To investigate CAS in COC users compared with nonusers.Blood samples from 62 study subjects, 30 COC users, and 32 nonusers, were analyzed. Coagulation factor XII (FXII), prekallikrein (PK), H-Kininogen (HK), cleaved HK (cHK), C1-esterase inhibitor (C1-inh), and the endogenous kallikrein potential (EKP) were measured.COC users had significantly higher FXII (median, 38.4 vs 28.9 mg/L) and lower C1-inh levels (0.20 vs 0.23 g/L) than nonusers. The levels of PK and HK were not significantly different. Measurement of EKP indicated an increased capacity of CAS in COC users (1860 vs 1500 nmol/L × min), and increased plasma levels of cHK (2.02 vs 1.07 μg/L) indicated an increased activity in vivo.This study demonstrates an increased CAS capacity in women using COC compared with nonusers and also an increased activity in vivo. The results indicate that increased contact activation may contribute to the increased thrombotic risk caused by COC." @default.
- W2051244685 created "2016-06-24" @default.
- W2051244685 creator A5045639353 @default.
- W2051244685 creator A5066630966 @default.
- W2051244685 creator A5069143752 @default.
- W2051244685 date "1986-01-01" @default.
- W2051244685 modified "2023-10-18" @default.
- W2051244685 title "The contact activation system: Biochemistry and interactions of these surface-mediated defense reactions" @default.
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