FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051244860> ?p ?o ?g. }

• W2051244860 endingPage "1635" @default.
• W2051244860 startingPage "1629" @default.
• W2051244860 abstract "Preeclampsia is a serious pathologic complication during pregnancy, and its pathogenesis remains poorly understood. Recent studies have demonstrated that autoantibodies against angiotensin II type 1A receptor (AT1-AA) are present in women with preeclampsia. However, their role in the development of hypertension in preeclamptic patients has never been previously investigated. The present study was designed to determine whether AT1-AA isolated from the sera of preeclamptic patients causes vascular constriction and, if so, to further investigate the cellular receptors that mediate their vasoactivity. Blood samples were collected from 49 pregnant women (preeclampsia = 31, control = 18) and AT1-AA was detected using enzyme-linked immunosorbent assay. Vasoconstrictive effect of purified IgG from the sera of either preeclamptic patients or normal pregnant women was determined in isolated rat thoracic aorta, arteriae cerebri media and coronary artery. Compared with normal pregnant women, frequency of AT1-AA positive samples was markedly increased in preeclamptic patients (80.7 vs. 5.6%, P < 0.01). In isolated thoracic aortic rings, middle cerebral artery and coronary artery segments, AT1-AA induced vasoconstriction in a concentration-dependent fashion (P < 0.01). The vasoconstrictive effect of AT1-AA was completely blocked by losartan, an AT1-receptor antagonist. These data demonstrate that the AT1-AA causes significant vascular constriction in large conduit vessel as well as small resistant vessels though activation of the AT1 receptor. These results suggest that overproduction of AT1-AA is a novel risk factor in pregnant women and may play a causative role in the development of hypertension and vascular injury in preeclamptic patients." @default.
• W2051244860 created "2016-06-24" @default.
• W2051244860 creator A5010056282 @default.
• W2051244860 creator A5011791931 @default.
• W2051244860 creator A5028051166 @default.
• W2051244860 creator A5031874278 @default.
• W2051244860 creator A5041598430 @default.
• W2051244860 creator A5046831678 @default.
• W2051244860 creator A5053882190 @default.
• W2051244860 creator A5070756036 @default.
• W2051244860 creator A5070812231 @default.
• W2051244860 creator A5071994713 @default.
• W2051244860 date "2008-08-01" @default.
• W2051244860 modified "2023-09-27" @default.
• W2051244860 title "Autoantibody against AT1 receptor from preeclamptic patients induces vasoconstriction through angiotensin receptor activation" @default.
• W2051244860 cites W1479945039 @default.
• W2051244860 cites W1965512249 @default.
• W2051244860 cites W1998290030 @default.
• W2051244860 cites W2009813800 @default.
• W2051244860 cites W2014871892 @default.
• W2051244860 cites W2022899332 @default.
• W2051244860 cites W2027946040 @default.
• W2051244860 cites W2041517672 @default.
• W2051244860 cites W2045908881 @default.
• W2051244860 cites W2062975073 @default.
• W2051244860 cites W2073579835 @default.
• W2051244860 cites W2089162288 @default.
• W2051244860 cites W2089221056 @default.
• W2051244860 cites W2097417946 @default.
• W2051244860 cites W2140785684 @default.
• W2051244860 cites W2145729033 @default.
• W2051244860 cites W2155394014 @default.
• W2051244860 cites W2160705469 @default.
• W2051244860 cites W2164878633 @default.
• W2051244860 cites W2169226096 @default.
• W2051244860 cites W2171162078 @default.
• W2051244860 cites W4242472190 @default.
• W2051244860 doi "https://doi.org/10.1097/hjh.0b013e328304dbff" @default.
• W2051244860 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18622242" @default.
• W2051244860 hasPublicationYear "2008" @default.
• W2051244860 type Work @default.
• W2051244860 sameAs 2051244860 @default.
• W2051244860 citedByCount "62" @default.
• W2051244860 countsByYear W20512448602012 @default.
• W2051244860 countsByYear W20512448602013 @default.
• W2051244860 countsByYear W20512448602014 @default.
• W2051244860 countsByYear W20512448602015 @default.
• W2051244860 countsByYear W20512448602016 @default.
• W2051244860 countsByYear W20512448602017 @default.
• W2051244860 countsByYear W20512448602018 @default.
• W2051244860 countsByYear W20512448602019 @default.
• W2051244860 countsByYear W20512448602020 @default.
• W2051244860 countsByYear W20512448602021 @default.
• W2051244860 countsByYear W20512448602022 @default.
• W2051244860 countsByYear W20512448602023 @default.
• W2051244860 crossrefType "journal-article" @default.
• W2051244860 hasAuthorship W2051244860A5010056282 @default.
• W2051244860 hasAuthorship W2051244860A5011791931 @default.
• W2051244860 hasAuthorship W2051244860A5028051166 @default.
• W2051244860 hasAuthorship W2051244860A5031874278 @default.
• W2051244860 hasAuthorship W2051244860A5041598430 @default.
• W2051244860 hasAuthorship W2051244860A5046831678 @default.
• W2051244860 hasAuthorship W2051244860A5053882190 @default.
• W2051244860 hasAuthorship W2051244860A5070756036 @default.
• W2051244860 hasAuthorship W2051244860A5070812231 @default.
• W2051244860 hasAuthorship W2051244860A5071994713 @default.
• W2051244860 hasConcept C123915805 @default.
• W2051244860 hasConcept C126322002 @default.
• W2051244860 hasConcept C134018914 @default.
• W2051244860 hasConcept C170493617 @default.
• W2051244860 hasConcept C2777218350 @default.
• W2051244860 hasConcept C2779234561 @default.
• W2051244860 hasConcept C2779961880 @default.
• W2051244860 hasConcept C2779980429 @default.
• W2051244860 hasConcept C2780288358 @default.
• W2051244860 hasConcept C2780942790 @default.
• W2051244860 hasConcept C2908929049 @default.
• W2051244860 hasConcept C54355233 @default.
• W2051244860 hasConcept C71924100 @default.
• W2051244860 hasConcept C86803240 @default.
• W2051244860 hasConceptScore W2051244860C123915805 @default.
• W2051244860 hasConceptScore W2051244860C126322002 @default.
• W2051244860 hasConceptScore W2051244860C134018914 @default.
• W2051244860 hasConceptScore W2051244860C170493617 @default.
• W2051244860 hasConceptScore W2051244860C2777218350 @default.
• W2051244860 hasConceptScore W2051244860C2779234561 @default.
• W2051244860 hasConceptScore W2051244860C2779961880 @default.
• W2051244860 hasConceptScore W2051244860C2779980429 @default.
• W2051244860 hasConceptScore W2051244860C2780288358 @default.
• W2051244860 hasConceptScore W2051244860C2780942790 @default.
• W2051244860 hasConceptScore W2051244860C2908929049 @default.
• W2051244860 hasConceptScore W2051244860C54355233 @default.
• W2051244860 hasConceptScore W2051244860C71924100 @default.
• W2051244860 hasConceptScore W2051244860C86803240 @default.
• W2051244860 hasIssue "8" @default.
• W2051244860 hasLocation W20512448601 @default.
• W2051244860 hasLocation W20512448602 @default.
• W2051244860 hasOpenAccess W2051244860 @default.

• next