FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051245381> ?p ?o ?g. }

• W2051245381 endingPage "45" @default.
• W2051245381 startingPage "38" @default.
• W2051245381 abstract "Brain preconditioning refers to a wide range of treatments that induce a neuronal tolerance state where neuronal tissue become more resistant to a subsequent lethal insult. The mechanisms underlying the preconditioning-induced brain tolerance are not fully understood, but up-regulation of antioxidant enzymes activity has been suggested to play an important role. In order to test this hypothesis, evaluation of glutathione (GSH) scavenger system was carried out in mice showing the neuroprotective effect of NMDA preconditioning against quinolinic acid (QA)-induced seizures. NMDA is known to prevent seizures in 53% of the animals and completely prevent neural damage against QA. Mice were preconditioned by a non-convulsant NMDA dose (75 mg/kg, 10 ml/kg i.p.) 24 h before QA infusion (4 microl, 9.2 mM i.c.v.). GSH content and enzymatic activities of glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST) and glucose-6-phosphate dehydrogenase (G6PDH) were evaluated in the cerebral cortex and hippocampus 24 h after QA infusion. NMDA preconditioning and QA infusion did not alter GSH content, GR and G6PDH activities, however, an increase in GST activity was observed in the cerebral cortex from mice. Moreover, NMDA pretreatment was able to prevent the QA-induced decrease in hippocampal GPx activity, but it was not effective against the decreased cortical GPx activity. These results indicate that, although NMDA preconditioning and QA toxicity modulate the activity of some GSH related enzymes, GSH metabolism is not directly linked to the neuroprotective effect induced by NMDA preconditioning." @default.
• W2051245381 created "2016-06-24" @default.
• W2051245381 creator A5007004833 @default.
• W2051245381 creator A5018122907 @default.
• W2051245381 creator A5033712903 @default.
• W2051245381 creator A5066053735 @default.
• W2051245381 creator A5076970656 @default.
• W2051245381 creator A5083882054 @default.
• W2051245381 date "2007-12-01" @default.
• W2051245381 modified "2023-10-16" @default.
• W2051245381 title "Evaluation of glutathione metabolism in NMDA preconditioning against quinolinic acid-induced seizures in mice cerebral cortex and hippocampus" @default.
• W2051245381 cites W1122013619 @default.
• W2051245381 cites W1479729971 @default.
• W2051245381 cites W1493772670 @default.
• W2051245381 cites W1498636565 @default.
• W2051245381 cites W1575495254 @default.
• W2051245381 cites W1641976814 @default.
• W2051245381 cites W1858816790 @default.
• W2051245381 cites W1943595560 @default.
• W2051245381 cites W1970441623 @default.
• W2051245381 cites W1970799273 @default.
• W2051245381 cites W1971261279 @default.
• W2051245381 cites W1978183586 @default.
• W2051245381 cites W1978956024 @default.
• W2051245381 cites W1981757532 @default.
• W2051245381 cites W1982554377 @default.
• W2051245381 cites W1989971741 @default.
• W2051245381 cites W2003337582 @default.
• W2051245381 cites W2005796936 @default.
• W2051245381 cites W2007064404 @default.
• W2051245381 cites W2009113415 @default.
• W2051245381 cites W2009812062 @default.
• W2051245381 cites W2010906979 @default.
• W2051245381 cites W2011296674 @default.
• W2051245381 cites W2018044686 @default.
• W2051245381 cites W2022499907 @default.
• W2051245381 cites W2025479383 @default.
• W2051245381 cites W2029603067 @default.
• W2051245381 cites W2031020747 @default.
• W2051245381 cites W2032584011 @default.
• W2051245381 cites W2033792203 @default.
• W2051245381 cites W2040845281 @default.
• W2051245381 cites W2041915244 @default.
• W2051245381 cites W2043506485 @default.
• W2051245381 cites W2043966868 @default.
• W2051245381 cites W2046668300 @default.
• W2051245381 cites W2046913442 @default.
• W2051245381 cites W2056195483 @default.
• W2051245381 cites W2061611794 @default.
• W2051245381 cites W2063175209 @default.
• W2051245381 cites W2065463296 @default.
• W2051245381 cites W2070437466 @default.
• W2051245381 cites W2074919593 @default.
• W2051245381 cites W2078352512 @default.
• W2051245381 cites W2085156996 @default.
• W2051245381 cites W2085491750 @default.
• W2051245381 cites W2089276909 @default.
• W2051245381 cites W2116113384 @default.
• W2051245381 cites W2130031072 @default.
• W2051245381 cites W2136959981 @default.
• W2051245381 cites W2163418315 @default.
• W2051245381 cites W2171864779 @default.
• W2051245381 cites W2197332903 @default.
• W2051245381 cites W2413412002 @default.
• W2051245381 cites W4293247451 @default.
• W2051245381 cites W848351976 @default.
• W2051245381 doi "https://doi.org/10.1016/j.brainres.2007.09.091" @default.
• W2051245381 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17980354" @default.
• W2051245381 hasPublicationYear "2007" @default.
• W2051245381 type Work @default.
• W2051245381 sameAs 2051245381 @default.
• W2051245381 citedByCount "27" @default.
• W2051245381 countsByYear W20512453812012 @default.
• W2051245381 countsByYear W20512453812013 @default.
• W2051245381 countsByYear W20512453812014 @default.
• W2051245381 countsByYear W20512453812015 @default.
• W2051245381 countsByYear W20512453812016 @default.
• W2051245381 countsByYear W20512453812018 @default.
• W2051245381 countsByYear W20512453812019 @default.
• W2051245381 countsByYear W20512453812021 @default.
• W2051245381 countsByYear W20512453812022 @default.
• W2051245381 crossrefType "journal-article" @default.
• W2051245381 hasAuthorship W2051245381A5007004833 @default.
• W2051245381 hasAuthorship W2051245381A5018122907 @default.
• W2051245381 hasAuthorship W2051245381A5033712903 @default.
• W2051245381 hasAuthorship W2051245381A5066053735 @default.
• W2051245381 hasAuthorship W2051245381A5076970656 @default.
• W2051245381 hasAuthorship W2051245381A5083882054 @default.
• W2051245381 hasConcept C165069038 @default.
• W2051245381 hasConcept C170493617 @default.
• W2051245381 hasConcept C181199279 @default.
• W2051245381 hasConcept C185592680 @default.
• W2051245381 hasConcept C25498285 @default.
• W2051245381 hasConcept C2776706248 @default.
• W2051245381 hasConcept C2777896816 @default.
• W2051245381 hasConcept C2778760513 @default.
• W2051245381 hasConcept C2778900099 @default.
• W2051245381 hasConcept C2781012912 @default.

• next