Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051245456> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2051245456 abstract "To predict the cost-effectiveness of lamotrigine by evaluating the costs and health outcomes in treated patients.Lamotrigine adjunctive therapy has been found to be associated with decreased seizure frequency and severity in patients who are refractory to treatment with the older antiepileptic drugs (AEDs).We used a cost-effectiveness clinical decision analysis framework to assess the impact of these clinical benefits on patient health care use. The measure of effectiveness was seizure-free days gained. The measures of health care resource use included hospitalizations, outpatient and emergency department visits, surgery, and AEDs. Medical care use and cost estimates were derived from clinical trial data and published sources. Costs and effectiveness (incremental costs per seizure-free days gained) of lamotrigine adjunctive therapy versus older AEDs were compared in patients refractory to previous treatment during three time periods: the start-up year, the second year when decisions about surgery were made, and all subsequent years.The model predicts that use of lamotrigine would be associated with an overall reduction in use of other direct medical care resources (hospitalizations, outpatient visits, diagnostic and laboratory tests, and surgery). For a 10-year time horizon, the estimated cost-effectiveness ratio is $6.9 per seizure-free day gained. The model provides a flexible framework to analyze the effect of new antiepileptic drugs." @default.
- W2051245456 created "2016-06-24" @default.
- W2051245456 creator A5010807403 @default.
- W2051245456 creator A5072861207 @default.
- W2051245456 creator A5085070252 @default.
- W2051245456 date "1998-10-01" @default.
- W2051245456 modified "2023-10-16" @default.
- W2051245456 title "Cost-effectiveness model of adjunctive lamotrigine for the treatment of epilepsy" @default.
- W2051245456 cites W1981126050 @default.
- W2051245456 cites W2337305755 @default.
- W2051245456 doi "https://doi.org/10.1212/wnl.51.4.1026" @default.
- W2051245456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9781524" @default.
- W2051245456 hasPublicationYear "1998" @default.
- W2051245456 type Work @default.
- W2051245456 sameAs 2051245456 @default.
- W2051245456 citedByCount "31" @default.
- W2051245456 countsByYear W20512454562012 @default.
- W2051245456 countsByYear W20512454562013 @default.
- W2051245456 countsByYear W20512454562021 @default.
- W2051245456 crossrefType "journal-article" @default.
- W2051245456 hasAuthorship W2051245456A5010807403 @default.
- W2051245456 hasAuthorship W2051245456A5072861207 @default.
- W2051245456 hasAuthorship W2051245456A5085070252 @default.
- W2051245456 hasConcept C112930515 @default.
- W2051245456 hasConcept C118552586 @default.
- W2051245456 hasConcept C121332964 @default.
- W2051245456 hasConcept C126322002 @default.
- W2051245456 hasConcept C142424586 @default.
- W2051245456 hasConcept C160735492 @default.
- W2051245456 hasConcept C162324750 @default.
- W2051245456 hasConcept C177713679 @default.
- W2051245456 hasConcept C194828623 @default.
- W2051245456 hasConcept C2778186239 @default.
- W2051245456 hasConcept C2778802184 @default.
- W2051245456 hasConcept C2780724011 @default.
- W2051245456 hasConcept C3018162438 @default.
- W2051245456 hasConcept C3019080777 @default.
- W2051245456 hasConcept C50522688 @default.
- W2051245456 hasConcept C535046627 @default.
- W2051245456 hasConcept C71924100 @default.
- W2051245456 hasConcept C87355193 @default.
- W2051245456 hasConceptScore W2051245456C112930515 @default.
- W2051245456 hasConceptScore W2051245456C118552586 @default.
- W2051245456 hasConceptScore W2051245456C121332964 @default.
- W2051245456 hasConceptScore W2051245456C126322002 @default.
- W2051245456 hasConceptScore W2051245456C142424586 @default.
- W2051245456 hasConceptScore W2051245456C160735492 @default.
- W2051245456 hasConceptScore W2051245456C162324750 @default.
- W2051245456 hasConceptScore W2051245456C177713679 @default.
- W2051245456 hasConceptScore W2051245456C194828623 @default.
- W2051245456 hasConceptScore W2051245456C2778186239 @default.
- W2051245456 hasConceptScore W2051245456C2778802184 @default.
- W2051245456 hasConceptScore W2051245456C2780724011 @default.
- W2051245456 hasConceptScore W2051245456C3018162438 @default.
- W2051245456 hasConceptScore W2051245456C3019080777 @default.
- W2051245456 hasConceptScore W2051245456C50522688 @default.
- W2051245456 hasConceptScore W2051245456C535046627 @default.
- W2051245456 hasConceptScore W2051245456C71924100 @default.
- W2051245456 hasConceptScore W2051245456C87355193 @default.
- W2051245456 hasLocation W20512454561 @default.
- W2051245456 hasLocation W20512454562 @default.
- W2051245456 hasOpenAccess W2051245456 @default.
- W2051245456 hasPrimaryLocation W20512454561 @default.
- W2051245456 hasRelatedWork W1970021043 @default.
- W2051245456 hasRelatedWork W2010281261 @default.
- W2051245456 hasRelatedWork W2166543123 @default.
- W2051245456 hasRelatedWork W2361289554 @default.
- W2051245456 hasRelatedWork W2382770367 @default.
- W2051245456 hasRelatedWork W2405131795 @default.
- W2051245456 hasRelatedWork W2410576837 @default.
- W2051245456 hasRelatedWork W2413698536 @default.
- W2051245456 hasRelatedWork W2417989913 @default.
- W2051245456 hasRelatedWork W2440200988 @default.
- W2051245456 isParatext "false" @default.
- W2051245456 isRetracted "false" @default.
- W2051245456 magId "2051245456" @default.
- W2051245456 workType "article" @default.