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- W2051245722 abstract "The neural cell adhesion molecule (NCAM) plays a crucial role in stress-related brain function, emotional behavior and memory formation. In this study, we investigated the functions of the glucocorticoid and serotonergic systems in mice constitutively deficient for NCAM (NCAM−/− mice). Our data provide evidence for a hyperfunction of the hypothalamic–pituitary–adrenal axis, with enlarged adrenal glands and increased stress-induced corticosterone release, but reduced hippocampal glucocorticoid receptor expression in NCAM−/− mice when compared to NCAM+/+ mice. We also obtained evidence for a hypofunction of 5-HT1A autoreceptors as indicated by increased 8-0H-DPAT-induced hypothermia. These findings suggest a disturbance of both humoral and neural stress systems in NCAM−/− mice. Accordingly, we not only confirmed previously observed hyperarousal of NCAM−/− mice in various anxiety tests, but also observed an increased response to novelty exposure in these animals. Spatial learning deficits of the NCAM−/− mice in a Morris Water maze persisted, even when mice were pretrained to prevent effects of novelty or stress. We suggest that NCAM-mediated processes are involved in both novelty/stress-related emotional behavior and in cognitive function during spatial learning." @default.
- W2051245722 created "2016-06-24" @default.
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- W2051245722 date "2013-09-03" @default.
- W2051245722 modified "2023-09-23" @default.
- W2051245722 title "Role of stress system disturbance and enhanced novelty response in spatial learning of NCAM-deficient mice" @default.
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- W2051245722 doi "https://doi.org/10.3109/10253890.2013.840773" @default.
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