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• W2051247011 startingPage "631" @default.
• W2051247011 abstract "Brown recluse spider (Loxosceles reclusa) venom induces severe dermonecrotic lesions. The mechanism for this is unknown but presents an interesting paradox: necrosis is completely dependent on the victim's neutrophils, yet neutrophils are not activated by the venom. We show Loxosceles venom is a potent, but disjointed, endothelial cell agonist. It weakly induced E-selectin expression, but not intercellular adhesion molecule-1 or IL-6 expression, yet significantly stimulated release of IL-8 and large amounts of GM-CSF by 4 h. In contrast, TNF strongly induced all of these, except for GM-CSF. PMN bound to E-selectin on venom-activated endothelial cells, apparently via counterreceptors different from those that bind E-selectin on TNF alpha-activated monolayers. Notably, PMN bound venom-activated monolayers only at intercellular junctions, did not polarize, and completely failed to migrate beneath the monolayer. Despite this, bound PMN demonstrated increased intracellular Ca2+ levels and secreted primary and secondary granule markers. The latter event was suppressed by sulfones used to treat envenomation. We have defined a new endothelial cell agonist, Loxosceles venom, that differentially stimulates the inflammatory response of endothelial cells. This, in turn, leads to a dysregulated PMN response where adhesion and degranulation are completely dissociated from shape change and transmigration." @default.
• W2051247011 created "2016-06-24" @default.
• W2051247011 creator A5002690026 @default.
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• W2051247011 creator A5019289575 @default.
• W2051247011 creator A5033101588 @default.
• W2051247011 creator A5090473064 @default.
• W2051247011 date "1994-08-01" @default.
• W2051247011 modified "2023-10-11" @default.
• W2051247011 title "The necrotic venom of the brown recluse spider induces dysregulated endothelial cell-dependent neutrophil activation. Differential induction of GM-CSF, IL-8, and E-selectin expression." @default.
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• W2051247011 doi "https://doi.org/10.1172/jci117379" @default.
• W2051247011 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/296140" @default.
• W2051247011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7518841" @default.
• W2051247011 hasPublicationYear "1994" @default.
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