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- W2051247655 abstract "Bradykinin (BK) isolated from plasma of the African lungfish, Protopterus annectens, contains four amino acid substitutions compared with BK from mammals (Arg1→Tyr, Pro2→Gly, Pro7→Ala, Phe8→Pro). Bolus intra-arterial injections of synthetic lungfish BK (1–1000 pmol/kg body wt.) into unanaesthetised, juvenile lungfish (n=5) produced a dose-dependent increase in arterial blood pressure and pulse pressure. The maximum pressor response occurred 2–3 min after injection and persisted for up to 15 min. The threshold dose producing a significant (P<0.01) rise in pressure was 50 pmol/kg and the maximum increase, following injection of 300 pmol/kg, was 9.3±2.3 mmHg. Injection of the higher doses of lungfish BK produced a significant (P<0.05) increase in heart rate (2.8±0.8 beats/min at 100 pmol/kg). In contrast, bolus intra-arterial injections of mammalian BK, in doses up to 1000 pmol/kg, produced no significant cardiovascular effects in the lungfish. The data support the existence of a functioning kallikrein–kinin system in the lungfish and demonstrate that the ligand-binding properties of the receptor(s) mediating the cardiovascular actions of lungfish BK are appreciably different from mammalian B1 and B2 receptors." @default.
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- W2051247655 date "2002-02-01" @default.
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- W2051247655 title "Cardiovascular actions of lungfish bradykinin in the unanaesthetised African lungfish, Protopterus annectens" @default.
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- W2051247655 doi "https://doi.org/10.1016/s1095-6433(01)00486-x" @default.
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