FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051247780> ?p ?o ?g. }

• W2051247780 endingPage "389" @default.
• W2051247780 startingPage "381" @default.
• W2051247780 abstract "The present study examined mu and delta opioid analgesia, receptor binding, and receptor mRNA levels in lines of mice from two selective breeding projects of relevance to opioid analgesia. Large differences were observed in the analgesic potency of [d-Ala2, NMPhe4, Gly-ol]enkephalin (DAMGO), [d-Pen2,5]enkephalin (DPDPE), and [d-Ala2]deltorphin II (DELT), selective mu, delta1, and delta2 opioid receptor agonists, respectively, in mice selectively bred for high (HA) and low (LA) swim stress-induced analgesia (SIA). HAR and LAR mice, selectively bred for high and low levorphanol analgesia, respectively, display equally large differences in their analgesic sensitivity to DAMGO, modest differences in sensitivity to DPDPE, and no differences in sensitivity to DELT. These sizable genotypic differences in analgesic potency were accompanied by HA/LA and HAR/LAR differences in whole-brain homogenate [3H]DPDPE and/or [3H]DELT, but paradoxically not [3H]DAMGO, binding. Solution hybridization of mRNA extracts encoding mu (MOR-1) or delta (DOR-1) opioid receptors indicated some regional differences in gene expression between high and low lines. Surprisingly, differences in these in vitro markers were often in the direction of LAR>HAR. The present data indicate that selection for either SSIA or levorphanol analgesia produces differential effects on mu and delta opioid analgesia that are accompanied by alterations on in vitro assays, the significance of which remains to be determined. The data are discussed with regard to the utility of in vitro biological markers and genetic models of analgesia." @default.
• W2051247780 created "2016-06-24" @default.
• W2051247780 creator A5005776897 @default.
• W2051247780 creator A5034093262 @default.
• W2051247780 creator A5053304883 @default.
• W2051247780 creator A5067118176 @default.
• W2051247780 creator A5071548414 @default.
• W2051247780 creator A5072903338 @default.
• W2051247780 creator A5068093441 @default.
• W2051247780 date "1999-01-01" @default.
• W2051247780 modified "2023-09-24" @default.
• W2051247780 title "Mu and delta opioid receptor analgesia, binding density, and mRNA levels in mice selectively bred for high and low analgesia" @default.
• W2051247780 cites W133237663 @default.
• W2051247780 cites W1775749144 @default.
• W2051247780 cites W1969553615 @default.
• W2051247780 cites W1974759190 @default.
• W2051247780 cites W1975636294 @default.
• W2051247780 cites W1977250625 @default.
• W2051247780 cites W1982562901 @default.
• W2051247780 cites W1991992618 @default.
• W2051247780 cites W1997771816 @default.
• W2051247780 cites W1998353670 @default.
• W2051247780 cites W1999350661 @default.
• W2051247780 cites W2000014496 @default.
• W2051247780 cites W2005599686 @default.
• W2051247780 cites W2011880148 @default.
• W2051247780 cites W2019249019 @default.
• W2051247780 cites W2024897830 @default.
• W2051247780 cites W2030325954 @default.
• W2051247780 cites W2037092812 @default.
• W2051247780 cites W2038618141 @default.
• W2051247780 cites W2038991827 @default.
• W2051247780 cites W2039423720 @default.
• W2051247780 cites W2041395144 @default.
• W2051247780 cites W2045112376 @default.
• W2051247780 cites W2045678324 @default.
• W2051247780 cites W2052049922 @default.
• W2051247780 cites W2060517883 @default.
• W2051247780 cites W2064037736 @default.
• W2051247780 cites W2067084650 @default.
• W2051247780 cites W2067265958 @default.
• W2051247780 cites W2076577844 @default.
• W2051247780 cites W2079214445 @default.
• W2051247780 cites W2085514581 @default.
• W2051247780 cites W2086707579 @default.
• W2051247780 cites W2123466824 @default.
• W2051247780 cites W2135117278 @default.
• W2051247780 cites W2138512124 @default.
• W2051247780 cites W2140257707 @default.
• W2051247780 doi "https://doi.org/10.1016/s0006-8993(98)01141-x" @default.
• W2051247780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9878841" @default.
• W2051247780 hasPublicationYear "1999" @default.
• W2051247780 type Work @default.
• W2051247780 sameAs 2051247780 @default.
• W2051247780 citedByCount "32" @default.
• W2051247780 countsByYear W20512477802013 @default.
• W2051247780 countsByYear W20512477802015 @default.
• W2051247780 countsByYear W20512477802017 @default.
• W2051247780 countsByYear W20512477802019 @default.
• W2051247780 countsByYear W20512477802021 @default.
• W2051247780 crossrefType "journal-article" @default.
• W2051247780 hasAuthorship W2051247780A5005776897 @default.
• W2051247780 hasAuthorship W2051247780A5034093262 @default.
• W2051247780 hasAuthorship W2051247780A5053304883 @default.
• W2051247780 hasAuthorship W2051247780A5067118176 @default.
• W2051247780 hasAuthorship W2051247780A5068093441 @default.
• W2051247780 hasAuthorship W2051247780A5071548414 @default.
• W2051247780 hasAuthorship W2051247780A5072903338 @default.
• W2051247780 hasConcept C126322002 @default.
• W2051247780 hasConcept C134018914 @default.
• W2051247780 hasConcept C141087196 @default.
• W2051247780 hasConcept C14397066 @default.
• W2051247780 hasConcept C170493617 @default.
• W2051247780 hasConcept C185592680 @default.
• W2051247780 hasConcept C2776401185 @default.
• W2051247780 hasConcept C2777515746 @default.
• W2051247780 hasConcept C2777803847 @default.
• W2051247780 hasConcept C2778750930 @default.
• W2051247780 hasConcept C2779248205 @default.
• W2051247780 hasConcept C2779886867 @default.
• W2051247780 hasConcept C2780820201 @default.
• W2051247780 hasConcept C2781063702 @default.
• W2051247780 hasConcept C55493867 @default.
• W2051247780 hasConcept C71924100 @default.
• W2051247780 hasConcept C86803240 @default.
• W2051247780 hasConcept C98274493 @default.
• W2051247780 hasConceptScore W2051247780C126322002 @default.
• W2051247780 hasConceptScore W2051247780C134018914 @default.
• W2051247780 hasConceptScore W2051247780C141087196 @default.
• W2051247780 hasConceptScore W2051247780C14397066 @default.
• W2051247780 hasConceptScore W2051247780C170493617 @default.
• W2051247780 hasConceptScore W2051247780C185592680 @default.
• W2051247780 hasConceptScore W2051247780C2776401185 @default.
• W2051247780 hasConceptScore W2051247780C2777515746 @default.
• W2051247780 hasConceptScore W2051247780C2777803847 @default.
• W2051247780 hasConceptScore W2051247780C2778750930 @default.
• W2051247780 hasConceptScore W2051247780C2779248205 @default.
• W2051247780 hasConceptScore W2051247780C2779886867 @default.

• next