Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051248004> ?p ?o ?g. }
- W2051248004 endingPage "1872" @default.
- W2051248004 startingPage "1866" @default.
- W2051248004 abstract "Photolyase repairs ultraviolet (UV) damage to DNA by splitting the cyclobutane ring of the major UV photoproduct, the cis, syn-cyclobutane pyrimidine dimer (Pyr <> Pyr). The reaction is initiated by blue light and proceeds through long-range energy transfer, single electron transfer, and enzyme catalysis by a radical mechanism. The three-dimensional crystallographic structure of DNA photolyase from Escherichia coli is presented and the atomic model was refined to an R value of 0.172 at 2.3 A resolution. The polypeptide chain of 471 amino acids is folded into an amino-terminal alpha/beta domain resembling dinucleotide binding domains and a carboxyl-terminal helical domain; a loop of 72 residues connects the domains. The light-harvesting cofactor 5,10-methenyltetrahydrofolylpolyglutamate (MTHF) binds in a cleft between the two domains. Energy transfer from MTHF to the catalytic cofactor flavin adenine dinucleotide (FAD) occurs over a distance of 16.8 A. The FAD adopts a U-shaped conformation between two helix clusters in the center of the helical domain and is accessible through a hole in the surface of this domain. Dimensions and polarity of the hole match those of a Pyr <> Pyr dinucleotide, suggesting that the Pyr <> Pyr flips out of the helix to fit into this hole, and that electron transfer between the flavin and the Pyr <> Pyr occurs over van der Waals contact distance." @default.
- W2051248004 created "2016-06-24" @default.
- W2051248004 creator A5016678671 @default.
- W2051248004 creator A5033642634 @default.
- W2051248004 creator A5052054202 @default.
- W2051248004 creator A5058382490 @default.
- W2051248004 date "1995-06-30" @default.
- W2051248004 modified "2023-10-18" @default.
- W2051248004 title "Crystal Structure of DNA Photolyase from <i>Escherichia coli</i>" @default.
- W2051248004 cites W1483750611 @default.
- W2051248004 cites W1485160972 @default.
- W2051248004 cites W1487863910 @default.
- W2051248004 cites W1506226772 @default.
- W2051248004 cites W1526151739 @default.
- W2051248004 cites W1529637757 @default.
- W2051248004 cites W1531163975 @default.
- W2051248004 cites W1543616404 @default.
- W2051248004 cites W1557525759 @default.
- W2051248004 cites W1585189722 @default.
- W2051248004 cites W1596253765 @default.
- W2051248004 cites W1672031277 @default.
- W2051248004 cites W1875021313 @default.
- W2051248004 cites W1964702126 @default.
- W2051248004 cites W1966041739 @default.
- W2051248004 cites W1969719374 @default.
- W2051248004 cites W1969872559 @default.
- W2051248004 cites W1970109662 @default.
- W2051248004 cites W1971650423 @default.
- W2051248004 cites W1976987540 @default.
- W2051248004 cites W1981852826 @default.
- W2051248004 cites W1982630774 @default.
- W2051248004 cites W1984743062 @default.
- W2051248004 cites W1984999559 @default.
- W2051248004 cites W1986191025 @default.
- W2051248004 cites W1995296611 @default.
- W2051248004 cites W1996607909 @default.
- W2051248004 cites W1996770976 @default.
- W2051248004 cites W1997672520 @default.
- W2051248004 cites W2000468790 @default.
- W2051248004 cites W2002957935 @default.
- W2051248004 cites W2006168594 @default.
- W2051248004 cites W2008773618 @default.
- W2051248004 cites W2013706403 @default.
- W2051248004 cites W2019860157 @default.
- W2051248004 cites W2020493425 @default.
- W2051248004 cites W2021012879 @default.
- W2051248004 cites W2021294566 @default.
- W2051248004 cites W2022359686 @default.
- W2051248004 cites W2022996288 @default.
- W2051248004 cites W2026813999 @default.
- W2051248004 cites W2028231353 @default.
- W2051248004 cites W2028866824 @default.
- W2051248004 cites W2041642148 @default.
- W2051248004 cites W2042066020 @default.
- W2051248004 cites W2042681066 @default.
- W2051248004 cites W204889168 @default.
- W2051248004 cites W2049242791 @default.
- W2051248004 cites W2049893474 @default.
- W2051248004 cites W2052292529 @default.
- W2051248004 cites W2053164365 @default.
- W2051248004 cites W2061243266 @default.
- W2051248004 cites W2063992648 @default.
- W2051248004 cites W2064938462 @default.
- W2051248004 cites W2065355068 @default.
- W2051248004 cites W2067630039 @default.
- W2051248004 cites W2076849893 @default.
- W2051248004 cites W2077890483 @default.
- W2051248004 cites W2081644575 @default.
- W2051248004 cites W2081905161 @default.
- W2051248004 cites W2089068314 @default.
- W2051248004 cites W2090567656 @default.
- W2051248004 cites W2091582757 @default.
- W2051248004 cites W2094153353 @default.
- W2051248004 cites W2104021409 @default.
- W2051248004 cites W2104646138 @default.
- W2051248004 cites W2109494314 @default.
- W2051248004 cites W2113391614 @default.
- W2051248004 cites W2125099341 @default.
- W2051248004 cites W2150482536 @default.
- W2051248004 cites W2157147573 @default.
- W2051248004 cites W2161743998 @default.
- W2051248004 cites W2167373328 @default.
- W2051248004 cites W2180262932 @default.
- W2051248004 cites W2253362361 @default.
- W2051248004 doi "https://doi.org/10.1126/science.7604260" @default.
- W2051248004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7604260" @default.
- W2051248004 hasPublicationYear "1995" @default.
- W2051248004 type Work @default.
- W2051248004 sameAs 2051248004 @default.
- W2051248004 citedByCount "499" @default.
- W2051248004 countsByYear W20512480042012 @default.
- W2051248004 countsByYear W20512480042013 @default.
- W2051248004 countsByYear W20512480042014 @default.
- W2051248004 countsByYear W20512480042015 @default.
- W2051248004 countsByYear W20512480042016 @default.
- W2051248004 countsByYear W20512480042017 @default.
- W2051248004 countsByYear W20512480042018 @default.
- W2051248004 countsByYear W20512480042019 @default.