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• W2051249253 abstract "phobic residues for achieving higher transfection efficiency. 5 Based on these results, we introduce a systematic PAMAM modifying methods for enhancing transfection efficiency as well as maintaining low cytotoxicity. Generally PAMAM dendrimer is synthesized by repeated Michael addition and amidation from ammonia or ethylenediamime core. 1 Hydrophobic PAMAM derivatives with multivalent cationic residues can be obtained by the same synthetic method from a cholesterol core (Scheme 1). Briefly, the cholesteryl chloroformate was treated with excess ethylenediamine to prepare EDA-Chol (ethylenediaminecholesterol). PAM-Chol (polyamidoamine-cholesterol, generation 0.5) was obtained by Michael addition of the primary amine of ethylenediamine to double bonds of two methyl acrylate molecules. The resulting two ester groups of PAMChol (generation 0.5) were attacked by ethylenediamine to produce PAM-Chol (generation 1). Similarly, PAM-Chol (generation 2) was obtained by the same repeated treatment of PAM-Chol (generation 1) with methyl acrylate and ethylenediamine. To avoid side reaction and to obtain a perfect dendritic lipid, we have used excess methyl acrylate and ethylenediamine in each step. Here, we synthesized novel dendritic cationic lipids based on a hydrophobic cholesterol core and performed characterization for gene delivery systems. Finally, their structure-transfection efficiency relationship was investigated. Experimental Section Materials. Ethylenediamine, cholesteryl chloroformate, MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide), and methyl acrylate were purchased from SigmaAldrich (St. Louis, MO). 1,2-Dioleoyl-sn-glycero-3-phos" @default.
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• W2051249253 date "2012-04-20" @default.
• W2051249253 modified "2023-09-25" @default.
• W2051249253 title "Synthesis, Characterization and Application of Dendritic Lipids for Gene Delivery" @default.
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• W2051249253 doi "https://doi.org/10.5012/bkcs.2012.33.4.1353" @default.
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