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- W2051249711 abstract "Reactive oxygen species can enhance B cell antigen receptor (BCR) signaling strength. Dyer and colleagues show that the voltage-gated proton channel HVCN1 associates with BCRs and contributes to BCR signaling via the generation of reactive oxygen species. Voltage-gated proton currents regulate generation of reactive oxygen species (ROS) in phagocytic cells. In B cells, stimulation of the B cell antigen receptor (BCR) results in the production of ROS that participate in B cell activation, but the involvement of proton channels is unknown. We report here that the voltage-gated proton channel HVCN1 associated with the BCR complex and was internalized together with the BCR after activation. BCR-induced generation of ROS was lower in HVCN1-deficient B cells, which resulted in attenuated BCR signaling via impaired BCR-dependent oxidation of the tyrosine phosphatase SHP-1. This resulted in less activation of the kinases Syk and Akt, impaired mitochondrial respiration and glycolysis and diminished antibody responses in vivo. Our findings identify unanticipated functions for proton channels in B cells and demonstrate the importance of ROS in BCR signaling and downstream metabolism." @default.
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- W2051249711 date "2010-02-07" @default.
- W2051249711 modified "2023-10-14" @default.
- W2051249711 title "HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species" @default.
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- W2051249711 doi "https://doi.org/10.1038/ni.1843" @default.
- W2051249711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3030552" @default.
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