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• W2051250763 abstract "By means of two monoclonal antibodies specific for heparan sulfate (HS)-related epitopes, one (10E4) against native HS chains and one (3G10) against desaturated uronates, a highly regional and differential distribution of these two epitopes have been observed in the adult rat brain. The 10E4 epitope immunoreactivity (IR) is mainly found in the substantia nigra, the red nucleus and the subgranular zone of the dentate gyrus, while the 3G10 epitope IR is mainly found in the CA2 area of the hippocampal formation and the pyramidal cells in the layer V of the frontoparietal cortex. The codistribution of boty types of IRs with basic fibroblast growth factor (bFGF, FGF-2) in neurons and astroglia supports the notion that heparan sulfate proteoglycans (HSPG) in the extracellular matrix may serve as a site for storage of bFGF and assist in the bFGF-induced activation of the high-affinity FGF receptors linked to astroglia and neurons in these discrete areas." @default.
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• W2051250763 date "1994-02-01" @default.
• W2051250763 modified "2023-10-02" @default.
• W2051250763 title "On the regional distribution of heparan sulfate proteoglycan immunoreactivity in the rat brain" @default.
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• W2051250763 doi "https://doi.org/10.1016/0006-8993(94)90187-2" @default.
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