FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051250936> ?p ?o ?g. }

• W2051250936 endingPage "451" @default.
• W2051250936 startingPage "441" @default.
• W2051250936 abstract "Protein aggregation is a pathologic hallmark of familial amyotrophic lateral sclerosis caused by mutations in the Cu, Zn superoxide dismutase gene. Although SOD1-positive aggregates can be cleared by proteasomes, aggregates have been hypothesized to interfere with proteasome activity, leading to a vicious cycle that further enhances aggregate accumulation. To address this issue, we measured proteasome activity in transgenic mice expressing a G93A SOD1 mutation. We find that proteasome activity is induced in the spinal cord of such mice compared to controls but is not altered in uninvolved organs such as liver or spleen. This induction within spinal cord is not related to an overall increase in the total number of proteasome subunits, as evidenced by the steady expression levels of constitutive α7 and β5 subunits. In contrast, we found a marked increase of inducible beta proteasome subunits, LMP2, MECL-1 and LMP7. This induction of immunoproteasome subunits does not occur in all spinal cord cell types but appears limited to astrocytes and microglia. The induction of immunoproteasome subunits in G93A spinal cord organotypic slices treated with TNF-α and interferon-γ suggest that certain cytokines may mediate such responses in vivo. Our results indicate that there is an overall increase in proteasome function in the spinal cords of G93A SOD1 mice that correlates with an induction of immunoproteasomes subunits and a shift toward immunoproteasome composition. These results suggest that increased, rather than decreased, proteasome function is a response of certain cell types to mutant SOD1-induced disease within spinal cord." @default.
• W2051250936 created "2016-06-24" @default.
• W2051250936 creator A5045805842 @default.
• W2051250936 creator A5089263791 @default.
• W2051250936 date "2005-12-01" @default.
• W2051250936 modified "2023-09-23" @default.
• W2051250936 title "Non-neuronal induction of immunoproteasome subunits in an ALS model: Possible mediation by cytokines" @default.
• W2051250936 cites W1481321944 @default.
• W2051250936 cites W1512307340 @default.
• W2051250936 cites W1525022089 @default.
• W2051250936 cites W1529384308 @default.
• W2051250936 cites W1542217606 @default.
• W2051250936 cites W1552448470 @default.
• W2051250936 cites W1596334254 @default.
• W2051250936 cites W1966398941 @default.
• W2051250936 cites W1974359257 @default.
• W2051250936 cites W1974809155 @default.
• W2051250936 cites W1980378067 @default.
• W2051250936 cites W1987050708 @default.
• W2051250936 cites W1996350422 @default.
• W2051250936 cites W1997369314 @default.
• W2051250936 cites W1999814371 @default.
• W2051250936 cites W2004837759 @default.
• W2051250936 cites W2006388578 @default.
• W2051250936 cites W2012851706 @default.
• W2051250936 cites W2013135033 @default.
• W2051250936 cites W2022367303 @default.
• W2051250936 cites W2029807159 @default.
• W2051250936 cites W2032706712 @default.
• W2051250936 cites W2040363409 @default.
• W2051250936 cites W2040621074 @default.
• W2051250936 cites W2047532953 @default.
• W2051250936 cites W2052238208 @default.
• W2051250936 cites W2053604048 @default.
• W2051250936 cites W2054659274 @default.
• W2051250936 cites W2059248106 @default.
• W2051250936 cites W2063956237 @default.
• W2051250936 cites W2066013797 @default.
• W2051250936 cites W2082522376 @default.
• W2051250936 cites W2096386031 @default.
• W2051250936 cites W2099040799 @default.
• W2051250936 cites W2102683915 @default.
• W2051250936 cites W2106906885 @default.
• W2051250936 cites W2107198699 @default.
• W2051250936 cites W2107768418 @default.
• W2051250936 cites W2110580010 @default.
• W2051250936 cites W2124084307 @default.
• W2051250936 cites W2130435783 @default.
• W2051250936 cites W2135522980 @default.
• W2051250936 cites W2150128864 @default.
• W2051250936 cites W2154295112 @default.
• W2051250936 cites W2164710551 @default.
• W2051250936 cites W2346624188 @default.
• W2051250936 cites W2404609572 @default.
• W2051250936 cites W4248797315 @default.
• W2051250936 cites W4295887104 @default.
• W2051250936 doi "https://doi.org/10.1016/j.expneurol.2005.08.027" @default.
• W2051250936 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16242125" @default.
• W2051250936 hasPublicationYear "2005" @default.
• W2051250936 type Work @default.
• W2051250936 sameAs 2051250936 @default.
• W2051250936 citedByCount "59" @default.
• W2051250936 countsByYear W20512509362012 @default.
• W2051250936 countsByYear W20512509362013 @default.
• W2051250936 countsByYear W20512509362014 @default.
• W2051250936 countsByYear W20512509362015 @default.
• W2051250936 countsByYear W20512509362016 @default.
• W2051250936 countsByYear W20512509362017 @default.
• W2051250936 countsByYear W20512509362018 @default.
• W2051250936 countsByYear W20512509362019 @default.
• W2051250936 countsByYear W20512509362020 @default.
• W2051250936 countsByYear W20512509362021 @default.
• W2051250936 crossrefType "journal-article" @default.
• W2051250936 hasAuthorship W2051250936A5045805842 @default.
• W2051250936 hasAuthorship W2051250936A5089263791 @default.
• W2051250936 hasConcept C134018914 @default.
• W2051250936 hasConcept C169760540 @default.
• W2051250936 hasConcept C185592680 @default.
• W2051250936 hasConcept C203014093 @default.
• W2051250936 hasConcept C27740335 @default.
• W2051250936 hasConcept C2775838275 @default.
• W2051250936 hasConcept C2776151105 @default.
• W2051250936 hasConcept C2776914184 @default.
• W2051250936 hasConcept C2777615887 @default.
• W2051250936 hasConcept C2778367456 @default.
• W2051250936 hasConcept C2779830541 @default.
• W2051250936 hasConcept C2780775167 @default.
• W2051250936 hasConcept C86803240 @default.
• W2051250936 hasConcept C95444343 @default.
• W2051250936 hasConceptScore W2051250936C134018914 @default.
• W2051250936 hasConceptScore W2051250936C169760540 @default.
• W2051250936 hasConceptScore W2051250936C185592680 @default.
• W2051250936 hasConceptScore W2051250936C203014093 @default.
• W2051250936 hasConceptScore W2051250936C27740335 @default.
• W2051250936 hasConceptScore W2051250936C2775838275 @default.
• W2051250936 hasConceptScore W2051250936C2776151105 @default.
• W2051250936 hasConceptScore W2051250936C2776914184 @default.
• W2051250936 hasConceptScore W2051250936C2777615887 @default.

• next