Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051251551> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2051251551 endingPage "34A" @default.
- W2051251551 startingPage "34A" @default.
- W2051251551 abstract "In an animal model of hyperphenylalaninemia PHE was measurable by MRS in the brain in vivo. Blood and brain concentrations were not correlated (Avison et al 1990, Pediatr Res). We measured brain PHE in 4 early treated adult PKU patients (type I) during an oral load with l-PHE using localized MRS (1.5 T, standard head or surface coil, double echo localisation sequence, TE 20 ms). The PHE peak was identified at 7.4 ppm. in all patients calculating difference spectra (baseline spectra of 8 healthy subjects). PHE quantification was accomplished using the unsuppressed water signal as internal standard (Kreis et al 1993, J Magn Reson B). Blood PHE steaply increased from 981 (696 -1158) uMol/l preload to maximum within 2 h after load. After 5 h (1713 (1423-1913) uMol/l) PHE was stable, after 20 h (1581 (1440 - 1653) uMol/l PHE levels slowly decreased. Increase of brain PHE (preload 230 (80 - 340 uMol/l) was much slower and less steap and continued from 5 h (290 (260 - 330) uMol/l) to 20 h (340 (240 - 490 uMol) postload. Individual blood/brain ratios varied from 2.73 - 5.43. Using MRS to measure PHE in the brain (and thus in the affected compartment) and its dynamics of influx through the blood-brain barrier it should become possible to determine the interindividually different risk in developing brain damage on a more valid basis.(Grant DFG PH96/3-1)." @default.
- W2051251551 created "2016-06-24" @default.
- W2051251551 creator A5022635187 @default.
- W2051251551 creator A5025826885 @default.
- W2051251551 creator A5041784826 @default.
- W2051251551 creator A5053958622 @default.
- W2051251551 creator A5055218218 @default.
- W2051251551 creator A5061413553 @default.
- W2051251551 date "1994-07-01" @default.
- W2051251551 modified "2023-09-26" @default.
- W2051251551 title "192 CEREBRAL PHENYLALANINE (PHE) CONCENTRATIONS IN PATIENTS WITHI (PHENYLKETONURIA (PKU) DETERMINED IN VIVO BY 1H MAGNETIC: RESONANCE SPECTROSCOPY (MRS)" @default.
- W2051251551 doi "https://doi.org/10.1203/00006450-199407000-00192" @default.
- W2051251551 hasPublicationYear "1994" @default.
- W2051251551 type Work @default.
- W2051251551 sameAs 2051251551 @default.
- W2051251551 citedByCount "0" @default.
- W2051251551 crossrefType "journal-article" @default.
- W2051251551 hasAuthorship W2051251551A5022635187 @default.
- W2051251551 hasAuthorship W2051251551A5025826885 @default.
- W2051251551 hasAuthorship W2051251551A5041784826 @default.
- W2051251551 hasAuthorship W2051251551A5053958622 @default.
- W2051251551 hasAuthorship W2051251551A5055218218 @default.
- W2051251551 hasAuthorship W2051251551A5061413553 @default.
- W2051251551 hasBestOaLocation W20512515511 @default.
- W2051251551 hasConcept C121332964 @default.
- W2051251551 hasConcept C126322002 @default.
- W2051251551 hasConcept C134018914 @default.
- W2051251551 hasConcept C150903083 @default.
- W2051251551 hasConcept C178853913 @default.
- W2051251551 hasConcept C185592680 @default.
- W2051251551 hasConcept C207001950 @default.
- W2051251551 hasConcept C2777431362 @default.
- W2051251551 hasConcept C2780968477 @default.
- W2051251551 hasConcept C2908963387 @default.
- W2051251551 hasConcept C46141821 @default.
- W2051251551 hasConcept C48277249 @default.
- W2051251551 hasConcept C515207424 @default.
- W2051251551 hasConcept C55493867 @default.
- W2051251551 hasConcept C71924100 @default.
- W2051251551 hasConcept C86803240 @default.
- W2051251551 hasConceptScore W2051251551C121332964 @default.
- W2051251551 hasConceptScore W2051251551C126322002 @default.
- W2051251551 hasConceptScore W2051251551C134018914 @default.
- W2051251551 hasConceptScore W2051251551C150903083 @default.
- W2051251551 hasConceptScore W2051251551C178853913 @default.
- W2051251551 hasConceptScore W2051251551C185592680 @default.
- W2051251551 hasConceptScore W2051251551C207001950 @default.
- W2051251551 hasConceptScore W2051251551C2777431362 @default.
- W2051251551 hasConceptScore W2051251551C2780968477 @default.
- W2051251551 hasConceptScore W2051251551C2908963387 @default.
- W2051251551 hasConceptScore W2051251551C46141821 @default.
- W2051251551 hasConceptScore W2051251551C48277249 @default.
- W2051251551 hasConceptScore W2051251551C515207424 @default.
- W2051251551 hasConceptScore W2051251551C55493867 @default.
- W2051251551 hasConceptScore W2051251551C71924100 @default.
- W2051251551 hasConceptScore W2051251551C86803240 @default.
- W2051251551 hasIssue "1" @default.
- W2051251551 hasLocation W20512515511 @default.
- W2051251551 hasOpenAccess W2051251551 @default.
- W2051251551 hasPrimaryLocation W20512515511 @default.
- W2051251551 hasRelatedWork W1978484407 @default.
- W2051251551 hasRelatedWork W2009363429 @default.
- W2051251551 hasRelatedWork W2051251551 @default.
- W2051251551 hasRelatedWork W2089659821 @default.
- W2051251551 hasRelatedWork W2110853830 @default.
- W2051251551 hasRelatedWork W2136382339 @default.
- W2051251551 hasRelatedWork W2157591129 @default.
- W2051251551 hasRelatedWork W2410844210 @default.
- W2051251551 hasRelatedWork W2419465245 @default.
- W2051251551 hasRelatedWork W2748952813 @default.
- W2051251551 hasVolume "36" @default.
- W2051251551 isParatext "false" @default.
- W2051251551 isRetracted "false" @default.
- W2051251551 magId "2051251551" @default.
- W2051251551 workType "article" @default.