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- W2051255419 abstract "Lymph nodes from 22 cases of non-Hodgkin's lymphoma were analyzed for the presence of intracytoplasmic immunoglobulin and mononuclear cell markers. Study of neoplastic cells failed to demonstrate the presence of nonspecific esterases, indicating that these malignant cells were not of macrophage origin. In two cases neoplastic cells formed nonimmune rosettes with sheep erythrocytes, suggesting a T cell lineage for these lymphoproliferative disorders. Five patterns of immunoglobulin distribution were observed: (1) surface membrane immunoglobulin and intracytoplasmic immunoglobulin were present with identical heavy chains (four cases), (2) surface membrane immunoglobulin was detected and intracytoplasmic immunoglobulin was not found (six cases), (3) intracytoplasmic immunoglobulin was present with little or no surface membrane immunoglobulin detectable (four cases), (4) neither could be detected (four cases), and (5) both were detected but the immunoglobulin heavy chains were different (four cases). The identification of intracytoplasmic immunoglobulin is complementary to the detection of surface membrane immunoglobulin in the determination of B cell lineage of lymphomatous cells. The different patterns of cellular and membrane immunoglobulin staining may represent different states of B cell maturation." @default.
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- W2051255419 date "1978-05-01" @default.
- W2051255419 modified "2023-09-27" @default.
- W2051255419 title "Detection of intracellular and cell surface immunoglobulin in non-Hodgkin's lymphoma" @default.
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- W2051255419 doi "https://doi.org/10.1016/s0046-8177(78)80086-0" @default.
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