FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051255960> ?p ?o ?g. }

• W2051255960 endingPage "365" @default.
• W2051255960 startingPage "359" @default.
• W2051255960 abstract "Ductal adenocarcinoma of the prostate is an unusual subtype that may be associated with a more aggressive clinical course, and is less responsive to conventional therapies than the more common prostatic acinar adenocarcinoma. However, given its frequent association with an acinar component at prostatectomy, some have challenged the concept of prostatic ductal adenocarcinoma as a distinct clinicopathologic entity. We studied the occurrence of the TMPRSS2-ERG gene fusion, in 40 surgically resected ductal adenocarcinoma cases, and in their associated acinar component using fluorescence in situ hybridization. A group of 38 ‘pure’ acinar adenocarcinoma cases matched with the ductal adenocarcinoma group for pathological grade and stage was studied as a control. Compared with the matched acinar adenocarcinoma cases, the TMPRSS2-ERG gene fusion was significantly less frequently observed in ductal adenocarcinoma (45 vs 11% of cases, P=0.002, Fisher's exact test). Here, of the ductal adenocarcinoma cases with the gene fusion, 75% were fused through deletion, and the remaining case was fused through translocation. The TMPRSS2-ERG gene fusion was also rare in the acinar component of mixed ductal–acinar tumors when compared with the pure acinar adenocarcinoma controls (5 vs 45%, P=0.001, Fisher's exact test). In 95% of the ductal adenocarcinoma cases in which a concurrent acinar component was analyzed, there was concordance for presence/absence of the TMPRSS2-ERG gene fusion between the different histologic subtypes. In the control group of pure acinar adenocarcinoma cases, 59% were fused through deletion and 41% were fused through translocation. The presence of the TMPRSS2-ERG gene fusion in some cases of prostatic ductal adenocarcinoma supports the concept that ductal adenocarcinoma and acinar adenocarcinoma may be related genetically. However, the significantly lower rate of the gene fusion in pure ductal adenocarcinoma cases underscores the fact that genetic and biologic differences exist between these two tumors that may be important for future therapeutic strategies." @default.
• W2051255960 created "2016-06-24" @default.
• W2051255960 creator A5008552473 @default.
• W2051255960 creator A5013629270 @default.
• W2051255960 creator A5024041740 @default.
• W2051255960 creator A5028865365 @default.
• W2051255960 creator A5039913775 @default.
• W2051255960 creator A5046571335 @default.
• W2051255960 creator A5049793329 @default.
• W2051255960 creator A5056103345 @default.
• W2051255960 creator A5062227791 @default.
• W2051255960 creator A5064618296 @default.
• W2051255960 date "2009-03-01" @default.
• W2051255960 modified "2023-10-18" @default.
• W2051255960 title "TMPRSS2-ERG gene fusions are infrequent in prostatic ductal adenocarcinomas" @default.
• W2051255960 cites W1976239387 @default.
• W2051255960 cites W1976677295 @default.
• W2051255960 cites W1977038405 @default.
• W2051255960 cites W1986927943 @default.
• W2051255960 cites W1992079095 @default.
• W2051255960 cites W1996447938 @default.
• W2051255960 cites W2015437876 @default.
• W2051255960 cites W2019288266 @default.
• W2051255960 cites W2032704701 @default.
• W2051255960 cites W2042302891 @default.
• W2051255960 cites W2057194313 @default.
• W2051255960 cites W2061891797 @default.
• W2051255960 cites W2064967695 @default.
• W2051255960 cites W2082462837 @default.
• W2051255960 cites W2085115464 @default.
• W2051255960 cites W2088871691 @default.
• W2051255960 cites W2095529727 @default.
• W2051255960 cites W2096800294 @default.
• W2051255960 cites W2121158863 @default.
• W2051255960 cites W2146294552 @default.
• W2051255960 cites W2147660153 @default.
• W2051255960 cites W2286963667 @default.
• W2051255960 doi "https://doi.org/10.1038/modpathol.2008.236" @default.
• W2051255960 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3484370" @default.
• W2051255960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19789567" @default.
• W2051255960 hasPublicationYear "2009" @default.
• W2051255960 type Work @default.
• W2051255960 sameAs 2051255960 @default.
• W2051255960 citedByCount "48" @default.
• W2051255960 countsByYear W20512559602012 @default.
• W2051255960 countsByYear W20512559602013 @default.
• W2051255960 countsByYear W20512559602015 @default.
• W2051255960 countsByYear W20512559602016 @default.
• W2051255960 countsByYear W20512559602017 @default.
• W2051255960 countsByYear W20512559602018 @default.
• W2051255960 countsByYear W20512559602019 @default.
• W2051255960 countsByYear W20512559602020 @default.
• W2051255960 countsByYear W20512559602021 @default.
• W2051255960 countsByYear W20512559602022 @default.
• W2051255960 countsByYear W20512559602023 @default.
• W2051255960 crossrefType "journal-article" @default.
• W2051255960 hasAuthorship W2051255960A5008552473 @default.
• W2051255960 hasAuthorship W2051255960A5013629270 @default.
• W2051255960 hasAuthorship W2051255960A5024041740 @default.
• W2051255960 hasAuthorship W2051255960A5028865365 @default.
• W2051255960 hasAuthorship W2051255960A5039913775 @default.
• W2051255960 hasAuthorship W2051255960A5046571335 @default.
• W2051255960 hasAuthorship W2051255960A5049793329 @default.
• W2051255960 hasAuthorship W2051255960A5056103345 @default.
• W2051255960 hasAuthorship W2051255960A5062227791 @default.
• W2051255960 hasAuthorship W2051255960A5064618296 @default.
• W2051255960 hasBestOaLocation W20512559601 @default.
• W2051255960 hasConcept C104317684 @default.
• W2051255960 hasConcept C111829193 @default.
• W2051255960 hasConcept C121608353 @default.
• W2051255960 hasConcept C126322002 @default.
• W2051255960 hasConcept C142724271 @default.
• W2051255960 hasConcept C2776235491 @default.
• W2051255960 hasConcept C2778042024 @default.
• W2051255960 hasConcept C2779134260 @default.
• W2051255960 hasConcept C2781182431 @default.
• W2051255960 hasConcept C3008058167 @default.
• W2051255960 hasConcept C502942594 @default.
• W2051255960 hasConcept C524204448 @default.
• W2051255960 hasConcept C55493867 @default.
• W2051255960 hasConcept C71924100 @default.
• W2051255960 hasConcept C86803240 @default.
• W2051255960 hasConceptScore W2051255960C104317684 @default.
• W2051255960 hasConceptScore W2051255960C111829193 @default.
• W2051255960 hasConceptScore W2051255960C121608353 @default.
• W2051255960 hasConceptScore W2051255960C126322002 @default.
• W2051255960 hasConceptScore W2051255960C142724271 @default.
• W2051255960 hasConceptScore W2051255960C2776235491 @default.
• W2051255960 hasConceptScore W2051255960C2778042024 @default.
• W2051255960 hasConceptScore W2051255960C2779134260 @default.
• W2051255960 hasConceptScore W2051255960C2781182431 @default.
• W2051255960 hasConceptScore W2051255960C3008058167 @default.
• W2051255960 hasConceptScore W2051255960C502942594 @default.
• W2051255960 hasConceptScore W2051255960C524204448 @default.
• W2051255960 hasConceptScore W2051255960C55493867 @default.
• W2051255960 hasConceptScore W2051255960C71924100 @default.
• W2051255960 hasConceptScore W2051255960C86803240 @default.
• W2051255960 hasIssue "3" @default.

• next