FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051256200> ?p ?o ?g. }

• W2051256200 endingPage "290" @default.
• W2051256200 startingPage "281" @default.
• W2051256200 abstract "The potent dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is known to produce hydroxyl radicals (OH) in vitro and in vivo. Salicylate (SA) can hydroxylate itself to form 2,3- and 2,5-dihydroxybenzoic acid (DHBA) by utilizing OH. In the present study we investigated the OH scavenging action and neuroprotective effects, if any, of SA in mice treated with MPTP (30 mg/kg i.p. twice, 16 h apart). MPTP treatment resulted in in vivo generation of OH and nigral neuronal insult as evidenced by dopamine depletion in nucleus caudatus putamen (NCP). This also caused significant decrease in glutathione in substantia nigra (SN) and NCP. SA administration alone in mice did not affect total monoamine oxidase (MAO) or MAO-B activities of the mitochondrial fraction or the crude enzyme preparation from SN or NCP. Pre-treatment of these animals with SA (25–100 mg/kg, i.p.) resulted in dose-dependent production of 2,3- and 2,5-DHBA in NCP. SA administration prior to or following MPTP blocked the neurotoxin-induced behavioural dysfunction as well as glutathione and dopamine depletion on the 7th day indicating its potent neuroprotective action. The present study suggests that SA acts as a free radical scavenger in the brain and indicates its strength as a valuable neuroprotectant." @default.
• W2051256200 created "2016-06-24" @default.
• W2051256200 creator A5015079783 @default.
• W2051256200 creator A5034319410 @default.
• W2051256200 creator A5039743902 @default.
• W2051256200 date "2000-05-01" @default.
• W2051256200 modified "2023-09-27" @default.
• W2051256200 title "Neuroprotection by sodium salicylate against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity" @default.
• W2051256200 cites W1512211793 @default.
• W2051256200 cites W1530821577 @default.
• W2051256200 cites W1563718043 @default.
• W2051256200 cites W1775749144 @default.
• W2051256200 cites W1809574325 @default.
• W2051256200 cites W1825467595 @default.
• W2051256200 cites W1870315080 @default.
• W2051256200 cites W1970921883 @default.
• W2051256200 cites W1974210616 @default.
• W2051256200 cites W1977125253 @default.
• W2051256200 cites W1983221766 @default.
• W2051256200 cites W1983695554 @default.
• W2051256200 cites W1984061110 @default.
• W2051256200 cites W1985285096 @default.
• W2051256200 cites W1985970535 @default.
• W2051256200 cites W1991743392 @default.
• W2051256200 cites W1992459404 @default.
• W2051256200 cites W1999220416 @default.
• W2051256200 cites W2001900968 @default.
• W2051256200 cites W2004611188 @default.
• W2051256200 cites W2005102504 @default.
• W2051256200 cites W2011860530 @default.
• W2051256200 cites W2012609836 @default.
• W2051256200 cites W2014125820 @default.
• W2051256200 cites W2014703027 @default.
• W2051256200 cites W2016336099 @default.
• W2051256200 cites W2017577705 @default.
• W2051256200 cites W2021390693 @default.
• W2051256200 cites W2029682063 @default.
• W2051256200 cites W2030997673 @default.
• W2051256200 cites W2037730680 @default.
• W2051256200 cites W2041734419 @default.
• W2051256200 cites W2044158166 @default.
• W2051256200 cites W2047599104 @default.
• W2051256200 cites W2055377729 @default.
• W2051256200 cites W2057821937 @default.
• W2051256200 cites W2058760852 @default.
• W2051256200 cites W2063500181 @default.
• W2051256200 cites W2073017049 @default.
• W2051256200 cites W2079849987 @default.
• W2051256200 cites W2081803698 @default.
• W2051256200 cites W2084771666 @default.
• W2051256200 cites W2088624681 @default.
• W2051256200 cites W2089742974 @default.
• W2051256200 cites W2094844228 @default.
• W2051256200 cites W2116619064 @default.
• W2051256200 cites W2129867203 @default.
• W2051256200 cites W2144437860 @default.
• W2051256200 cites W4322703223 @default.
• W2051256200 doi "https://doi.org/10.1016/s0006-8993(00)02189-2" @default.
• W2051256200 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10802035" @default.
• W2051256200 hasPublicationYear "2000" @default.
• W2051256200 type Work @default.
• W2051256200 sameAs 2051256200 @default.
• W2051256200 citedByCount "111" @default.
• W2051256200 countsByYear W20512562002012 @default.
• W2051256200 countsByYear W20512562002013 @default.
• W2051256200 countsByYear W20512562002014 @default.
• W2051256200 countsByYear W20512562002015 @default.
• W2051256200 countsByYear W20512562002016 @default.
• W2051256200 countsByYear W20512562002017 @default.
• W2051256200 countsByYear W20512562002018 @default.
• W2051256200 countsByYear W20512562002019 @default.
• W2051256200 countsByYear W20512562002021 @default.
• W2051256200 countsByYear W20512562002022 @default.
• W2051256200 countsByYear W20512562002023 @default.
• W2051256200 crossrefType "journal-article" @default.
• W2051256200 hasAuthorship W2051256200A5015079783 @default.
• W2051256200 hasAuthorship W2051256200A5034319410 @default.
• W2051256200 hasAuthorship W2051256200A5039743902 @default.
• W2051256200 hasConcept C134018914 @default.
• W2051256200 hasConcept C137183658 @default.
• W2051256200 hasConcept C150903083 @default.
• W2051256200 hasConcept C178790620 @default.
• W2051256200 hasConcept C181199279 @default.
• W2051256200 hasConcept C185592680 @default.
• W2051256200 hasConcept C207001950 @default.
• W2051256200 hasConcept C25498285 @default.
• W2051256200 hasConcept C2776024655 @default.
• W2051256200 hasConcept C2778674702 @default.
• W2051256200 hasConcept C2779134981 @default.
• W2051256200 hasConcept C2779491297 @default.
• W2051256200 hasConcept C2780358027 @default.
• W2051256200 hasConcept C2780938664 @default.
• W2051256200 hasConcept C29730261 @default.
• W2051256200 hasConcept C513476851 @default.
• W2051256200 hasConcept C538909803 @default.
• W2051256200 hasConcept C55493867 @default.
• W2051256200 hasConcept C86803240 @default.
• W2051256200 hasConcept C98274493 @default.

• next