FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051258100> ?p ?o ?g. }

• W2051258100 abstract "The use of caspase inhibitors has revealed the existence of alternative backup cell death programs for apoptosis. The broad-spectrum caspase inhibitor zVAD-fmk modulates the three major types of cell death. Addition of zVAD-fmk blocks apoptotic cell death, sensitizes cells to necrotic cell death, and induces autophagic cell death. Several studies have shown a crucial role for the kinase RIP1 and the adenosine nucleotide translocator (ANT)–cyclophilin D (CypD) complex in necrotic cell death. The underlying mechanism of zVAD-fmk–mediated sensitization to necrotic cell death involves the inhibition of caspase-8–mediated proteolysis of RIP1 and disturbance of the ANT-CypD interaction. RIP1 is also involved in autophagic cell death. Caspase inhibitors and knockdown studies have revealed negative roles for catalase and caspase-8 in autophagic cell death. The positive role of RIP1 and the negative role of caspase-8 in both necrotic and autophagic cell death suggest that the pathways of these two types of cell death are interconnected. Necrotic cell death represents a rapid cellular response involving mitochondrial reactive oxygen species (ROS) production, decreased adenosine triphosphate concentration, and other cellular insults, whereas autophagic cell death first starts as a survival attempt by cleaning up ROS-damaged mitochondria. However, when this process occurs in excess, autophagy itself becomes cytotoxic and eventually leads to autophagic cell death. A better understanding of the molecular mechanisms of these alternative cell death pathways may provide therapeutic tools to combat cell death associated with neurodegenerative diseases, ischemia-reperfusion pathologies, and infectious diseases, and may also facilitate the development of alternative cytotoxic strategies in cancer treatment." @default.
• W2051258100 created "2016-06-24" @default.
• W2051258100 creator A5087011923 @default.
• W2051258100 creator A5089113838 @default.
• W2051258100 creator A5089980453 @default.
• W2051258100 date "2006-10-24" @default.
• W2051258100 modified "2023-10-17" @default.
• W2051258100 title "Caspase Inhibitors Promote Alternative Cell Death Pathways" @default.
• W2051258100 cites W1500106790 @default.
• W2051258100 cites W1523845694 @default.
• W2051258100 cites W1541897964 @default.
• W2051258100 cites W1658228410 @default.
• W2051258100 cites W1967894078 @default.
• W2051258100 cites W1971608015 @default.
• W2051258100 cites W1986168589 @default.
• W2051258100 cites W1986978728 @default.
• W2051258100 cites W1988193713 @default.
• W2051258100 cites W1994874844 @default.
• W2051258100 cites W2008258524 @default.
• W2051258100 cites W2012985988 @default.
• W2051258100 cites W2017855147 @default.
• W2051258100 cites W2026722168 @default.
• W2051258100 cites W2042222447 @default.
• W2051258100 cites W2050518426 @default.
• W2051258100 cites W2051439699 @default.
• W2051258100 cites W2063099262 @default.
• W2051258100 cites W2066255425 @default.
• W2051258100 cites W2067692987 @default.
• W2051258100 cites W2069952533 @default.
• W2051258100 cites W2070885630 @default.
• W2051258100 cites W2074800090 @default.
• W2051258100 cites W2083890417 @default.
• W2051258100 cites W2085459880 @default.
• W2051258100 cites W2089275663 @default.
• W2051258100 cites W2089394364 @default.
• W2051258100 cites W2090684431 @default.
• W2051258100 cites W2094726531 @default.
• W2051258100 cites W2096378217 @default.
• W2051258100 cites W2104205504 @default.
• W2051258100 cites W2114727688 @default.
• W2051258100 cites W2120633856 @default.
• W2051258100 cites W2121082164 @default.
• W2051258100 cites W2130407823 @default.
• W2051258100 cites W2133000461 @default.
• W2051258100 cites W2133169035 @default.
• W2051258100 cites W2144326453 @default.
• W2051258100 cites W2149388384 @default.
• W2051258100 cites W2159882838 @default.
• W2051258100 doi "https://doi.org/10.1126/stke.3582006pe44" @default.
• W2051258100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17062895" @default.
• W2051258100 hasPublicationYear "2006" @default.
• W2051258100 type Work @default.
• W2051258100 sameAs 2051258100 @default.
• W2051258100 citedByCount "176" @default.
• W2051258100 countsByYear W20512581002012 @default.
• W2051258100 countsByYear W20512581002013 @default.
• W2051258100 countsByYear W20512581002014 @default.
• W2051258100 countsByYear W20512581002015 @default.
• W2051258100 countsByYear W20512581002016 @default.
• W2051258100 countsByYear W20512581002017 @default.
• W2051258100 countsByYear W20512581002018 @default.
• W2051258100 countsByYear W20512581002019 @default.
• W2051258100 countsByYear W20512581002020 @default.
• W2051258100 countsByYear W20512581002021 @default.
• W2051258100 countsByYear W20512581002022 @default.
• W2051258100 countsByYear W20512581002023 @default.
• W2051258100 crossrefType "journal-article" @default.
• W2051258100 hasAuthorship W2051258100A5087011923 @default.
• W2051258100 hasAuthorship W2051258100A5089113838 @default.
• W2051258100 hasAuthorship W2051258100A5089980453 @default.
• W2051258100 hasConcept C190283241 @default.
• W2051258100 hasConcept C203522944 @default.
• W2051258100 hasConcept C2776055636 @default.
• W2051258100 hasConcept C31573885 @default.
• W2051258100 hasConcept C55493867 @default.
• W2051258100 hasConcept C86803240 @default.
• W2051258100 hasConcept C94030615 @default.
• W2051258100 hasConcept C95444343 @default.
• W2051258100 hasConcept C98424977 @default.
• W2051258100 hasConceptScore W2051258100C190283241 @default.
• W2051258100 hasConceptScore W2051258100C203522944 @default.
• W2051258100 hasConceptScore W2051258100C2776055636 @default.
• W2051258100 hasConceptScore W2051258100C31573885 @default.
• W2051258100 hasConceptScore W2051258100C55493867 @default.
• W2051258100 hasConceptScore W2051258100C86803240 @default.
• W2051258100 hasConceptScore W2051258100C94030615 @default.
• W2051258100 hasConceptScore W2051258100C95444343 @default.
• W2051258100 hasConceptScore W2051258100C98424977 @default.
• W2051258100 hasIssue "358" @default.
• W2051258100 hasLocation W20512581001 @default.
• W2051258100 hasLocation W20512581002 @default.
• W2051258100 hasOpenAccess W2051258100 @default.
• W2051258100 hasPrimaryLocation W20512581001 @default.
• W2051258100 hasRelatedWork W1482038694 @default.
• W2051258100 hasRelatedWork W1952688415 @default.
• W2051258100 hasRelatedWork W2012224340 @default.
• W2051258100 hasRelatedWork W2055507365 @default.
• W2051258100 hasRelatedWork W2084880710 @default.
• W2051258100 hasRelatedWork W2388475655 @default.
• W2051258100 hasRelatedWork W2621136438 @default.

• next