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• W2051259034 abstract "Microglia, the resident immune cells of the brain, have recently been hypothesized to play a role both in neuronal diseases and age-related neurogenic decline, and are theorized to be modulators of adult neurogenesis. Current methods for the isolation of microglia from cultured primary brain tissue result in relatively poor yield, requiring a large tissue sample or multiple specimens to obtain a sufficient number of microglia for cell and molecular analysis. We report here a method for the repetitive isolation of microglia from established glial monolayer cultures from which it is possible to expand the initial population of microglia roughly 10,000-fold. The expanded population expresses appropriate microglial morphology and phenotype markers, and demonstrates functionally normal phagocytosis, thus providing a high-yield assay for the investigation and analysis of microglia from a single initial dissection of primary tissue. Furthermore, this massive expansion is limited to microglia derived from the subventricular zone as the fold expansion of isolatable microglia was found to be up to 20 times greater than cultures from other brain regions, indicating unique properties for this persistently neurogenic region." @default.
• W2051259034 created "2016-06-24" @default.
• W2051259034 creator A5007369782 @default.
• W2051259034 creator A5051628983 @default.
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• W2051259034 date "2008-12-01" @default.
• W2051259034 modified "2023-09-27" @default.
• W2051259034 title "Subventricular zone microglia possess a unique capacity for massive<i>in vitro</i>expansion" @default.
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• W2051259034 doi "https://doi.org/10.1002/glia.20730" @default.
• W2051259034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4424978" @default.
• W2051259034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18661554" @default.
• W2051259034 hasPublicationYear "2008" @default.
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