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- W2051259253 abstract "Erythropoiesis describes the hematopoietic process of cell proliferation and differentiation that results in the production of mature circulating erythrocytes. Adult humans produce 200 billion erythrocytes daily, and approximately 1 billion iron molecules are incorporated into the hemoglobin contained within each erythrocyte. Thus, iron usage for the hemoglobin production is a primary regulator of plasma iron supply and demand. In many anemias, additional sources of iron from diet and tissue stores are needed to meet the erythroid demand. Among a subset of anemias that arise from ineffective erythropoiesis, iron absorption and accumulation in the tissues increases to levels that are in excess of erythropoiesis demand even in the absence of transfusion. The mechanisms responsible for iron overloading due to ineffective erythropoiesis are not fully understood. Based upon data that is currently available, it is proposed in this review that loading and overloading of iron can be regulated by distinct or combined mechanisms associated with erythropoiesis. The concept of erythroid regulation of iron is broadened to include both physiological and pathological hepcidin suppression in cases of ineffective erythropoiesis." @default.
- W2051259253 created "2016-06-24" @default.
- W2051259253 creator A5025133816 @default.
- W2051259253 creator A5052306699 @default.
- W2051259253 date "2010-01-01" @default.
- W2051259253 modified "2023-09-29" @default.
- W2051259253 title "Iron Loading and Overloading due to Ineffective Erythropoiesis" @default.
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- W2051259253 cites W141072551 @default.
- W2051259253 cites W142784863 @default.
- W2051259253 cites W1514989738 @default.
- W2051259253 cites W1534052611 @default.
- W2051259253 cites W1677338 @default.
- W2051259253 cites W1969627273 @default.
- W2051259253 cites W1973313690 @default.
- W2051259253 cites W1974775992 @default.
- W2051259253 cites W1980042430 @default.
- W2051259253 cites W1981192738 @default.
- W2051259253 cites W1981919419 @default.
- W2051259253 cites W1982570220 @default.
- W2051259253 cites W1983658905 @default.
- W2051259253 cites W1984119913 @default.
- W2051259253 cites W1989196507 @default.
- W2051259253 cites W1991054527 @default.
- W2051259253 cites W1992203007 @default.
- W2051259253 cites W1994678138 @default.
- W2051259253 cites W1995062933 @default.
- W2051259253 cites W1999285447 @default.
- W2051259253 cites W2001293440 @default.
- W2051259253 cites W2004006750 @default.
- W2051259253 cites W2005438156 @default.
- W2051259253 cites W2011629202 @default.
- W2051259253 cites W2015802834 @default.
- W2051259253 cites W2016849042 @default.
- W2051259253 cites W2019305952 @default.
- W2051259253 cites W2022126917 @default.
- W2051259253 cites W2023554312 @default.
- W2051259253 cites W2024706459 @default.
- W2051259253 cites W2025063713 @default.
- W2051259253 cites W2025275264 @default.
- W2051259253 cites W2025812024 @default.
- W2051259253 cites W2029899420 @default.
- W2051259253 cites W2034565548 @default.
- W2051259253 cites W2038220832 @default.
- W2051259253 cites W2042071450 @default.
- W2051259253 cites W2046133662 @default.
- W2051259253 cites W2047720950 @default.
- W2051259253 cites W2050833520 @default.
- W2051259253 cites W2056121022 @default.
- W2051259253 cites W2058411339 @default.
- W2051259253 cites W2063509140 @default.
- W2051259253 cites W2072993305 @default.
- W2051259253 cites W2074040887 @default.
- W2051259253 cites W2075795942 @default.
- W2051259253 cites W2087614483 @default.
- W2051259253 cites W2089333962 @default.
- W2051259253 cites W2090925999 @default.
- W2051259253 cites W2092704973 @default.
- W2051259253 cites W2093027322 @default.
- W2051259253 cites W2095400049 @default.
- W2051259253 cites W2101367930 @default.
- W2051259253 cites W2107423980 @default.
- W2051259253 cites W2112225163 @default.
- W2051259253 cites W2113462770 @default.
- W2051259253 cites W2116374020 @default.
- W2051259253 cites W2116991069 @default.
- W2051259253 cites W2117133328 @default.
- W2051259253 cites W2120269793 @default.
- W2051259253 cites W2121871264 @default.
- W2051259253 cites W2122529586 @default.
- W2051259253 cites W2130190421 @default.
- W2051259253 cites W2163487646 @default.
- W2051259253 cites W2169337490 @default.
- W2051259253 cites W4210960127 @default.
- W2051259253 cites W4211235902 @default.
- W2051259253 cites W4231838548 @default.
- W2051259253 cites W4232187658 @default.
- W2051259253 cites W4234693960 @default.
- W2051259253 cites W4247174101 @default.
- W2051259253 cites W4247184326 @default.
- W2051259253 cites W65838774 @default.
- W2051259253 cites W825230054 @default.
- W2051259253 doi "https://doi.org/10.1155/2010/358283" @default.
- W2051259253 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2868182" @default.
- W2051259253 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20467559" @default.
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