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- W2051259760 abstract "STC-1 cells have been established as an enteroendocrine cell line from the small intestine. By monitoring the level of intracellular Ca2+ using a calcium-imaging technique, cellular responses of intestinal STC-1 cells to compounds of five basic tastants were investigated. Although this cell line was known to respond to bitter compounds, we found that compounds of the other four basic tastants also stimulate STC-1 cells. When solutions containing glutamate, sucrose, HCl, or NaCl were applied, the intracellular Ca2+ concentration in STC-1 cells significantly increased. We thus demonstrated that the gastrointestinal system can sense all five basic taste stimuli, and that STC-1 cells emerge as a new cell model for studying the molecular mechanism of signaling pathways of the five basic tastants." @default.
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- W2051259760 date "2007-12-03" @default.
- W2051259760 modified "2023-09-27" @default.
- W2051259760 title "Intestinal STC-1 cells respond to five basic taste stimuli" @default.
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- W2051259760 doi "https://doi.org/10.1097/wnr.0b013e3282f242d3" @default.
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