FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051259778> ?p ?o ?g. }

• W2051259778 endingPage "409" @default.
• W2051259778 startingPage "397" @default.
• W2051259778 abstract "Protein kinase C (PKC) comprises a family of kinases consisting of nine subspecies that are differentially distributed in the central nervous system. This implies distinct functions. Its involvement is suggested in cellular and molecular mechanisms by which the hippocampus exerts influence on information processing. In this study, it was questioned whether abnormal activity in the neuronal substrate, particularly the hippocampal formation, induced by amygdala kindling indeed impairs spatial memory performance and correlated α, βI/II, and γ PKC subspecies expression. Rats were trained in a spatial discrimination task (SDT) and simultaneously kindled in the amygdala to induce abnormal, epileptiform activity. Control rats were only trained in the holeboard, a “free choice” maze, in which working (WM) and reference memory (RM) were simultaneously examined. Halfway through and at the end of the experiments the influence of kindling and SDT training on the immunoreactivity for PKC subspecies α, βI/II, and γ was evaluated in the hippocampal formation. Kindling resulted in a gradual increase in afterdischarge duration and motor seizure (MS) severity. Repeated SDT training ultimately resulted in an asymptotic level of WM and RM performance. As soon as generalized MSs developed, kindled rats failed to improve RM, whereas WM was not influenced. Compared to untrained rats, in trained controls PKCγ but not PKCαβI/II immunoreactivity was elevated in CA1 pyramidal and dentate gyrus granular cells. Generalized but not partial MSs abolished these alterations in PKCγ immunoreactivity. The present data indicate that repeated training in a SDT affects the expression of PKC subspecies γ but not of α or β in the rat hippocampus. Generalized epileptiform activity impair both acquisition of new spatial RM information and PKCγ expression. It is argued that PKCγ plays a role in cellular mechanisms through which pathological brain activity impairs certain aspects of spatial memory." @default.
• W2051259778 created "2016-06-24" @default.
• W2051259778 creator A5009643915 @default.
• W2051259778 creator A5010268706 @default.
• W2051259778 creator A5015017964 @default.
• W2051259778 creator A5016032221 @default.
• W2051259778 creator A5063259248 @default.
• W2051259778 date "1992-10-04" @default.
• W2051259778 modified "2023-09-24" @default.
• W2051259778 title "Amygdala kindling-induced seizures selectively impair spatial memory. 1. Behavioral characteristics and effects on hippocampal neuronal protein kinase C isoforms" @default.
• W2051259778 cites W102961341 @default.
• W2051259778 cites W116130616 @default.
• W2051259778 cites W129302939 @default.
• W2051259778 cites W1483800737 @default.
• W2051259778 cites W1504073232 @default.
• W2051259778 cites W1516468632 @default.
• W2051259778 cites W1528279723 @default.
• W2051259778 cites W1596920720 @default.
• W2051259778 cites W1650137855 @default.
• W2051259778 cites W1966017723 @default.
• W2051259778 cites W1970917461 @default.
• W2051259778 cites W1975695296 @default.
• W2051259778 cites W1986899276 @default.
• W2051259778 cites W1989719327 @default.
• W2051259778 cites W1990279081 @default.
• W2051259778 cites W1990565557 @default.
• W2051259778 cites W1990622202 @default.
• W2051259778 cites W1994312297 @default.
• W2051259778 cites W1995360961 @default.
• W2051259778 cites W1995779880 @default.
• W2051259778 cites W1997472946 @default.
• W2051259778 cites W2001145840 @default.
• W2051259778 cites W2010176200 @default.
• W2051259778 cites W2014367829 @default.
• W2051259778 cites W2016261700 @default.
• W2051259778 cites W2017169966 @default.
• W2051259778 cites W2021468457 @default.
• W2051259778 cites W2022897328 @default.
• W2051259778 cites W2024300178 @default.
• W2051259778 cites W2028354316 @default.
• W2051259778 cites W2033319161 @default.
• W2051259778 cites W2034318573 @default.
• W2051259778 cites W2035950336 @default.
• W2051259778 cites W2040222253 @default.
• W2051259778 cites W2045418376 @default.
• W2051259778 cites W2045997031 @default.
• W2051259778 cites W2047057727 @default.
• W2051259778 cites W2050259906 @default.
• W2051259778 cites W2050716019 @default.
• W2051259778 cites W2052898293 @default.
• W2051259778 cites W2054950553 @default.
• W2051259778 cites W2059815797 @default.
• W2051259778 cites W2062803021 @default.
• W2051259778 cites W2063820576 @default.
• W2051259778 cites W2071088822 @default.
• W2051259778 cites W2071940267 @default.
• W2051259778 cites W2076411911 @default.
• W2051259778 cites W2077298935 @default.
• W2051259778 cites W2080805884 @default.
• W2051259778 cites W2087048775 @default.
• W2051259778 cites W2088072731 @default.
• W2051259778 cites W2088103235 @default.
• W2051259778 cites W2088421123 @default.
• W2051259778 cites W2089901376 @default.
• W2051259778 cites W2101790876 @default.
• W2051259778 cites W2103946141 @default.
• W2051259778 cites W2111056997 @default.
• W2051259778 cites W2121544019 @default.
• W2051259778 cites W2133851327 @default.
• W2051259778 cites W2142339245 @default.
• W2051259778 cites W2142925815 @default.
• W2051259778 cites W2143465368 @default.
• W2051259778 cites W2151845878 @default.
• W2051259778 cites W2154948430 @default.
• W2051259778 cites W2160088845 @default.
• W2051259778 cites W2252514805 @default.
• W2051259778 cites W4211131955 @default.
• W2051259778 cites W4236042632 @default.
• W2051259778 cites W4244451094 @default.
• W2051259778 cites W4255013341 @default.
• W2051259778 doi "https://doi.org/10.1002/hipo.450020407" @default.
• W2051259778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1308196" @default.
• W2051259778 hasPublicationYear "1992" @default.
• W2051259778 type Work @default.
• W2051259778 sameAs 2051259778 @default.
• W2051259778 citedByCount "55" @default.
• W2051259778 countsByYear W20512597782012 @default.
• W2051259778 countsByYear W20512597782013 @default.
• W2051259778 countsByYear W20512597782014 @default.
• W2051259778 countsByYear W20512597782017 @default.
• W2051259778 countsByYear W20512597782018 @default.
• W2051259778 crossrefType "journal-article" @default.
• W2051259778 hasAuthorship W2051259778A5009643915 @default.
• W2051259778 hasAuthorship W2051259778A5010268706 @default.
• W2051259778 hasAuthorship W2051259778A5015017964 @default.
• W2051259778 hasAuthorship W2051259778A5016032221 @default.
• W2051259778 hasAuthorship W2051259778A5063259248 @default.
• W2051259778 hasConcept C100691959 @default.

• next