Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051260449> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2051260449 endingPage "839" @default.
- W2051260449 startingPage "834" @default.
- W2051260449 abstract "This study used an ex vivo perfusion model to investigate the direct effects of acidosis and alkalosis on the vascular resistance of the canine tibia. Baseline vascular resistance (BVR) and the vascular smooth muscle response to bolus doses of norepinephrine (NE) (0.025–3.2 nmol) and periarterial sympathetic nerve stimulation (NS) (10–25 Hz: 9 V, 2 ms pulses, 10 s) were studied. In Group I, these parameters were measured at normal pH (duration 7.34–7.44) and then during acidosis (pH 7.2–7.33). In Group II, they were measured at normal pH and then during alkalosis (pH 7.47–7.58). In Group III (control), they were measured serially at a normal pH. Alkalosis increased BVR by 56% (p < 0.0001). Acidosis attenuated (18% reduction) and alkalosis enhanced (66% increase) the vasoconstrictor action of NE (p < 0.0001). Acidosis also attenuated (11% reduction) the effect of sympathetic NS (p = 0.012). It is concluded that perfusion pH influences the sensitivity of long bone resistance vessels to circulating NE and sympathetic NS. Thus, local concentration of hydrogen ions may provide bone with a mechanism to autoregulate blood flow." @default.
- W2051260449 created "2016-06-24" @default.
- W2051260449 creator A5007916845 @default.
- W2051260449 creator A5035711526 @default.
- W2051260449 date "1993-11-01" @default.
- W2051260449 modified "2023-09-26" @default.
- W2051260449 title "The effects of acidosis and alkalosis on long bone vascular resistance" @default.
- W2051260449 cites W151037412 @default.
- W2051260449 cites W2006074742 @default.
- W2051260449 cites W2017223059 @default.
- W2051260449 cites W2025510782 @default.
- W2051260449 cites W2025754259 @default.
- W2051260449 cites W2043642699 @default.
- W2051260449 cites W2133924626 @default.
- W2051260449 cites W2291844222 @default.
- W2051260449 cites W2330156218 @default.
- W2051260449 cites W2471999105 @default.
- W2051260449 doi "https://doi.org/10.1002/jor.1100110609" @default.
- W2051260449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8283328" @default.
- W2051260449 hasPublicationYear "1993" @default.
- W2051260449 type Work @default.
- W2051260449 sameAs 2051260449 @default.
- W2051260449 citedByCount "8" @default.
- W2051260449 countsByYear W20512604492013 @default.
- W2051260449 countsByYear W20512604492016 @default.
- W2051260449 crossrefType "journal-article" @default.
- W2051260449 hasAuthorship W2051260449A5007916845 @default.
- W2051260449 hasAuthorship W2051260449A5035711526 @default.
- W2051260449 hasConcept C126322002 @default.
- W2051260449 hasConcept C134018914 @default.
- W2051260449 hasConcept C146957229 @default.
- W2051260449 hasConcept C178853913 @default.
- W2051260449 hasConcept C185592680 @default.
- W2051260449 hasConcept C2777068682 @default.
- W2051260449 hasConcept C2778553927 @default.
- W2051260449 hasConcept C42219234 @default.
- W2051260449 hasConcept C58245268 @default.
- W2051260449 hasConcept C71924100 @default.
- W2051260449 hasConceptScore W2051260449C126322002 @default.
- W2051260449 hasConceptScore W2051260449C134018914 @default.
- W2051260449 hasConceptScore W2051260449C146957229 @default.
- W2051260449 hasConceptScore W2051260449C178853913 @default.
- W2051260449 hasConceptScore W2051260449C185592680 @default.
- W2051260449 hasConceptScore W2051260449C2777068682 @default.
- W2051260449 hasConceptScore W2051260449C2778553927 @default.
- W2051260449 hasConceptScore W2051260449C42219234 @default.
- W2051260449 hasConceptScore W2051260449C58245268 @default.
- W2051260449 hasConceptScore W2051260449C71924100 @default.
- W2051260449 hasIssue "6" @default.
- W2051260449 hasLocation W20512604491 @default.
- W2051260449 hasLocation W20512604492 @default.
- W2051260449 hasOpenAccess W2051260449 @default.
- W2051260449 hasPrimaryLocation W20512604491 @default.
- W2051260449 hasRelatedWork W1966504330 @default.
- W2051260449 hasRelatedWork W1979139803 @default.
- W2051260449 hasRelatedWork W1980147929 @default.
- W2051260449 hasRelatedWork W2026896146 @default.
- W2051260449 hasRelatedWork W2037631372 @default.
- W2051260449 hasRelatedWork W2051260449 @default.
- W2051260449 hasRelatedWork W2088351360 @default.
- W2051260449 hasRelatedWork W2396322301 @default.
- W2051260449 hasRelatedWork W2748952813 @default.
- W2051260449 hasRelatedWork W2899084033 @default.
- W2051260449 hasVolume "11" @default.
- W2051260449 isParatext "false" @default.
- W2051260449 isRetracted "false" @default.
- W2051260449 magId "2051260449" @default.
- W2051260449 workType "article" @default.