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- W2051260687 abstract "The possible mechanisms of the inhibitory effect of ethyl 2-(3-hydroxyanilino)-4-oxo-4,5-dihydrofuran-3-carboxylate (HAJ11) on the respiratory burst of rat neutrophils in vitro was investigated. HAJ11 caused a reversible and a concentration-dependent inhibition of formyl-Met-Leu-Phe (fMLP)-induced superoxide anion (O2−) generation (IC50 4.9±0.7 μm) and O2 consumption (IC50 4.9±1.5 μm). Concanavalin A (Con A)- and NaF-induced O2− generation were also suppressed by HAJ11. However, HAJ11 was a weak inhibitor of the phorbol 12-myristate 13-acetate (PMA)-induced responses. HAJ11 did not scavenge the O2− generation in the xanthine-xanthine oxidase system and dihydroxyfumaric acid (DHF) autoxidation. HAJ11 showed no activity on fMLP-induced inositol phosphates formation and [Ca2+]i elevation in intact neutrophils. In addition, HAJ11 had no effect on neutrophil cytosolic phospholipase C (PLC) activity. HAJ11 reduced fMLP-induced phosphatidic acid (PA) (IC50 29.1±6.5 μm) and phosphatidylethanol (PEt) (IC50 22.6±1.9 μm) formation in a concentration-dependent manner. HAJ11 also reduced protein tyrosine phosphorylation in neutrophils stimulated by fMLP. HAJ11 was a weak inhibitor of neutrophil cytosolic protein kinase C (PKC) activity, and had a negligible effect on brain PKC. Cellular cyclic nucleotides levels were not altered by HAJ11. In addition, HAJ11 did not affect protein kinase A (PKA) activity. HAJ11 had no effect on the O2− generation of PMA-activated and arachidonic acid (AA)-activated NADPH oxidase preparations. Taken together these results indicate that the inhibition of respiratory burst by HAJ11 probably mainly occurs through inhibition of protein tyrosine phosphorylation and phospholipase D (PLD) activity. British Journal of Pharmacology (1997) 120, 79–87; doi:10.1038/sj.bjp.0700861" @default.
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- W2051260687 date "1997-01-01" @default.
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- W2051260687 title "Inhibition by HAJ11 of respiratory burst in neutrophils and the involvement of protein tyrosine phosphorylation and phospholipase D activation" @default.
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- W2051260687 doi "https://doi.org/10.1038/sj.bjp.0700861" @default.
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