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- W2051261268 abstract "In patients with symptomatic severe aortic stenosis (AS), surgical or percutaneous aortic valve replacement (AVR) is the only treatment with proven ability to improve survival [ [1] Otto C.M. Prendergast B. Aortic-valve stenosis—from patients at risk to severe valve obstruction. N. Engl. J. Med. 2014; 371: 744-756 Crossref PubMed Scopus (329) Google Scholar ]. Nonetheless, a consistent proportion of symptomatic patients with severe AS remain un-operated [ [2] Lung B. Cachier A. Baron G. Messika-Zeitoun D. Delahaye F. Tornos P. Gohlke-Bärwolf C. Boersma E. Ravaud P. Vahanian A. Decision-making in elderly patients with severe aortic stenosis: why are so many denied surgery?. Eur. Heart J. 2005; 26: 2714-2720 Crossref PubMed Scopus (916) Google Scholar ]. This patient group has an extremely unfavorable prognosis with no available medical therapy of proven efficacy. Although the majority of these patients are also affected by heart failure, the recommended drugs able to counteract the negative effects of heart failure are generally precluded due to the fear that they could worsen flow obstruction at the valve level. In particular, AS is traditionally considered a contraindication for beta-blockers (BBs) although, in asymptomatic patients with AS, BB use has been associated with improved survival [ [3] Pai R.G. Kapoor N. Bansal R.C. Varadarajan P. Malignant natural history of asymptomatic severe aortic stenosis: benefit of aortic valve replacement. Ann. Thorac. Surg. 2006; 82: 2116-2122 Abstract Full Text Full Text PDF PubMed Scopus (189) Google Scholar ]. We aimed to assess whether BBs could have a protective effect also on patients with symptomatic medically treated AS." @default.
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- W2051261268 date "2015-07-01" @default.
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- W2051261268 title "Beta-blockers can improve survival in medically-treated patients with severe symptomatic aortic stenosis" @default.
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- W2051261268 doi "https://doi.org/10.1016/j.ijcard.2015.04.083" @default.
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