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- W2051265027 endingPage "42" @default.
- W2051265027 startingPage "21" @default.
- W2051265027 abstract "This is an exciting time in the study of Friedreich's ataxia. Over the last 10 years much progress has been made in uncovering the mechanisms, whereby the Frataxin gene is silenced by (GAA)n repeat expansions and several of the findings are now ripe for testing in the clinic. The discovery that the Frataxin gene is heterochromatinised and that this can be antagonised in vivo has led to the tantalizing possibility that the disease might be amenable to a more radical therapeutic approach involving epigenetic modifiers. Here, we set out to review progress in the understanding of the fundamental mechanisms whereby genes are regulated at this level and how these findings have been applied to achieve a deeper understanding of the dysregulation that occurs as the primary genetic lesion in Friedreich's ataxia." @default.
- W2051265027 created "2016-06-24" @default.
- W2051265027 creator A5042273644 @default.
- W2051265027 creator A5072561662 @default.
- W2051265027 creator A5079663586 @default.
- W2051265027 date "2013-07-17" @default.
- W2051265027 modified "2023-09-30" @default.
- W2051265027 title "Gene regulation and epigenetics in Friedreich's ataxia" @default.
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