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- W2051265121 abstract "When rabbits are fed a cholesterol-rich diet they accumulate β-migrating very low density lipoprotein (β-VLDL) in their plasma. β-VLDL are cholesteryl ester-rich lipoproteins which contain apolipoproteins B and E. There are 2 forms of apolipoprotein B in β-VLDL. About 90% of apolipoprotein B is present as a 320 000-dalton protein and the remainder is present as a 210 000-dalton protein. These apolipoproteins are tissue specific. Lipoproteins secreted by perfused rabbit livers contain only the 320 000-dalton apolipoprotein B while lipoproteins secreted by the intestine contain only the 210 000-dalton apolipoprotein B. The tissue specificity of apolipoprotein B shows that β-VLDL is largely of hepatic origin and that only a small fraction is of intestinal origin. The composition of VLDL secreted from the livers of cholesterol-fed rabbits is similar to that of plasma β-VLDL. Both are cholesteryl ester-rich, in contrast to plasma and perfusate VLDL from normal rabbits which are both triglyceride-rich. This indicates that the cholesteryl ester-rich hepatic VLDL is a direct precursor for plasma β-VLDL." @default.
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- W2051265121 title "β-very low density lipoproteins in cholesterol-fed rabbits are of hepatic origin" @default.
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- W2051265121 doi "https://doi.org/10.1016/0021-9150(85)90007-3" @default.
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