Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051265825> ?p ?o ?g. }
- W2051265825 endingPage "214" @default.
- W2051265825 startingPage "204" @default.
- W2051265825 abstract "Abstract Diorganotin(IV) complexes of general formula R 2 SnL (R = Me, 1 ; Bu, 2 ; Ph, 3 ) with tridentate ONO donor Schiff base ligand were synthesized and structurally characterized by adopting various spectroscopic (IR, 1 H 13 C and 119 Sn NMR, UV–Vis, ESI MS, XRD) and analytical techniques. In vitro DNA binding profile of 1 – 3 were carried out by various biophysical methods viz ., UV–Vis titrations, fluorescence, circular dichroic and viscosity measurements which revealed the electrostatic mode of interaction via phosphodiester backbone of DNA duplex. The intrinsic binding constant K b values of L and 1 – 3 were found to be 7.53 × 10 3 , 2.98 × 10 4 , 5.74 × 10 4 and 3.64 × 10 4 M −1 , respectively suggesting the higher binding propensity of 2 , di- n- butyltin(IV) complex as compared to 1 and 3 . Further, the computer-aided molecular docking technique was carried out to validate and rationalize the observed binding affinities towards the molecular target DNA. The resulting binding energies of docked complexes were found to be −212.2, −317.8 and −286.0 KJ mol −1 , respectively. In addition, complex 2 was found remarkably effective against U373MG (CNS), PC3 (prostrate), Hop62 (lung), HL60 (leukemia), HCT15 (colon), SK-OV-3 (ovarian), HeLa (cervix) and MCF7 (breast) cancer cell lines with GI 50 values" @default.
- W2051265825 created "2016-06-24" @default.
- W2051265825 creator A5023643915 @default.
- W2051265825 creator A5084938854 @default.
- W2051265825 date "2014-11-01" @default.
- W2051265825 modified "2023-10-13" @default.
- W2051265825 title "Investigation of diorganotin(IV) complexes: Synthesis, characterization, in vitro DNA binding studies and cytotoxicity assessment of di-n-butyltin(IV) complex" @default.
- W2051265825 cites W1570146341 @default.
- W2051265825 cites W1603870102 @default.
- W2051265825 cites W1969612501 @default.
- W2051265825 cites W1979864066 @default.
- W2051265825 cites W1981338814 @default.
- W2051265825 cites W1981603699 @default.
- W2051265825 cites W2002015225 @default.
- W2051265825 cites W2008075048 @default.
- W2051265825 cites W2009627348 @default.
- W2051265825 cites W2012775604 @default.
- W2051265825 cites W2013694457 @default.
- W2051265825 cites W2021478610 @default.
- W2051265825 cites W2025335219 @default.
- W2051265825 cites W2032555879 @default.
- W2051265825 cites W2034541418 @default.
- W2051265825 cites W2035976921 @default.
- W2051265825 cites W2038124483 @default.
- W2051265825 cites W2039901816 @default.
- W2051265825 cites W2041422388 @default.
- W2051265825 cites W2041869855 @default.
- W2051265825 cites W2042687757 @default.
- W2051265825 cites W2044851985 @default.
- W2051265825 cites W2049286121 @default.
- W2051265825 cites W2049825821 @default.
- W2051265825 cites W2051827258 @default.
- W2051265825 cites W2053861556 @default.
- W2051265825 cites W2090624794 @default.
- W2051265825 cites W2092685945 @default.
- W2051265825 cites W2095344091 @default.
- W2051265825 cites W2095395284 @default.
- W2051265825 cites W2101539565 @default.
- W2051265825 cites W2104033196 @default.
- W2051265825 cites W2106227686 @default.
- W2051265825 cites W2112736429 @default.
- W2051265825 cites W2113161125 @default.
- W2051265825 cites W2130177169 @default.
- W2051265825 cites W2131511717 @default.
- W2051265825 cites W2149000775 @default.
- W2051265825 cites W2159733863 @default.
- W2051265825 cites W2171778773 @default.
- W2051265825 cites W2171917517 @default.
- W2051265825 cites W2324613566 @default.
- W2051265825 cites W2515451511 @default.
- W2051265825 cites W4231374710 @default.
- W2051265825 cites W4375905875 @default.
- W2051265825 cites W1970527663 @default.
- W2051265825 doi "https://doi.org/10.1016/j.ica.2014.07.056" @default.
- W2051265825 hasPublicationYear "2014" @default.
- W2051265825 type Work @default.
- W2051265825 sameAs 2051265825 @default.
- W2051265825 citedByCount "17" @default.
- W2051265825 countsByYear W20512658252015 @default.
- W2051265825 countsByYear W20512658252016 @default.
- W2051265825 countsByYear W20512658252017 @default.
- W2051265825 countsByYear W20512658252018 @default.
- W2051265825 countsByYear W20512658252019 @default.
- W2051265825 countsByYear W20512658252020 @default.
- W2051265825 countsByYear W20512658252021 @default.
- W2051265825 countsByYear W20512658252022 @default.
- W2051265825 countsByYear W20512658252023 @default.
- W2051265825 crossrefType "journal-article" @default.
- W2051265825 hasAuthorship W2051265825A5023643915 @default.
- W2051265825 hasAuthorship W2051265825A5084938854 @default.
- W2051265825 hasConcept C109316439 @default.
- W2051265825 hasConcept C171250308 @default.
- W2051265825 hasConcept C185592680 @default.
- W2051265825 hasConcept C192562407 @default.
- W2051265825 hasConcept C202751555 @default.
- W2051265825 hasConcept C21951064 @default.
- W2051265825 hasConcept C2780841128 @default.
- W2051265825 hasConcept C552990157 @default.
- W2051265825 hasConcept C55493867 @default.
- W2051265825 hasConcept C71240020 @default.
- W2051265825 hasConceptScore W2051265825C109316439 @default.
- W2051265825 hasConceptScore W2051265825C171250308 @default.
- W2051265825 hasConceptScore W2051265825C185592680 @default.
- W2051265825 hasConceptScore W2051265825C192562407 @default.
- W2051265825 hasConceptScore W2051265825C202751555 @default.
- W2051265825 hasConceptScore W2051265825C21951064 @default.
- W2051265825 hasConceptScore W2051265825C2780841128 @default.
- W2051265825 hasConceptScore W2051265825C552990157 @default.
- W2051265825 hasConceptScore W2051265825C55493867 @default.
- W2051265825 hasConceptScore W2051265825C71240020 @default.
- W2051265825 hasLocation W20512658251 @default.
- W2051265825 hasOpenAccess W2051265825 @default.
- W2051265825 hasPrimaryLocation W20512658251 @default.
- W2051265825 hasRelatedWork W2045299745 @default.
- W2051265825 hasRelatedWork W2095277644 @default.
- W2051265825 hasRelatedWork W2366562690 @default.
- W2051265825 hasRelatedWork W2395219877 @default.
- W2051265825 hasRelatedWork W2409963492 @default.