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• W2051266530 abstract "Genetic engineering has developed around technologies enabling the targeted in vitro recombination of DNA molecules found in living organisms. As a result, the development of new DNA molecules has been primarily focused on cloning strategies that allow their assembly from existing DNA fragments. As chemical gene synthesis matures, the design of synthetic DNA molecules becomes the bottleneck of many biotechnology projects. It becomes urgent to develop representations of synthetic genetic systems more abstract than their DNA sequence. Abstraction makes it possible to reuse simple components to build complex systems or to break down a complex engineering problem into manageable tasks. Specialized computer languages or a general purpose XCell Description Language are promising avenues to build abstraction hierarchies for synthetic biology. Genetic engineering has developed around technologies enabling the targeted in vitro recombination of DNA molecules found in living organisms. As a result, the development of new DNA molecules has been primarily focused on cloning strategies that allow their assembly from existing DNA fragments. As chemical gene synthesis matures, the design of synthetic DNA molecules becomes the bottleneck of many biotechnology projects. It becomes urgent to develop representations of synthetic genetic systems more abstract than their DNA sequence. Abstraction makes it possible to reuse simple components to build complex systems or to break down a complex engineering problem into manageable tasks. Specialized computer languages or a general purpose XCell Description Language are promising avenues to build abstraction hierarchies for synthetic biology. a language that is defined by precise mathematical or machine-readable expressions. a computer language for formal description of electronic circuits. It can describe the circuit operation, its design and organization, and tests to verify its operation by means of simulation. elements of a formal grammar that can be transformed by a production rule. They typically correspond to categories of terminal symbols such as ‘verbs’ or ‘nouns’ in natural languages or ‘promoters’ or ‘genes’ in genetic constructs. transformations rules that can be used to derive expressions generated by a formal language. a set of rules that governs the meaning of expressions in a language. An expression semantic value can be used to translate it into another language. symbols that cannot be transformed by any production rule. They correspond to the letters or words of the language. They are the sequences of the genetic elements used to design genetic constructs. refers to an extension of living cells that includes both DNA-based abiotic and biological engineered systems. would be a computer language for formal description of XCells. It would describe their operation, design and organization, and tests to verify its operation by means of simulation. XDL has not been implemented yet." @default.
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• W2051266530 date "2008-10-01" @default.
• W2051266530 modified "2023-09-23" @default.
• W2051266530 title "Genetic design: rising above the sequence" @default.
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• W2051266530 doi "https://doi.org/10.1016/j.tibtech.2008.06.003" @default.
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