FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051266550> ?p ?o ?g. }

• W2051266550 endingPage "129" @default.
• W2051266550 startingPage "123" @default.
• W2051266550 abstract "Oxidative damage is an important factor in prostate carcinogenesis, and overexpression of human MutT homolog (hMTH), a repair gene that removes oxidative damage, is a molecular marker of cellular oxidative stress. Therefore, we tested the hypothesis that overexpression of hMTH in unaffected (normal) surrogate tissue is associated with risk of prostate cancer in a pilot study of 51 patients with diagnosed prostate cancer and 50 age- and ethnicity-matched controls. Total RNA was extracted from phytohemagglutinin-stimulated peripheral blood lymphocytes of these subjects. We performed the real-time reverse transcription-polymerase chain reaction assay to evaluate the relative mRNA expression of three oxidative-damage-repair genes, human MutM homolog (hMMH), hMTH, and human MutY homolog (hMYH), with beta-actin and human O(6)-methylguanine DNA methyltransferase (hMGMT) as the internal controls. The relative gene expression levels of hMMH and hMTH were borderline higher in the cases than in controls (15.3% and 28.8% higher, respectively; P = 0.046 and P = 0.035, respectively), whereas no increase was observed for hMYH and hMGMT. With the median of the controls' values as the cutoff point, we observed that a high expression level of hMTH, but not of other genes, was associated with a significantly increased risk of prostate cancer (odds ratio = 2.62; 95% confidence interval = 1.13-6.75) after adjustment for age and ethnicity. These results suggested that increased expression of hMTH in peripheral lymphocytes may be a risk factor for prostate cancer and support our priori hypothesis. Although our findings were biologically plausible and consistent with the literature, they were preliminary and need to be confirmed in larger studies. In addition, a correlation between the expression level of hMTH and the level of oxidative DNA damage in the target tissues needs to be established as well." @default.
• W2051266550 created "2016-06-24" @default.
• W2051266550 creator A5012002845 @default.
• W2051266550 creator A5013519008 @default.
• W2051266550 creator A5035156015 @default.
• W2051266550 creator A5036947619 @default.
• W2051266550 creator A5060545230 @default.
• W2051266550 creator A5077676007 @default.
• W2051266550 creator A5086525008 @default.
• W2051266550 date "2003-02-27" @default.
• W2051266550 modified "2023-09-26" @default.
• W2051266550 title "Overexpression ofhMTH in peripheral lymphocytes and risk of prostate cancer: a case-control analysis" @default.
• W2051266550 cites W133264087 @default.
• W2051266550 cites W1501603134 @default.
• W2051266550 cites W1558506222 @default.
• W2051266550 cites W1987073910 @default.
• W2051266550 cites W1988716393 @default.
• W2051266550 cites W2003471941 @default.
• W2051266550 cites W2005602594 @default.
• W2051266550 cites W2007755365 @default.
• W2051266550 cites W2011804819 @default.
• W2051266550 cites W2012071848 @default.
• W2051266550 cites W2015179981 @default.
• W2051266550 cites W2017616183 @default.
• W2051266550 cites W2023518603 @default.
• W2051266550 cites W2027632514 @default.
• W2051266550 cites W2033895529 @default.
• W2051266550 cites W2035030519 @default.
• W2051266550 cites W2041017432 @default.
• W2051266550 cites W2059783541 @default.
• W2051266550 cites W2070444732 @default.
• W2051266550 cites W2072028168 @default.
• W2051266550 cites W2076971098 @default.
• W2051266550 cites W2081145376 @default.
• W2051266550 cites W2082385840 @default.
• W2051266550 cites W2083216160 @default.
• W2051266550 cites W2097997344 @default.
• W2051266550 cites W2101324933 @default.
• W2051266550 cites W2109799715 @default.
• W2051266550 cites W2112773853 @default.
• W2051266550 cites W2122174227 @default.
• W2051266550 cites W2336169581 @default.
• W2051266550 doi "https://doi.org/10.1002/mc.10108" @default.
• W2051266550 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12619034" @default.
• W2051266550 hasPublicationYear "2003" @default.
• W2051266550 type Work @default.
• W2051266550 sameAs 2051266550 @default.
• W2051266550 citedByCount "18" @default.
• W2051266550 countsByYear W20512665502013 @default.
• W2051266550 countsByYear W20512665502014 @default.
• W2051266550 countsByYear W20512665502015 @default.
• W2051266550 countsByYear W20512665502017 @default.
• W2051266550 countsByYear W20512665502021 @default.
• W2051266550 crossrefType "journal-article" @default.
• W2051266550 hasAuthorship W2051266550A5012002845 @default.
• W2051266550 hasAuthorship W2051266550A5013519008 @default.
• W2051266550 hasAuthorship W2051266550A5035156015 @default.
• W2051266550 hasAuthorship W2051266550A5036947619 @default.
• W2051266550 hasAuthorship W2051266550A5060545230 @default.
• W2051266550 hasAuthorship W2051266550A5077676007 @default.
• W2051266550 hasAuthorship W2051266550A5086525008 @default.
• W2051266550 hasConcept C104317684 @default.
• W2051266550 hasConcept C121608353 @default.
• W2051266550 hasConcept C126322002 @default.
• W2051266550 hasConcept C134018914 @default.
• W2051266550 hasConcept C150194340 @default.
• W2051266550 hasConcept C153911025 @default.
• W2051266550 hasConcept C156957248 @default.
• W2051266550 hasConcept C2776151105 @default.
• W2051266550 hasConcept C2776235491 @default.
• W2051266550 hasConcept C2780192828 @default.
• W2051266550 hasConcept C502942594 @default.
• W2051266550 hasConcept C54355233 @default.
• W2051266550 hasConcept C555283112 @default.
• W2051266550 hasConcept C71924100 @default.
• W2051266550 hasConcept C86803240 @default.
• W2051266550 hasConceptScore W2051266550C104317684 @default.
• W2051266550 hasConceptScore W2051266550C121608353 @default.
• W2051266550 hasConceptScore W2051266550C126322002 @default.
• W2051266550 hasConceptScore W2051266550C134018914 @default.
• W2051266550 hasConceptScore W2051266550C150194340 @default.
• W2051266550 hasConceptScore W2051266550C153911025 @default.
• W2051266550 hasConceptScore W2051266550C156957248 @default.
• W2051266550 hasConceptScore W2051266550C2776151105 @default.
• W2051266550 hasConceptScore W2051266550C2776235491 @default.
• W2051266550 hasConceptScore W2051266550C2780192828 @default.
• W2051266550 hasConceptScore W2051266550C502942594 @default.
• W2051266550 hasConceptScore W2051266550C54355233 @default.
• W2051266550 hasConceptScore W2051266550C555283112 @default.
• W2051266550 hasConceptScore W2051266550C71924100 @default.
• W2051266550 hasConceptScore W2051266550C86803240 @default.
• W2051266550 hasIssue "3" @default.
• W2051266550 hasLocation W20512665501 @default.
• W2051266550 hasLocation W20512665502 @default.
• W2051266550 hasOpenAccess W2051266550 @default.
• W2051266550 hasPrimaryLocation W20512665501 @default.
• W2051266550 hasRelatedWork W17948615 @default.
• W2051266550 hasRelatedWork W1980245127 @default.

• next